A cure for hearing loss could be closer, now that a team of scientists has produced key
ear cells in mice — and for the first time verified that the cells work just like natural ones.
Not exact matches
Still, researchers now have a far better understanding of the molecular pathways
in the
ear and how to regenerate hair
cells and repair synaptic connections.
His research shows that
in cases of hearing loss, the
ear's nerve fibers become damaged before the hair
cells do, and when those synaptic fibers reconnect to the hair
cells, it's possible to regain hearing.
It is time we start believing
in each other and
in the physical time we have on this planet and stop blowing ourselves up, shooting at others, and preaching ridiculous social maladies (i.e., pro-life (really anti-life), anti-stem
cell, anti-gay, anti-evolution, anti-big bang, anti-truth) that is imposing a theocratic political and social environment on the rest of us who hold reality near and
ear to our hearts.
Street graffiti artists have been at work on much of the wall space, and Budapest citizens» clad these days more often than not
in jeans and leisure garb» stroll along,
cell phones clutched to their
ears.
Usually it's fatherly advice stuff like «the 10 habits of financially secure people» or a list of the safest cities
in America... sometimes it's cautionary stuff like how my
cell phone might explode
in my
ear type of thing — he usually circles the title of those to make sure I get the point — but lately he's gotten into sending me recipes, and I love it.
A particularly effective treatment against many cancers, platinum - based chemotherapy, has the unfortunate side effect of damaging the hair
cells in the
ear that are responsible for sensing sound waves, Goldrich said.
Those
cells affect skin color,
ear cartilage, facial bone formation, and the adrenal glands, which produce stress hormones and testosterone — all of which differ
in domesticated and undomesticated animals.
CIB2, which is short for calcium and integrin - binding protein 2, is essential for the structure of stereocilia, the structures at the top of the sensory hair
cells in the inner
ear.
Genetic variations most strongly associated with high scores were found near the GATA2 gene — involved
in the development of inner
ear hair
cells and the inferior colliculus.
We perceive sound after vibrations
in the inner
ear are detected by «hair
cells» and transmitted to the brain as electrical signals.
Specialized sensory neurons
in the inner
ear, called hair
cells, are responsible for the detection of sounds, and this information is transmitted to the auditory cortex via several intermediate structures.
The new model overcomes a long - standing barrier to accessing hair
cells, the delicate sensors
in the inner
ear that capture sound and head movement and convert them to neural signals for hearing and balance.
TWO types of human
ear cell have been grown
in the lab from fetal stem
cells.
Previous approaches were only marginally effective as they reached one set of hair
cells in the inner
ear, but another subset — equally critical for hearing — remained largely impenetrable.
Instead, we gave it a vehicle to travel
in, making it better capable of navigating the terrain inside the inner
ear and accessing previously resistant
cells,» said Maguire, who is also co-senior author on the study.
Using this mixture, the researchers were able to print living
cells in a specific architecture, such as an
ear shape, that maintained its form even after printing.
Further
in the future, similar
cells might be delivered to damaged
ears to restore hearing.
The pairing of the two delivered the breakthrough solution, the researchers said, as neurons responded to the molecule, regenerating synapses
in mouse
ear tissue that led to repair of the hair
cells and neurons, which are essential to hearing.
Specifically, it targets the cochlea, a snail - like structure
in the inner
ear where sensitive
cells convey sound to the brain.
«We have shown that Anc80 works remarkably well
in terms of infecting
cells of interest
in the inner
ear,» says Stankovic, an otologic surgeon at Mass..
«Supporting
cells»
in the inner
ear have more to offer than their uninspiring name suggests.
And then
in the opposite
ear, I developed Meniere's disease, which is a problem with controlling fluid inside the cochlea, progressively damaging the hair
cells there.
Recently, researchers at Cornell University
in New York printed an artificial
ear and seeded it with
cells from cows.
Even though experts know the condition is primarily due to the loss of hair
cells in the inner
ear (among other factors), they remain no closer to figuring out how to prevent it.
One recent hypothesis is that changes
in how neural crest
cells work could lead to common characteristics shared by domestic animals, such as floppy
ears, juvenile faces and spotted coats (SN: 8/23/14, p. 7).
