Sentences with phrase «dynamic regulation»
Methylation of mammalian DNA and histone residues are known to regulate transcription, and the discovery of demethylases that remove methylation in DNA and histones provide a basis for the understanding of dynamic regulation of mammalian gene expression.
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The laboratory currently pursues four integrated research objectives: 1) Defining how dynamic regulation of adhesion and migration controls metastasis, 2) Identification and characterization of the metastatic cell populations within a primary tumor, 3) Experimental modeling of metastasis in a clinically relevant manner, and 4) clinical implementation of molecular markers of migration as biomarkers of tumor progression and metastasis.
All of these functions require dynamic regulation of microtubule lengths.
Proteomic analysis of arginine methylation sites in human cells reveals dynamic regulation during transcriptional arrest.
Many of the encoded transporters, including those for glutamate, are subject to sophisticated dynamic regulation, and are also ion channels in addition to being transporters.
«Our findings explain the underlying mechanisms behind the dynamic regulation of the identity of interneurons», said Nathalie Dehorter of the MRC CDN and first author of the study.
Understanding how a dynamic regulation of cellular energy contributes to the development of neuronal circuits.
Li M, Hada A, Sen P, Olufemi L, Hall MA, Smith BY, Forth S, McKnight JN, Patel A, Bowman GD, Bartholomew B, Wang MD. (2015) Dynamic regulation of transcription factors by nucleosome remodeling.
This dynamic regulation implies that escape from the primary tumor from is very much a non-linear aspect of metastasis that is less influenced by cancer genetics and more by the cellular context, interactions with adjacent tumor cells, the host and response to changing microenvironments.
These studies will lead to in - depth investigations of tumor heterogeneity and the dynamic regulation of genes that define subpopulations with specialized biologic functions.