Sentences with phrase «dynamic nucleosomes»
We believe that the presence of dynamic nucleosomes at highly expressed genes helps to unwind this spring rapidly and as often as necessary,» comments David Shore.
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They speculate that the dynamic nature of the «fragile» nucleosome plays an important role in increasing access of the proteins initiating the transcription to the promoter.
One type, characterized by the presence of dynamic, unstable, nucleosomes, is found at highly expressed genes, such as those involved in the control of cell growth and division.
Because this region covers the entire CenHs - binding region (around 750 kb), the authors [6] postulated that CenH3 - containing and dimethyl - K9 H3 - containing nucleosomes are interspersed and that the position of these nucleosomes is dynamic, so that a population of cells may have the same DNA sequence interacting with both types of nucleosome.
Li M, Hada A, Sen P, Olufemi L, Hall MA, Smith BY, Forth S, McKnight JN, Patel A, Bowman GD, Bartholomew B, Wang MD. (2015) Dynamic regulation of transcription factors by nucleosome remodeling.
Nucleosome remodelers can work if tethered (33), but given the dynamic nature of DNA interactions observed with most transcription factors, we think that the tethering rather increased the local concentration of the factor around the UASGal site.