Sentences with phrase «earlier age of onset»

CSA is associated with an increased risk, an earlier age of onset and more adverse course of depression, suicide attempt, impulsivity, substance abuse, and post-traumatic stress disorder.3

A general noted trend in the literature is that earlier age of onset of child maltreatment is associated with poorer mental health outcomes.

It also tends to have an earlier age of onset than depression.

More than 36 CAG repeats in the huntingtin gene will always lead to HD symptoms, if a person lives long enough, and longer CAG repeats tend to produce an earlier age of onset.

«Our findings are complementary to earlier studies that showed an association between gambling with an earlier age of onset of sexual activities, however, participants in these samples were predominantly white,» said Silvia Martins, MD, PhD, Mailman School associate professor of Epidemiology, and first author.

Genome - wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene «SP110 nuclear body protein'that was associated with increased risk of developing DM and early age of onset.

This is something that will take some time to address, but with an early age of onset you have better chances at success if it's caught early and nipped in the bud.

The autoimmune disease myasthenia gravis was eliminated based on the early age of onset and an absence of AChR antibodies in serum and AChR - bound antibodies in the muscle.

The relationship between early age of onset of initial substance use and engaging in multiple health risk behaviors among young adolescents

Some specifiers, such as CU traits (or LPE DSM - 5 specifier), as well as early age of onset of symptoms and comorbidities, should promote more timely referrals, assessments, and possibly an intensive treatment, and follow - ups.

Not exact matches

The Secret Life of the Grown - Up Brain: The Surprising Talents of the Middle - Aged Mind (Viking) is a roundup of the most recent science on how the human brain ages, as well as a guide to «toning up your brain circuits» to better weather the onset of age — which is itself a relatively new problem for humankind, writes author Barbara Strauch, The New York Times «s deputy science and health and medical science editor, whose earlier book, The Primal Teen, considered the teenage brain.

Tragically, Jarman died in March of 2011 at age 60 following a long battle with early onset Alzheimer's disease.

Wenger who had been a God, morphed, under the temptation of huge salary assurances and supreme power gifted to him by an owner and a board without honour and crucially, any understanding of modern football, into a tinpot dictator, ageing and descending into early onset dementia, rather like Robert Mugabe.

The onset of breast development begins at an earlier age in girls with a higher BMI (Body Mass Index) and this may increase the child's risk of breast cancer later in life.

The odds of any DeMoe harboring the mutation are 50 — 50, and if the mutation is present, the chances of developing early - onset Alzheimer's — the type that erodes memory before age 65 — are 100 percent.

But in essence, the same molecular mechanisms may account for the delayed age of onset of illnesses, such as schizophrenia, in early adulthood, says Dr. Petronis.

As explained in DSM - 5, age of onset is now set at 12, rather than an earlier age, to reflect the importance of clinical presentation during childhood for accurate diagnosis, while also acknowledging the difficulties in establishing precise childhood onset retrospectively.

(A rare early - onset form of the disease guarantees a person develops Alzheimer's at a young age after inheriting even one copy of certain genes.)

They also found that among early - onset users, the concurrent consumption of cannabis and alcohol was 50 % and 30 % more frequent, respectively, compared with late - onset users, defined as those who began using cocaine at or over the age of 18.

The authors anticipate that health care providers will use the early - detection biomarkers to test for their presence and levels in blood from pancreatic cancer patients and blood drawn from individuals with a high risk of developing pancreatic cancer, including those who have a first - degree relative with pancreatic cancer, are genetically predisposed to the disease, or who had a sudden onset of diabetes after the age of 50.

Not long after the HD gene was isolated, studies led by MacDonald, also a co-author of the current investigation, found that a variation in the number of CAG trinucleotide repeats within the HD gene, which codes for a protein called huntingtin, is the primary determinant of the age at which HD symptoms appear, with a greater number of CAG repeats associated with an earlier symptom onset.

Led by Brenda Penninx, PhD, of the VU University Medical Center in Amsterdam, the Netherlands, the study found that patients with an early age at onset and higher symptom severity have an increased genetic risk for MDD, bipolar disorder and schizophrenia.

An increased amount of miRNA in brain cells was correlated with a younger age at disease onset and an earlier age at death of the patients.

While the genes themselves do not result in early onset menopause, variations of the genes — CYP3A4 * 1B and CYP1B1 * 3 — were found to increase the risk of entering menopause at an earlier age in white smokers.

Carriers of the apolipoprotein (ApoE) ɛ4 allele are at greater risk for developing late - onset Alzheimer's disease (AD), develop AD at an earlier age, and experience a more severe cognitive decline and shorter survival times.

