Sentences with phrase «dystrophic rcs»
No head - tracking response is observed in the 16 - week old dystrophic RCS rat during optokinetic testing of the right, non-transplanted, eye.
http://journals.plos.org/
A head - tracking response is observed in the dystrophic RCS rat during optokinetic testing of the left eye, 13 weeks after iPS - RPE cell transplantation.
(A) Extensive preservation of the nuclear photoreceptor layers in the dorsal retina of the dystrophic RCS rat 13 weeks following transplantation of iPS - RPE cells (DAPI stained nuclei).
iPS - RPE cells were transplanted into dystrophic RCS rat eyes at three weeks of age, a time when retinal abnormalities are first observed.
iPS - RPE cells were injected into the subretinal space between the host RPE and photoreceptor cells (B) A layer of iPS - RPE cells in the subretinal space of the dystrophic RCS rat 20 hours following transplantation.
In dystrophic RCS rats, threshold levels at P100 are greater than 3.0 log units above the background level of 0.02 log candela / m2.
Not exact matches
We used the head - tracking response to assess the visual function of RCS dystrophic rats 13 weeks after receiving a subretinal iPS - RPE transplantation in one eye only (Fig. 6 and Movies S2 and S3).
In order to test the therapeutic efficacy of iPS - RPE, we transplanted cells into the subretinal space of RCS dystrophic rats (Fig. 5A).
(A) Preservation of optokinetic head - tracking response to a rotating vertical stimulus in 16 - week - old RCS dystrophic rats following transplantation of iPS - RPE.
The progression of retinal dystrophy in the RCS rat is such that by 13 weeks post-graft most of the ONL has disappeared [33] and the photoreceptor outer segment layer is reduced to a debris zone [40], a finding we observed in dystrophic controls.
iPS - RPE are capable of phagocytosing photoreceptor material, in vitro and in vivo following transplantation into the Royal College of Surgeons (RCS) dystrophic rat.
Inset shows higher resolution confocal images of photoreceptor cell nuclear layers (DAPI blue) and rhodopsin expression (red) in the dystrophic control (left inset) and dystrophic with iPS - RPE transplant (right inset) RCS rat.