They then transplanted progenitors of the inner
ear cells into the inner ear of embryonic normal and Connexin 30 knockout mice using glass tubes with optimized tip sizes.
To clone Snuppy, the researchers implanted nuclei from his father's
ear cells into eggs from female dogs, having removed the eggs» nuclei.
Not exact matches
This term refers to everything from a newly fertilized single -
celled egg to millions of
cells organized
into eyelids,
ears, genitals, and limbs.
Usually it's fatherly advice stuff like «the 10 habits of financially secure people» or a list of the safest cities in America... sometimes it's cautionary stuff like how my
cell phone might explode in my
ear type of thing — he usually circles the title of those to make sure I get the point — but lately he's gotten
into sending me recipes, and I love it.
The inner
ear is lined with approximately 30,000 sensitive hair
cells that convert sound energy
into electrical signals that travel to the brain.
Researchers deliver small interfering RNAs loaded
into nanoparticles
into the
ears of adult guinea pigs to regenerate hair
cells damaged by noise.
The scientists injected the USH1G gene
into the inner
ear using the innocuous AAV8 virus, which enabled them to specifically target the hair
cells.
The inner
ear comprises the hearing organ or cochlea, together with the five balance organs (the saccule, utricle and three semicircular canals), which contain the sensory
cells, or hair
cells, that detect mechanical vibrations and convert them
into electrical signals.
But when stem
cell biologist Derrick Rossi's team at Boston Children's Hospital used pseudouridine - containing mRNA to encode proteins that transformed mature
cells into stem
cells, he found quite a few
ears.
Incoming sound waves make the eardrum vibrate, and the eardrum delivers these vibrations using the ossicles to the inner
ear where hair
cells translate them
into electric signals sent to the brain.
To deliver the healthy gene, the team inserted it
into an engineered virus called adeno - associated virus 1, or AAV1, together with a promoter — a genetic sequence that turns the gene on only in certain sensory
cells of the inner
ear known as hair
cells.
In order for birds and mammals to hear, hair
cells in the cochlea — the auditory portion of the inner
ear — vibrate in response to sounds and thereby convert sound
into electrical activity.
The Technion team hopes to deploy Virob
into the
ears of people suffering from hearing loss, stimulating nerve
cells that lie beyond the reach of cochlear implants.
As reported in the new study, the researchers were able to postpone the onset of hearing loss and associated hair
cell degeneration by about a month, providing enough time to inject normal copies of the Clarin - 1 gene
into the
ear before the onset of hearing loss to see if the treatment was effective.
The stem
cell research world was set on its
ear 29 January when Japanese and American scientists reported an astoundingly simple way to generate stem
cells that can theoretically develop
into all of a body's
cells.
The current research team, which includes Dr. Minoda and Dr. Hiroki Takeda of Kumamoto University, and several researchers from Keio University, have successfully grafted human iPS - derived
cells into the inner
ear of embryonic mice, a feat with a high level of technical difficulty.
Want to restore hearing by injecting stem
cells into the inner
ear?
So - called hair
cells in the inner
ear convert sounds
into neural signals that are relayed to the brain by spiral ganglion neurons, the study notes.
The question now, he says, is whether the procedure can be fine - tuned to allow more efficient production of the relay neurons — currently, fewer than 20 % of the stem
cells treated develop
into those
ear neurons.
Stem
cells from human
ears have successfully been grown
into chunks of cartilage that could replace the synthetic materials currently used in surgery.
Furthermore, this study revealed that
cells derived from humans can be grafted
into the heterozygous inner
ear of mouse embryos.
Then, they implanted the neuron precursor
cells into the
ears of gerbils with damaged
ear neurons and followed the animals for 10 weeks.
The inner
ear turns sound waves
into electrical signals inside the organ of Corti, which is lined with rows of 15,000 to 20,000 hairlike
cells.
Scientists have enabled deaf gerbils to hear again — with the help of transplanted
cells that develop
into nerves that can transmit auditory information from the
ears to the brain.
The implant was inserted
into a guinea pig's inner
ear and the electrodes attached to both sides of cochlear
cell membranes.
Durdu, a PhD student in Darren Gilmour's lab at EMBL, found this behaviour in specific groups of
cells in the zebrafish: the
cells that will develop
into the animal's «lateral line», a series of
ear - like organs along the fish's flank that allow it to sense changes in water pressure.
A team of scientists from the Howard Hughes Medical Institute (HHMI) at Baylor College of Medicine has discovered the gene responsible for triggering embryonic
cells in the inner
ear to develop
into...
Given that there are millions of
cells in a typical skin biopsy (researchers used skin from either the end of the tail or from the
ear of the mouse), that translates
into thousands of stem
cells, each one capable of developing
into any
cell type of the body.
PCR analysis of the genomic DNA demonstrated extensive contribution of injected iPS
cells into various organs including the eyes,
ears, tail, claws, kidneys, liver, lungs, stomach and guts.