Sentences with phrase «earlier disease settings»

«The survival benefit is clearly significant and supports future efforts to study multiple targeted therapies in earlier disease settings.

The effectiveness of the concomitant approach demonstrated in this definitive study also indicates the importance of future clinical studies that seek greater clinical benefit through the study of multi-targeted approaches in earlier disease settings.»

The DNA itself appears in the form of a repeating sequence, and the more repeats there are, the earlier the disease sets in.

Not exact matches

Gyan, who enjoyed a successful stint at the Stadium of Light but is best known for his exploits at the 2010 World Cup, was set to lead his team out for the crucial group stage clash, but is likely to sit this one despite having been released from hospital after just one night because the disease was caught so early.

So now, with late - stage clinical failures piling up, the U.S. Food and Drug Administration (FDA) has set off down a path to adapt those standards as researchers are pushed inexorably into earlier and earlier forms of the disease, ahead of the brain damage inflicted by Alzheimer's.

Future refinements should sharpen the method's ability to accurately identify Alzheimer's disease at an early stage — prior to the onset of clinical symptoms — in a primary care setting, with just a simple blood extraction.

Also, Alzheimer's diagnosticians might be wise to their adopt cancer colleagues» early detection stance, she said, as Alzheimer's disease appears to start long before amyloid - beta plaque appears and cognitive decline sets in.

Mild cognitive impairment sets in at a median age of 44 in people carrying the mutation, and full - blown dementia at 49, decades earlier than is common with the more typical sporadic form of the disease.

As an example, Martinez - Trujillo suggests a video game could be developed for memory training and testing of senior citizens, perhaps suffering from early signs of Alzheimer's disease, set in a real - world environment like a grocery store to provide a more realistic series of challenges for the participant.

Though trastuzumab and pertuzumab have increased response rates and improved outcomes in HER2 - positive breast cancer, 30 % to 40 % of early - stage patients treated in the neoadjuvant setting will have residual disease at the time of surgery.

One of the rare variant burden genes, TIMP3, was previously associated with Sorsby's fundus dystrophy, a rare disease similar to AMD but with earlier on set and Mendelian inheritance.

These range from visual stimulation experiments that allow us to tap into the specific sets of retinal ganglion cells that are most vulnerable early in the disease, to the evolution of new imaging techniques, largely thanks to Alf Dubra and Vivek Srinivasan's work in those areas, and the ability to image retinal ganglion cells and their component parts like their axons which degenerate very early in glaucoma.

The team will continue to develop and test an imaging - based biomarker that can be used in a clinical setting to enable us to understand the molecular changes to the ganglion cells, so we can detect the disease very early on.

A study last year found that obese children and teens have as much plaque in their arteries as a 45 - year - old adult, setting them up for heart disease and other serious health conditions much earlier than their parents.

In Ayurveda, there are several early warning signs when an imbalance is present, and these happen long before an actual labeled disease or illness sets in.

Her thesis, Alzheimer's Disease: A comparison study of early on - set dementia and simple carbohydrates from soda consumption is evidence of her knowledge.

Early - life stressors are known to induce changes in gene expression that set the stage for disease in later life.30 Thus, unfortunately, exposure to mercury in either parent, even prior to conception, can affect the child's own genetic expression.

About Site - This is my journal of sorts in dealing with Early On Set Alzheimer's Disease.

Early on, this based - on - real - events drama sets its course on two narrative paths: one that follows King (Helen Hunt) and her team during their nearly two - decade quest to find that cancer - related genetic link, and another that follows Annie Parker (Samantha Morton), a Toronto wife and mother whose family is shattered brutally and repeatedly by the disease.

Our approach to achieving this goal focuses on three objectives: (1) to develop a reliable, predictive panel of biomarkers (including both biological and bio-behavioral measures) that can identify children, youth, and parents showing evidence of toxic stress, and that can be collected in pediatric primary care settings; (2) to conduct basic, animal and human research on critical periods in development and individual differences in stress susceptibility, thereby informing the timing and design of a suite of new interventions that address the roots of stress - related diseases early in the life cycle; and (3) to build a strong, community - based infrastructure through which scientists, practitioners, parents, and community leaders can apply new scientific insights and innovative measures to the development of more effective interventions in the first three postnatal years.

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Huge, explosive fires are becoming commonplace, say many experts, because climate change is setting the stage — bringing higher temperatures, widespread drought, earlier snowmelt and spring vegetation growth, and expanded insect and disease infestations.

Avoidable death rates among the Maori, for example, are estimated to be almost double those of Europeans or other New Zealanders.3 Many indigenous people have one or more of a complex set of interlocking chronic diseases from a comparatively early age.9 Although these diseases are diagnosable and treatable, at least some of this avoidable mortality remains underdiagnosed and undertreated.

African American adolescents living in high - poverty urban settings are at increased risk for early sexual initiation and sexually transmitted diseases.