Sentences with phrase «dynein molecules»
Dr Burgess said: «During brain development, neurons must crawl into their correct position and dynein molecules in this instance grab hold of the nucleus and pull it along with the moving mass of the cell.
https://www.sciencedaily.com/
At the molecular level, individual dynein molecules whose shapes are stabilized by prestress were found to have areas of increased rigidity around their ATP binding sites, which resist deformation by incoming energy from ATP and instead translate that force into the dynein molecule's characteristic movement.
However, when they then «fixed» a specific hinge region of the dynein molecule that is known to connect dynein to its microtubule, they discovered that the dynein to spontaneously moved in its characteristic direction when force was applied at the ATP binding site, matching the way it moves in nature.
Not exact matches
Dynein switches between these different conformations as a result of the conversion of a molecule of ATP to ADP at a specific binding site on the protein, which releases energy as a chemical bond is broken.
They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.
«Additionally, while previous studies of dynein have revealed the molecule's two different static conformations, our animation visually depicts one plausible way that the protein can transition between those shapes at atomic resolution, which is something that other simulations can't do.
The team found changes in a gene encoding a previously unknown «dynein,» a protein that moves like a railroad locomotive along cytoskeletal fibers called microtubules, hauling other molecules as cargo.
His research focuses on the development of high - precision, single - molecule methods to study the mechanism of action of macromolecular machines, such as dynein, telomerase, and Cas9.
«Previously, dynein movement had only been tracked by attaching fluorescent molecules to the proteins and observing the fluorescence using very powerful light microscopes.