Sentences with phrase «earlier animal models»

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

School of Veterinary Medicine researchers first described simian and feline immunodeficiency viruses in monkeys and cats, which became the earliest animal models for AIDS research.

Not exact matches

Earlier studies involving animal models did not translate to humans.

Animal Models of Early Life Stress: Implications for Understanding Resilience.

When the more powerful models are applied to these datasets, one finds that the sponges are indeed the earliest diverging animal group,» he says.

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

Next, Ubogu and his team looked at an animal model of AIDP where they were able to block CD11b early in the disease process.

The identification of these genetic defects has fed back to create ever more realistic animal models of the diseases, as mentioned earlier for Huntington's disease.

In the new study, Professor Pisani and colleagues used cutting edge statistical techniques (Posterior Predictive Analyses) to test whether the evolutionary models routinely used in phylogenetics can adequately describe the genomic datasets used to study early animal evolution.

An earlier study used reversible lesions in the BNST and CeA to block the function in these two areas and then examined their effects in a unique animal model of cocaine self - administration.

Until this discovery, there was no effective animal model of the early - pregnancy events that precipitate preeclampsia.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

Working with an animal model, the researchers found that a type of cell present in the brain's primary processing area during early development, long thought to form structural scaffolding with no role in transmitting sensory information, may conduct such signals after all.

«Novel radiotracer measures olfactory neurons in animal models: Tracking deterioration in sense of smell could provide early diagnosis of neurodegenerative disease.»

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

Early treatments in animal models in vivo with hotter lasers didn't work as well.

We also want to use this system to explore which substances could counteract the progress of neurodegeneration in the brain without having to use animal models at this early stage.

Early exposure to BPA (bisphenol A)-- an additive commonly found in plastic water bottles and soup can liners — causes an increased cancer risk in an animal model of human prostate cancer, according to University of Illinois at Chicago researcher Gail Prins.

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

The model shows that if animals are still doing what they did before habitat damage caused by decades of agricultural intensification, then large, early - nesting species such as great tits will be fine, but late - nesting species such as tree sparrows will decline.

By revealing skin sensitisation or an adverse reaction that may not be identified by use of an animal or computer model, the assay can provide vital information which will allow a drug company to make informed decisions earlier saving significant development costs.

Animal models and clinical trials have shown that antioxidants and anti-inflammatory drugs could not only reduce symptoms associated with the disorders but also prevent the appearance of neurobiological abnormalities and transition to psychosis if given early during brain development.

«We know from animal models that there are critical periods during early development when cells are rapidly dividing and forming the circuitry through which cells will communicate with each other to form various tissues of the body,» said Retha Newbold, a reproductive biologist at the National Institute of Environmental Health Sciences in North Carolina.

«We wanted to develop a newborn screen for NPC because we know that the earlier we intervene with investigational treatments in animal models of the disease, the longer the animals live,» said Ory, the Alan A. and Edith L. Wolff Distinguished Professor of Medicine.

When he was still an experimentalist in the early 1970s, he began to explore mathematical models of animal behavior in tests that focused on the way animals make choices.

Studying these symptoms earlier in the animal model gives researchers more time to monitor the progression of the disease as well as assess the efficacy of potential therapeutics and to determine if and when the course of the disease could be altered.

So far, early efforts to treat the chronic inflammation with a drug in an animal model of traumatic brain injury have revealed promising results.

Animal models also can help at earlier steps in the creation of new medicines.

My interest and expertise in immunotherapy started in early 1990s with animal models of IL - 2 and IL - 15 cytokines and natural killer cell development, continued with high dose IL - 2 studies and subsequently Phase I - III trials with both CTLA - 4 and PD1 / PDL -1 checkpoint inhibitors.

In this case, the mouse is the SAMP8 mouse, a spontaneous animal model for early memory loss, which is accompanied by Alzheimer's diseaselike pathology.

They initiated their Phase 1 BIIB054 trial in 2015, and reported promising early results of its use in an animal model of Parkinson's back in the summer of 2016, but have never published the results, issued press releases, or held conference calls to share their findings with the wider public.

Novocell also demonstrated earlier this year, that hES - derived pancreatic progenitorsdevelop into human islet cells capable of producing insulin in response to glucose and ameliorating diabetes in animal models.

Both recent experience with immunotherapy for clearance of Aβ in AD, and their own (and Prothena's) experience with AS - clearing immunotherapies in animal models, indicate that in order to be effective as disease - modifying agents when administered alone, therapies that remove proteinaceous aggregates from the brain must be initiated in the early clinical or even preclinical stages of the disease, before the burden of other forms of aging damage becomes entrenched.

«Scientists had identified and diagrammed these circuits in the late 80s and early 1990s, but there had been no way to test their function in animal models,» explained Dr. Kreitzer.

Each uses a different approach to targeting these malformed proteins, and is supported by data in animal models — and the early human evidence looks favorable, if very preliminary.

Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert in tumor vasculature, to investigate the virus's mechanism of action in animal models.

To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.

To test our hypothesis we determined whether early estrogen deficiency is associated with heightened intraocular pressure, RGC loss and glaucoma in an animal model.

These are neurons in the eye that respond to decrements in light that we discovered in an animal model are especially vulnerable early stages of the disease.

«We already knew that the buildup of fibrin appears early in the development of MS — both in animal models and in human patients, so we wondered whether thrombin activity could in turn serve as an early marker of disease.»

Earlier this summer, for instance, we hosted a course for early career scientists in which leading scientists in aging biology shared knowledge and taught techniques to study aging in diverse animal models.

Beyond expanding researchers» ability to study problems in traditional animal models, CRISPR is also facilitating work in animals that couldn't be modified by earlier gene - editing technologies.

SAN FRANCISCO, CA — Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)-- a form of early - onset dementia that is similar to Alzheimer's disease.

[18] In animal models, studies have also shown that exposure to atrazine both early and late in pregnancy can have developmental effects on mammary tissue in the exposed fetus that can persist into adulthood.

After years of experimenting with FMD in animal models and showing its benefits on metabolism and life span, Dr. Longo's team analyzed the effects in a human clinical trial that was published earlier this year.

Earlier research of the flavonoids» positive effects, especially anthocyanidins, are restricted to very small studies in older individuals or animal models, but have revealed that cognitive function is improved with greater intake of foods with these compounds.

Earlier studies involving animal models did not translate to humans.

Moreover, models of experimental carcinogenesis in animals have shown the potential to modify a number of metabolic actions and steps in the cell cycle in a way that early events in the cascade of cancer development may be counteracted while stages of progression may be slowed down.

On the basis of these consistent and robust data from animal models, a recent report in European dieters found a significant association between the timing of lunch and weight - loss effectiveness, with earlier lunch times linked to greater success (45).

Much of medical science derived for human treatment programs is based on earlier research involving animal models.