A high throughput in vivo protein - DNA mapping approach reveals principles
of dynamic gene regulation in mammals / M. Garber *, N. Yosef *, A. Goren, R. Raychowdhury, A. Thielke, M. Guttman, J. Robinson, B. Minie, N. Chevrier, Z. Itzhaki, A. Weiner, D. Friedrich, J. Meldrim, O. Ram, C. Chang, A. Gnirke, S. Fisher, N. Friedman, B. Wong, B. Bernstein, C. Nusbaum, N. Hacohen, A. Regev, I. Amit.
The Sarma laboratory is interested in the mechanisms
of epigenetic
gene regulation, or how the
dynamic modifications
of the architecture
of chromatin, the complex
of DNA and proteins within the nucleus
of our cells, impacts
gene expression and cellular function.
Methylation
of mammalian DNA and histone residues are known to regulate transcription, and the discovery
of demethylases that remove methylation in DNA and histones provide a basis for the understanding
of dynamic regulation of mammalian
gene expression.