Sentences with phrase «dystrophy model mice»
Excitingly, the in vitro expansion of MuSC cultures in the presence of PFI - 2 increased the yield and maintained the self - renewal capacity of MuSCs, and following transplantation into injured tibialis anterior muscles of muscular dystrophy model mice, boosted MuSC engraftment and overall therapeutic efficacy.
http://www.stemcellsportal.com/ Not exact matches
Researchers have used CRISPR to treat an adult mouse model of Duchenne muscular dystrophy.
In their research, authors Sajedah M. Hindi, Ph.D., and Ashok Kumar, Ph.D., discovered that removing TRAF6 depletes Pax7, resulting in reduced muscle regeneration in both normal and Duchenne muscular dystrophy (DMD) mouse models.
UT Southwestern Medical Center researchers successfully used a new gene editing method to correct a mutation that leads to Duchenne muscular dystrophy (DMD) in a mouse model of the condition.
The team also showed that they could recover muscle growth and function in mouse models of muscular dystrophy, a disease with a known gene mutation.
A trace substance in caramelized sugar, when purified and given in appropriate doses, improves muscle regeneration in a mouse model of Duchenne muscular dystrophy.
Because the anticancer compound works by binding to troublesome expansions in DNA, the researchers decided to test whether it would work in cells and a mouse model of myotonic dystrophy type 1.
Scientists also tested the drug in a mouse model of muscular dystrophy, since prednisone is normally given for this disease.
Complementing its extensive capabilities, PsychoGenics offers a variety of validated mouse models including in - licensed transgenic models that support research in areas such as Alzheimer's disease, Huntington's disease, Parkinson's disease, Autism spectrum disorders, psychosis / schizophrenia, Spinal Muscular Atrophy (SMA), muscular dystrophy and other muscle disorders.
Polyglutamine - expanded ataxin - 7 antagonizes CRX function and induces cone - rod dystrophy in a mouse model of SCA7.
Finally, we show that addition of small molecule inhibitors of eIF2α dephosphorylation to muscle stem cell cultures permits their ex vivo expansion and engraftment into a preclinical mouse model of Duchenne muscular dystrophy.
The researchers used several mouse models for muscular dystrophy, carrying out experiments in parallel.
Full paper title: Sensorimotor control of breathing in the mdx mouse model of Duchenne Muscular Dystrophy http://onlinelibrary.wiley.com/doi/10.1113/JP274792/full
The mouse strain is a novel model of progressive muscular dystrophy.
The go - to model for studying Duchenne muscular dystrophy (DMD) has been so - called mdx mice, a mutant strain discovered in the early 1980s.
A group of researchers have published in study in the journal Science in which they report the use of CRISPR - cas9 genome editing techniques to treat a mouse model of Duchenne muscular dystrophy.