Not exact matches
«We have seen SF3B1 mutation in chronic lymphocytic leukemia and in myeloid
dysplastic disorders, and now we show its importance in mucosal melanoma,» says Aik Choon Tan, PhD, investigator
at the CU Cancer Center and associate professor of Bioinformatics
at the CU School of Medicine.
Although people with
dysplastic moles are
at higher risk of developing melanoma, most
dysplastic moles do not turn into melanoma.
However, affected puppies are born with normal hips — the
dysplastic changes are not there
at birth.
If you look
at the hip dysplasia statistics of the Orthopedic Foundation of America, hip X-rays of 4000 Flat - Coats were evaluated and only 4 % were
dysplastic, which would be a good rate for this size dog — except that the true rate is higher because most of the obviously bad X-rays were not sent in for official evaluation.
Elbow X-rays: Recently, the dog community has become aware that elbows are also
at risk of becoming
dysplastic.
There are many
dysplastic dogs out there that had vets look
at their x-rays and pronounce them «wonderful.»
Dr. Donald Patterson, chairman of Medical Genetics
at University of PA School of Veterinary Medicine, states that some dogs with radiographically normal hips but a large number of hidden dysplasia - producing genes, if mated together, will produce
at least some
dysplastic offspring.
There are many
dysplastic dogs out there that had vets look
at their X-rays and pronounce them «wonderful.»
Elbow dysplasia is just behind
at with 40 % of
dysplastic Bulldogs.
They call our attention to the fact that there are many dogs (usually of certain breeds) that do not develop DJD but are OFA - assessed as
dysplastic because of laxity
at two years» age.
For example, while it is possible for any Golden with normal hips to produce
dysplastic offspring, a Golden Retriever with normal hips from a litter where the majority of its siblings have hip dysplasia may be
at particularly high risk to produce
dysplastic offspring.
Even more importantly, there is the greater number that were adjudged «normal»
at two years but later developed DJD or, if not re-radiographed, produced an unacceptably high percentage of
dysplastic descendants.
The 40 dogs described as «normal»
at 2 years of age all had some «minimal or mild degenerative changes» by 9 years of age, and those 22 dogs diagnosed as
dysplastic (lax joints in the hip - extended view)
at 2 years had the same mild or minimal changes.
Conversely, if a dog with tight sockets is radiographed without rotating the femurs sufficiently, the femoral neck may appear shortened and
at a valgus angle, both of which may cause some less - experienced vets to give a
dysplastic diagnosis to a «normal» set of hips.
Dr. Lennart Swenson, geneticist
at the Swedish University of Agricultural Sciences, calls our attention to the fact that it is relatively easy to define «normal» and segregate them from «affected» (
dysplastic elbows), and select our breeding stock from the former class.