Sentences with phrase «dystrophic muscle»
The technique partially restored not only functional dystrophin expression, but also dystrophic muscle function.
https://www.jax.org/
Topics such as the mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age - related atrophy are examined using a large variety of cellular, molecular and whole - animal in vivo assays of function.
«VBP15 has an additional property of addressing membrane defects in dystrophic muscle cells,» remarked Kanneboyina Nagaraju, DVM, PhD, the lead author of the study, and principal investigator in the Center for Genetic Medicine at Children's National.
The study «Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation» is published in the journal Scientific Reports.
This approach has proved successful in disrupting multiple genes simultaneously in neurons and in editing the Dmdmdx mutation in muscle, thereby restoring dystrophin protein expression and partially alleviating the dystrophic muscles» functional deficiencies.
Read the full article, «Branched fibers from old fast - twitch dystrophic muscles are the sites of terminal damage in muscular dystrophy,» published ahead of print in the American Journal of Physiology — Cell Physiology.
Not exact matches
Muscle satellite cells from GRMD dystrophic dogs are not phenotypically distinguishable from wild type satellite cells in ex vivo culture.
Working in dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's laboratory team first identified a unique population of muscle - derived stem cells with the ability to repair muscle 8 years ago.
In vivo gene editing in dystrophic mouse muscle and muscle stem cells.
Goudenege S, Lebel C, Huot NB, et al., Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation.