Sentences with word «dynamin»

Five - Link front suspension, double upper and lower wishbone, anti-roll bar, air suspension / supension with dynamin Ride Control

Saipraveen Srinivasan, Christoph Burckhardt, Sandra Schmid and co-workers use live cell imaging reveals a non-canonical and isoform - specific role for dynamin - 1, the fission GTPase, in regulating the assembly and maturation of clathrin - coated pits, and functioning as a nexus between signaling and endocytosis.

Guanosine triphosphate hydrolysis limits polymerization of the membrane protein dynamin on lipid nanotubes into short, metastable collars.

Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling

Using lipid nanotubes as substrates to directly measure geometric intermediates of the fission pathway, we found that GTP hydrolysis limits dynamin polymerization into short, metastable collars that are optimal for fission.

A variety of models have been suggested to explain how dynamin works.

The research team found that when a particular mitochondrial fission protein (GTPase dynamin - related protein - 1 — Drp1) was blocked using either gene - therapy or a chemical approach in experimental models of PD in mice, it reduced both cell death and the deficits in dopamine release — effectively reversing the PD process.

The guanosine triphosphatase (GTPase) dynamin builds up membrane stress by polymerizing into a helical collar that constricts the neck of budding vesicles.

People in Aussies sometimes associate the disease with Exercise Induced Collapse (EIC), more properly called dynamin - associated EIC, in the Labrador and other Retrievers.

The transition to compartmentalization and a eukaryotic cellular organization was facilitated by: (i) the ability to lipidate GTPases; (ii) the coupling of SNARE and longin domains; and (iii) the acquisition of dynamins and CopII - like coatamer proteins.

Dynamin is the prototypical member of a large family of structurally related guanosine triphosphatases involved in membrane fission and fusion.

This local coordination of dynamin and lipids suggests how membranes can be remodeled in cells.

Collars as short as two rungs translated radial constriction to reversible hemifission via membrane wedging of the pleckstrin homology domains (PHDs) of dynamin.

Shnyrova et al. (p. 1433; see the Perspective by Holz) reconstituted dynamin - mediated membrane scission on lipid nanotubes and suggest a molecular model for dynamin activity that takes into consideration all known aspects of dynamin function.

Dynamins are functionally associated with synapses, which are important for the communication between nerve cells.

Dynamin - Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy.

The dynamin - related GTPase Drp1 is required for embryonic and brain development in mice.

At costameres, CHC is co-expressed with dynamin 2 (DNM2), another key protein of the intracellular membrane trafficking machinery which is mutated in autosomal dominant centronuclear myopathy (CNM).

Depletion of dynamin - binding protein or Tuba, a guanine nucleotide exchange factor, disrupted renal ciliogenesis in cell culture and led to abnormal kidney morphology in a Tuba knockdown zebrafish model of PKD.

Knockdown of dynamin - binding protein or Tuba results in abnormal kidney development and other aberrant phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).

Genetic testing excluded the dynamin - 1 related exercise - induced collapse mutation and the V547A malignant hyperthermia mutation as the cause of BCC.

Normal and BCC affected dogs are negative for the dynamin 1 mutation causing EIC in Labrador Retrievers.

Dogs with BCC do not have the dynamin 1 (DMN1) mutation that causes EIC in Labrador Retrievers and other breeds for which there is a DNA test.

A study published in 2008 in the journal Nature Genetics revealed the wobbly legs are linked to the dynamin 1 gene.

The study researchers found some 30 percent of Labrador retrievers carry the mutant gene though they may not show symptoms since they don't carry two copies of the dynamin 1 variant.