Seven of 10 studies indicated a mild - to - moderate association of PTSD with earlier mortality, consistent with an early onset or acceleration of aging in PTSD.

Age of onset varies considerably, but learning delays and clumsiness may emerge in early childhood, followed by progressive loss of brain function, including loss of motor control, hearing, speech and cognition.

Many suspect this inflammation drives the early onset of aging - related conditions such as dementia and cardiovascular disease.

Higher IGF2 methylation was also associated with higher ADHD symptoms between the ages of 7 and 13, but only for children who showed an early onset of conduct problems.

Individuals who carry this ε4 variant of APOE are at increased risk for developing Alzheimer's disease, early age of Alzheimer's disease onset, and more rapid progression of Alzheimer's disease symptoms.

They found that cases of ovarian cancer linked to genes inherited from the paternal grandmother had an earlier age - of - onset than cases linked to maternal genes, and were also associated with higher rates of prostate cancer in fathers and sons.

In Yarumal and the surrounding state of Antioquia, 5000 people carry a gene mutation which causes early - onset Alzheimer's — half of them will be diagnosed by the age of 45, and the other half will succumb by the time they are 65.

The potential for early diagnosis and delaying the onset of motor or cognitive decline by perhaps ten years is of potentially profound importance in an aging society.»

Our approach differs from that adopted by Charlesworth [61], [62], who developed mathematical models to formalize the mutation accumulation hypothesis [63] that, together with the antagonistic pleiotropy hypothesis [3], [64], may be used to show how senescence can evolve by the accumulation of deleterious alleles through mutation - selection balance at frequencies that increase with their age of onset; such mutations enhance reproductive performance early in life but diminish survival late in life through physiological trade - offs.

The results from the study showed that men who reported earlier or later onset of puberty than their peers had a poorer semen quality and smaller testicles at age 19 years of age.

Although many people think of Alzheimer's disease as something that only affects older adults, there are actually two types of Alzheimer's disease: late onset (also called typical) Alzheimer's which affects people over the age of 60 and early onset Alzheimer's, which is defined by symptoms that begin before age 60.

Diagnosed with in a very rare early - onset, slow - progressing form of Amyotrophic lateral sclerosis (ALS; also known as motor neurone disease or MND) in 1963 at age 21, he was gradually left him wheel chair bound.

Interestingly, while most cases of Parkinson's are idiopatic, or sporadic PD, the disorder is called early - onset or young - onset when the individual is diagnosed before the age of 50.

Following a period of intensive meditation, genes involved with the infectious cycle may get downregulated along with related host genes regulating protein synthesis, an explanation that is supported by other stress reduction interventions that have shown increased innate antiviral activity, such as upregulated Type 1 interferon activity.40 Shorter telomeres in population - based studies have been predictive of earlier onset of chronic diseases of aging, including diabetes, 41 cardiovascular disease9 and certain cancers.42

(6) Following this initial test of abrogating the early, age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early - aging» phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).

BubR1 insufficiency causes early onset of aging - associated phenotypes and infertility in mice.

Drug - addiction may trigger early onset of age - related disease, due to drug - induced multi-system toxicity and perilous lifestyle, which remains mostly undetected and untreated.

More than 20 % of the general population have been shown to be positive for the variants in the deCODE MI ™ test, and these individuals have roughly double the likelihood of early onset heart attack — that is, prior to the age of 50 in men and 60 in women — compared to those without the risk variants.

In families affected with SCA1, the number of CAG repeats increases with each generation, correlating with increased severity and an earlier age of disease onset.

To test whether clinicoanatomic heterogeneity in AD is driven by the involvement of specific networks, network connectivity was assessed in healthy subjects by seeding regions commonly and specifically atrophied in three clinical AD variants: early - onset AD (age at onset, < 65 y; memory and executive deficits), logopenic variant primary progressive aphasia (language deficits), and posterior cortical atrophy (visuospatial deficits).

Familial or early - onset Alzheimer's disease is inherited and develops in people between the ages of 30 and 60.

They suggest that age at onset of ambulation could be a primary outcome measure in clinical trials involving treatment in early infancy.

Distinct brain volume changes correlating with clinical stage, disease progression rate, mutation size, and age at onset prediction as early biomarkers of brain atrophy in Huntington's disease

It is known that motor abnormalities in CAG 94 KI and CAG 140 KI mouse models are present from an early age, with a delayed onset observed in the CAG 94 KI model as compared to CAG 140 KI; in addition, overt behavioral deficits were observed after 2 years of age in the CAG 140 KI mouse model (Menalled et al., 2003, Hickey et al., 2008).

It is usually found in early onset cases, before the ages of 35 to 45, when there are no other identifiable causes.