Sentences with phrase «during tumorigenesis»

Although driver mutations were the main focus of cancer research for a long time, passenger mutational signatures, the imprints of DNA damage and DNA repair processes that have been operative during tumorigenesis, are also biologically illuminating.

The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.

Smyd3 function is required for the activation of oncogenic pathways, cell proliferation and epithelial to mesenchymal transition during tumorigenesis.

Deletion of Sox9 prevents skin cancer formation demonstrating the essential role of Sox9 during tumorigenesis and leads to the progressive disappearance of the oncogene expressing cells.

Not exact matches

The absence of tumors in virgin Nrk mutant mice strongly suggests that the tumorigenesis is closely related to the proliferation of mammary epithelial cells during pregnancy.

Putoczki T, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PL, Nguyen P, Preaudet A, Farid R, Edwards K, Boglev Y, Heath JK, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Sieber O, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS and Ernst M. Interleukin - 11 is the dominant IL - 6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.

Using Plk4 overexpression (PLK4OE) during epidermal development, we assess the impact of centrosome amplification and aneuploidy on skin development and tumorigenesis.

The «Meet Our Scientists» video entitled «Our relative the fly» presents the research performed by Marco Millán on the cellular and molecular mechanisms underlying the regulation of tissue growth during normal development, tissue homeostasis, and tumorigenesis.