Sentences with phrase «dysfunctional mitochondria which»

This stress is just powerful enough to kill off old and dysfunctional mitochondria which stimulates the growth of new and more powerful mitochondria (5).

Not exact matches

«They end up with many dysfunctional mitochondria, which compromise repair of injured myofibers.

The Leuven - based VIB researchers Dominik Haddad, Vanessa Morais and Patrik Verstreken have unraveled the mechanism by which brain cells trigger the destruction of dysfunctional mitochondria.

Moreover, dysfunctional mitochondria are not efficiently discarded from the cell, which complicates the operation of other healthy mitochondria and leads to insufficient energy production in the cell.

All of this damage damages extremely precious mitochondrial DNA, which make the mitochondrias dysfunctional, clogging lysosome for mitophagy, and being incapable of keeping mitochondrial membrane potential (leading to Cytochrome C loss through mitochondrial permeability pores) and mitochondrial ATP OXPHOS respiration.

Now, scientists at the Salk Institute have uncovered an unexpected way in which cells trigger this critical response to threats, offering insight into disorders such as mitochondrial disease, cancer, diabetes and neurodegenerative disease — particularly Parkinson's disease, which is linked to dysfunctional mitochondria.

At the same time, autophagy helps to remove dysfunctional mitochondria, which would otherwise produce harmful reactive oxygen species.