Sentences with phrase «dysregulation associated»

Mitigating HPA axis dysregulation associated with placement changes in foster care.

In high - risk adolescents, this normative shift may tip the balance toward stress response dysregulation associated with depression and other psychopathology.

Exacerbating the mineral dysregulation associated with these many conditions are the neurotransmitter imbalances provoked by mercury.

Not exact matches

«Before our work in rhesus monkeys, it has not been possible to detect or observe some of these symptoms in other HD animal models, especially emotional dysregulation,» says senior author Chan, associate professor of human genetics at Yerkes National Primate Research Center and Emory University School of Medicine.

Interestingly, IBS biologists uncovered additional miRNA end modifications after DROSHA processing, which are expected to be important for the regulation of miRNA biogenesis, whose dysregulation is often associated with diseases, in particular with cancer.

Our tentative, though testable, findings may provide a direction for the development of personalized treatments for a patient subgroup whose illness is associated with a dysregulation of brain glutamate function.»

«We know dysregulation of a protein enzyme called multifunctional CaM kinase II plays a role in disrupting sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

Dysregulation of DDR and repair is closely associated with human diseases such as cancers, cardiovascular disease, neurodegenerative disorders and aging.

Recent studies have shown GSK3 dysregulation to be associated with a number of diseases, including Type II diabetes, Alzheimer's disease, inflammation, cancer, and bipolar disorder (D Wu and W Pan.

These results are consistent with the observed deactivation of the immune system (Supplementary Fig. 21b), since similar trends are observed to be associated with dysregulation of the immune system with age.

In recent years, the etiology of psychiatric disorders has been increasingly associated with epigenetic dysregulation, especially the effects of DNA methylation.

Additionally, circadian misalignment is associated with alterations in cortisol and leptin secretion in relation to wake - sleep and feeding - fasting cycles causing further aggravating dysregulation of glucose and energy homeostasis (258, 259).

IL - 17 is produced mainly by pathogenic ILC3s associated with chronic inflammation and cytokine dysregulation [11] and we did not readily detect IL - 17 in our studies.

Using a nonhuman primate model, their findings provide insight into the mechanisms of human psychiatric disorders associated with emotion dysregulation, such as PTSD (post-traumatic stress disorder) and schizophrenia.

The results of the mouse models suggest that APC dysregulation is associated with initiation and progression of at least some breast cancers.

Wu says his lab will investigate the role that localized protein synthesis plays in the growth and connection of neurons — work that ultimately could lead to new interventions for conditions such as autism and Alzheimer's disease, which are associated with a dysregulation of localized protein production.

Cortisol dysregulation has long been associated with lower levels of collagen, which your body needs to maintain skin thickness.

These include insoluble extracellular plaques made of beta - amyloid peptide (Aβ); intracellular neurofibrillary tangles (NFTs) resulting from the hyperphosphorylation of tau (a microtubule - associated protein); loss of hippocampal neurons; a decrease in production of brain acetylcholine; and a marked decline in glucose usage in regions of the brain associated with memory and learning.5,11,20 - 22 All of these changes can be logically explained as the sequelae resulting from long - term dysregulation of insulin signaling and glucose metabolism.

In addition to reviewing the evidence associating POPs to these conditions, this article explores the possible contribution of farmed Atlantic salmon — a significant and common dietary source of POPs — with blood sugar dysregulation conditions.»

They also may inhibit leptin, a hormone made by adipose cells which inhibits hunger and this dysregulation may be one of the ways that feeding infant formula encourages obesity and weight gain in infants and later in life.59 • Protease inhibitors are substances that inactivate some key digestive enzymes like trypsin and chymotrypsin and are associated with pancreatitis and pancreatic enlargement.

Low hair cortisol has been associated with depression, generalized anxiety disorder and adrenal dysregulation.

And in an ad lib setting, «Laboratory studies in healthy young volunteers have shown that experimental sleep restriction is associated with a dysregulation of the neuroendocrine control of appetite consistent with increased hunger and with alterations in parameters of glucose tolerance suggestive of an increased risk of diabetes» (Van Cauter et al., 2007).

· Cancer Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast (CAF);

There are many possible underlying causes and conditions associated with POTS including HPA axis dysregulation, autoimmune disorders, viruses, and reactive hypoglycemia.

``... several animal studies indicate serious health risks associated with GM food consumption including infertility, immune dysregulation, accelerated aging, dysregulation of genes associated with cholesterol synthesis, insulin regulation, cell signaling, and protein formation, and changes in the liver, kidney, spleen and gastrointestinal system.»

As far as depression is concerned, it is well - established that depression is associated both with stress and MS via neurohormonal (e.g., dysregulation of the HPA axis), physical (e.g., fatigue) and psychosocial factors (fear and / or frustration deriving from the progressive nature and the unpredictable course of this disease, quality of life, etc.)(Heesen et al., 2003).

Children who do not complete high school, for example, are more likely to become teenage parents, to be unemployed, and to be incarcerated, all of which exact heavy social and economic costs.5 A growing body of research shows that child poverty is associated with neuroendocrine dysregulation that may alter brain function and may contribute to the development of chronic cardiovascular, immune, and psychiatric disorders.6 The economic cost of child poverty to society can be estimated by anticipating future lost productivity and increased social expenditure.