The study, which will be published March 7
in the Journal of Experimental Medicine, suggests that CDK2 inhibitors prevent the death of inner
ear cells, which has the potential to save the hearing of millions of people around the world.
It wasn't until 2014, however, that researchers offered a single explanation for the phenomenon of floppy
ears, smaller teeth, tameness and other «domestication syndrome» traits: a mild deficit
in neural crest
cells.
Another approach to regrowing the hair
cells is to use embryonic stem
cells, with research
in this area led by Stefan Heller and colleagues at the Massachusetts Eye and
Ear Infirmary
in Boston, US.
«Because 85 percent of people
in the study reported extending the antenna during calls, we might have expected to find a disproportionate cluster of tumors behind the eye and the
ear on the side the
cell phone was used since radiation emission is highest at the antenna,» says co-author Mark Malkin, a neuro - oncologist at Memorial Sloan - Kettering Cancer Center.
Heller's team produced the inner -
ear hair
cells by exposing embryonic
cells in the lab to chemical factors which steer the natural development of hair
cells.
The therapy promotes the regrowth of crucial hair
cells in the cochlea, the part of the inner
ear which registers sound.
The
cells of Hensen and canal of Hensen, both
in the inner
ear, were named
in his honor.
In mice whose ears were blocked, cells in the auditory nerve started to use their supplies of neurotransmitter more freel
In mice whose
ears were blocked,
cells in the auditory nerve started to use their supplies of neurotransmitter more freel
in the auditory nerve started to use their supplies of neurotransmitter more freely.
Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and
Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafne
Ear and Harvard Medical School have created a new mouse model
in which by expressing a gene
in the inner
ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafne
ear hair
cells — the sensory
cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.
To deliver the healthy gene, the team inserted it into an engineered virus called adeno - associated virus 1, or AAV1, together with a promoter — a genetic sequence that turns the gene on only
in certain sensory
cells of the inner
ear known as hair
cells.
«When sensory hair
cells in the
ear die, they are not repopulated.
In the inner
ear of vertebrates, the balance system consists of three semicircular canals that contain fluid and sensory hair
cells that detect movement of the head.
Unlike mammals, birds can quickly regenerate hair
cells in the inner
ear if they become damaged.
Kelley and his team also used mice with fluorescent markers
in different
cells of the
ear followed by next generation sequencing.
Even short - term blockages of this kind can lead to remarkable changes
in the auditory system, altering the behavior and structure of nerve
cells that relay information from the
ear to the brain, according to a new University at Buffalo study.
A microscope image shows nerve
cells that relay information from the
ear to the brain
in mice.
«We wanted to know what happens at the brainstem,
in the
cells coming from the
ear,» says Matthew Xu - Friedman, PhD, the lead researcher and an associate professor of biological sciences
in UB's College of Arts and Sciences.
They then used next generation sequencing — a state - of - the - art method to rapidly measure gene expression — to sequence and quantify the thousands of genes that are expressed
in hair
cells,
in comparison with other
cells in the
ear.
Every hair
cell in the cochlea is partnered with several neurons that convey information from the
ear to the brain
in an orderly way.
In order for birds and mammals to hear, hair cells in the cochlea — the auditory portion of the inner ear — vibrate in response to sounds and thereby convert sound into electrical activit
In order for birds and mammals to hear, hair
cells in the cochlea — the auditory portion of the inner ear — vibrate in response to sounds and thereby convert sound into electrical activit
in the cochlea — the auditory portion of the inner
ear — vibrate
in response to sounds and thereby convert sound into electrical activit
in response to sounds and thereby convert sound into electrical activity.
Many other species, such as fish and birds, can regenerate the hair
cells in their inner
ear over time and create new auditory circuits, says Klickstein.
Based on previous studies, researchers have hypothesized that recreational noise exposure might damage the circuitry between sensory hair
cells in the inner
ear and their auditory nerve targets that deliver information to the brain.
Sounds thought to cause only temporary hearing loss have destroyed nerve
cells in the
ears of mice.
It stems from tiny hair
cells in the inner
ear that are surrounded by a layer of gel.