Sentences with phrase «dysregulations of»

We specified the model on the basis of theoretical concerns, as SCL contains four items (items 1, 2, 3, and 5) pertaining to the presence of dysregulations of biological functions (sleeping and eating), whereas the remaining five items (items 6 — 10) refer to problematic externalizing behaviors.

Harkness has characterized it as trying «to push stimulation to the maximum without going over the edge into dysregulation of basic state control.»

Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behavior.

This heightened sensitivity to light may make them even more susceptible to dysregulation of sleep and the circadian clock.»

Therefore, it is essential that we learn how specific types of chemical modifications normally regulate RNA function in our cells, in order to understand how dysregulation of this process contributes to human disease, says Cristian Bellodi.

Initial immunological investigations suggested a genetically determined dysregulation of the immune system.

«An opioid addiction has a dysregulation of brain functions, decision making abilities, your ability to control your impulses, dampens your response to your natural pleasures, impacts learning and memory.»

The study found dysregulation of these hormones in people who had been abused or neglected as children.

The international research team behind the study now suggests that targeting inflammation and fibrosis in the small blood vessels of the pancreatic islets may offer a new way of treatment for age - dependent dysregulation of blood glucose levels.

«Like in all immune modulatory therapies,» Feske adds, «the benefits of incomplete calcium channel inhibition need to be balanced against the dysregulation of the immune response that results when these channels are blocked completely,»

Our tentative, though testable, findings may provide a direction for the development of personalized treatments for a patient subgroup whose illness is associated with a dysregulation of brain glutamate function.»

Circadian misalignment can lead to dysregulation of energy metabolism according to previous studies.

This finding suggests males may be more susceptible than females to dysregulation of multiple genes under conditions of RORA deficiency.

«We know dysregulation of a protein enzyme called multifunctional CaM kinase II plays a role in disrupting sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.

I explained to Eric that we believe that OCD involves a dysregulation of the neurotransmitter serotonin and that sertraline increases serotonin in brain cell synapses, relieving the symptoms.

The investigators speculate that the otopetrins maintain the pH appropriate for formation of otoconia and that the defect in the tlt mice is due to a dysregulation of pH.

In Nrk mutant mice, therefore, mammary tumorigenesis was proposed to be triggered by a combination of dysregulation of proliferation in mammary epithelial cells and excessive blood estrogen.

«We were able to use a set of cutting - edge tools to gain insight into a critical cellular process for normal brain development, the dysregulation of which may be a manifestation of a genetic predisposition for schizophrenia,» says senior author Dr. Guo - li Ming, of Johns Hopkins University School of Medicine.

In the first magnetic resonance imaging (MRI) report of early brain overgrowth in autism a decade ago, it was theorized that excess numbers of neurons could be an underlying cause, perhaps due to prenatal dysregulation of proliferation, apoptosis, or both.1

«This capability will be critical for studying the molecular basis of disease, for example, how dysregulation of protein synthesis in brain cells can lead to the memory deficits that occur in neurodegeneration.»

Our work aims to investigate mechanistically the molecular processes through which dysregulation of factors controlling oxidative stress impairs RPE and photoreceptor cell metabolism and their survival in AMD.

HTLV - 2 Tax immortalizes human CD4 + memory T lymphocytes by oncogenic activation and dysregulation of autophagy.

This work aims to investigate, mechanistically, the molecular processes related to dysregulation of factors that normally protect the eye against oxidative stress, thus impairing RPE and photoreceptor cellular metabolism and their survival in AMD.

Unbiased metabolite profiling of schizophrenia fibroblasts under stressful perturbations reveals dysregulation of plasmalogens and phosphatidylcholines Huang JH, Park H, Iaconelli J, Berkovitch SS, Watmuff B, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R. Journal of Proteome Research.

HTLV - 2 Tax immortalizes human CD4 + memory T lymphocytes by oncogenic activation and dysregulation of autophagy % U http://www.jbc.org/content/early/2012/08/13/jbc.M112.377143.short.

Dysregulation of DDR and repair is closely associated with human diseases such as cancers, cardiovascular disease, neurodegenerative disorders and aging.

N - glycosylation is important for efficient trafficking of GLUT4 to its proper compartments in adipocytes (51), suggesting one mechanism by which dysregulation of these genes could contribute to T2D.

These results are consistent with the observed deactivation of the immune system (Supplementary Fig. 21b), since similar trends are observed to be associated with dysregulation of the immune system with age.

The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia

This novel approach, which reveals complex interactions between cells and proteins, can also be used for other diseases to generate new knowledge about the regulation and dysregulation of the immune system, which can eventually give rise to new, improved immunological therapies.

Dysregulation of adiponectin action is relevant in the development of T2DM (44).

Title: The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia Author: D. Martins - de-Souza et al..

Environmental exposure to heavy metals and dysregulation of iron, copper and other metal homeostasis may contribute to pathomechanisms of neurodegeneration.

These findings lead to the hypothesis that impaired immune responses in the elderly to infection or vaccination reflects dysregulation of immunoregulatory pathways and metabolic pathways, which work in concert to orchestrate an effective immune response in young healthy individuals.

Additionally, circadian misalignment is associated with alterations in cortisol and leptin secretion in relation to wake - sleep and feeding - fasting cycles causing further aggravating dysregulation of glucose and energy homeostasis (258, 259).

They hypothesize that specific genes in the Williams syndrome region may be involved in the dysregulation of specific neuropeptide and hormonal systems, which could explain the observed hypersocial behavior.

Characterized as a biological subset of PTCL - NOS, patients with dysregulation of the histone modification machinery may be amenable to therapeutic intervention with HDAC inhibitors, given either alone or in combination with hypomethylating agents.

Dysregulation of cytokine signalling is understood to induce autoimmunity.

We postulate that the kidney phenotype in BicC1 mutant mice is caused by dysregulation of a microRNA - based translational control mechanism.

The most common mechanism for constitutive activation and phosphorylation of STAT factors is the dysregulation of tyrosine kinases.

Beckelman BC, Day S, Zhou X, Donohue M, Gouras GK, Klann E, Keene CD, Ma T. (2016) Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.

Chronic stress leads to a dysregulation of the hypothalamic - pituitary - adrenal (HPA) axis which can constitute a base for pathophysiological consequences.

91/2: 30 Epigenetic and transcriptional dysregulation of oxytocin receptor (Oxtr) in Tet1 methylcytosine dioxygenase deficient mouse brain.

Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant - negative isoform, and loss of expression of the potential tumour suppressor p51.

This study shows for the first time proteins interacting with Nbeal2 and points to the dysregulation of the canonical signaling pathway of Dock7 as a possible cause of the aberrant formation of platelets in GPS cases and Nbeal2 deficient mice.

We also propose that the dysregulation of the balance between sphingolipids and glycerophospholipids results in a lipotoxic insult relevant in the pathophysiology of common metabolic diseases, typically characterised by their increased ceramide / sphingosine pools.

Wu says his lab will investigate the role that localized protein synthesis plays in the growth and connection of neurons — work that ultimately could lead to new interventions for conditions such as autism and Alzheimer's disease, which are associated with a dysregulation of localized protein production.

For people with dysregulation of the control system for CRH and cortisol, the hypothalamic - pituitary - adrenal axis, you may need to back off your workouts in order to fully heal, as part of a comprehensive functional medicine protocol.

Emerging research shows that each of these ailments may be related to dysregulation of the endocannabinoid system, or ECS for short.

hot flashes, which are a sign of inflammation of a sort of our central nervous system — a dysregulation of the temperature regulation center of the brain.