Third, chronic stress associated with family violence may alter hypothalamic - pituitary axis functioning, lead to dysregulation of neuroendocrine systems controlling appetite, and influence hormonal regulation of visceral fat distribution.35 Other traumatic childhood experiences have been linked to altered serotonin and cortisol systems.70 Overlapping research has shown that bulimia is associated with decreased serotonin metabolites in cerebrospinal fluid,71 - 73 reduced platelet binding of serotonin reuptake inhibitors, 73 reduced density of paroxetine - binding sites, and altered cortisol function.70 Thus, early - life disruption of neuroendocrine systems may elevate risk for disordered eating behaviors and suboptimal fat storage and distribution.

In fact, the person you care about may have traits associated with borderline personality disorder (BPD), such as emotion dysregulation, impulsive behavior, unstable sense of self, and difficulty with interpersonal relationships.

The present study was driven by recent findings about the relationship between beliefs about emotions, behaviours associated with emotion dysregulation, and specific ER processes (Tamir et al., 2007; Manser et al., 2012; De Castella et al., 2013).

Limbic dysregulation is associated with lowered heart rate variability and increased trait anxiety in healthy adults.

At baseline, behavioral signs of stress reactivity in children's peer entry behavior were significantly associated with parent ratings of child internalizing behavior (r = 0.37, P <.001), child dysregulation (r = 0.30, P =.004), and 2 different indices of disruptive behavior during parent - child play interactions (r = 0.45, P <.001; r = 0.35, P =.008).40 The peer entry procedure appears to be stressful in general and to elicit more signs of stress in children with mental health problems.

The prenatal phase of the program reduced fetal exposure to tobacco, improved the qualities of women's prenatal diets, reduced rates of pyelonephritis, improved levels of informal social support, and reduced intellectual impairment and irritable behavioral styles associated with fetal exposure to tobacco.6, 10,11,22 Prenatal exposure to tobacco is a risk factor for early behavioral dysregulation, problems with attention, and later crime and delinquency.22 Moreover, the combination of birth complications (and, by implication, neurological impairment) and rejecting parenting substantially increases the likelihood of violent offenses by the time children are 18 years old.5

This workshop will explore the influence of procedural learning on adult relationships, the impact of trauma and attachment failure on adult attachment behavior, and explore techniques that range from helping patients stabilize dysregulation to exploring the intense emotions associated with early attachment relationships.

The past 20 years has seen a steady increase in the estimated prevalence of autism spectrum disorder (ASD) in childhood and a recent UK estimate is 1.7 % with many preschool children receiving early diagnoses.1 Children with ASD often have associated difficulties including hyperactivity, anxiety, hypersensitivity to sounds and materials, sleeping difficulties, and emotional dysregulation.2 These behavioural problems present challenges for parents.

Core emotional traits and interpersonal behaviors may be associated with cognitive dysregulation, i.e., cognitive functions may become impaired at times of interpersonal stress leading to information processing in a concrete, black - and white, all - or - nothing manner.

Accordingly, prospective longitudinal studies in Developmental Traumatology are critical to the effort to develop early interventions to attenuate the psychobiological dysregulation and adverse effects on brain development associated with maltreatment.

Whether mothers with higher levels of depressive symptoms are aware or not, the behaviors associated with depression such as low frequency of talk, emotional dysregulation, and elevated levels of controlling and self - centered messages appear to communicate emotional distance and unavailability to their offspring.

The findings indicated that parental emotion dysregulation was associated with their supportive reactions to children's negative emotions and these reactions interacted with the co-caregiver's emotion dysregulation to exert an effect on children's emotion regulation.

Limited research has investigated how the characteristics of parents, such as parental emotion dysregulation, are associated with their reactions to children's emotions.

We speculate that next to genetic transmission problematic parent - child interactions and heightened family stress associated with parental psychopathology could result in general dysregulation and related psychophysiological response patterns in children [82].

CU traits showed the second strongest unique associations with overt aggression, delinquency and behavioral dysregulation, but were not associated with relational aggression or emotional dysregulation.

Lastly, Machiavellian traits showed a strong unique association with emotional dysregulation, but were not uniquely associated with externalizing behavior problems.

For instance, emotion dysregulation may be more strongly associated with internalizing problems for females, and more strongly with aggressive behavior for males.

Further, we hypothesized that cognitive emotion dysregulation and impulsivity would be associated with current and lifetime suicidal ideation.

Using structural equation modeling, emotion - related variables were identified that were common to both anxiety and depression (poor emotion awareness, emotion dysregulation, poor emotion regulation coping, high frequency of negative affect), most strongly related to depression (low frequency of positive affect), and most distinctly associated with anxiety (frequency of emotion experience, somatic response to emotion activation).

Poor prenatal and early postnatal nutrition is not only associated with lower cognitive function (Barker et al. 2013), but also with higher conduct problems, emotional dysregulation, and hyperactivity (Liu and Raine 2011; Jacka et al. 2013).

Maternal interpersonal sensitivity was positively associated with child social problems, and this relationship was fully mediated by child emotion dysregulation.

Emotion dysregulation has been associated with increases in many forms of psychopathology in adolescents and adults.