Sentences with phrase «dysfunctional proteins»

A genetic cure for the disease would require completely replacing the mutated gene because any remaining dysfunctional protein would continue to form damaging aggregates.

Unfoldases are able to recognize, unfold, and address misfolded or dysfunctional proteins towards proteolytic complexes.

If a piece of mRNA is found to be defective, it is destroyed so that it can not go on to produce dysfunctional proteins that can harm the cell.

It generates misfolded, dysfunctional proteins which can lead to all sorts of degenerative diseases down the road.

Autophagy is the process by which cells capture large dysfunctional proteins, aging cell components, and invading pathogens into packages to be disposed of (7).

More than half have a form of the disease called EB simplex, which is caused not by a missing protein, but by mutations that produce an active but dysfunctional protein.

Since the dysfunctional protein, IkBe, normally functions as an inhibitor, the mutation leads to activated signalling compared to the normal situation», says SciLifeLab faculty member Richard Rosenquist who led the study.

This involves the cells breaking down and metabolizing broken and dysfunctional proteins that build up inside cells over time.