Darabi R, Arpke RW, Irion S, et al., Human ES - and iPS - derived myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in
dystrophic mice.
Working in
dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's laboratory team first identified a unique population of muscle - derived stem cells with the ability to repair muscle 8 years ago.
Reyes lab began by treating old
dystrophic mice with direct injection of THI.
Later, the researchers simply added the compound to the drinking water in the habitats of young
dystrophic mice.
In vivo gene editing in
dystrophic mouse muscle and muscle stem cells.