The application is on hold, the agency has told him, as NIH reconsiders its rules for the kind of experiments he wants to do: mixing human stem cells into very
early animal embryos and letting them develop, a strategy that could produce tissues or organs for transplantation.
► The U.S. National Institutes of Health (NIH) has put funding on hold for experiments that involve «mixing human stem cells into very
early animal embryos and letting them develop» while it «reconsiders its rules» for this type of research, Gretchen Vogel reported Wednesday.
Not exact matches
Under a 2015 moratorium, the National Institutes of Health does not fund research that transplants human stem cells into
early embryos of other
animals.
The Dawn of the Deed By John A. Long When paleontologist Long spotted a set of tiny bones inside a 380 - million - year - old fossilized fish, he not only discovered the oldest known
embryos, he also found the
earliest known evidence of
animals copulating directly, rather than releasing sperm and eggs to meet in the open sea.
When researchers create «chimeric» mice by injecting iPS cells into
early - stage mouse
embryos, the resulting
animals are unusually prone to cancer.
The researchers speculate that the act of reprogramming adult cells to pluripotency may induce the expression of cell - surface molecules the immune system has not seen since the
animal (or person) was an
early embryo.
In previous work Tufts University developmental biologist Michael Levin found that patterns of electrical potentials in the
earliest stages of an
embryo's development can direct how an
animal's body grows, and that manipulating those potentials can cause a creature to sprout extra limbs, tails or functioning eyes.
Earlier this year he and his colleagues identified a new type of human pluripotent stem cell that seems to be especially good at contributing to
animal embryos.
He still believes the spheres he studied in 1993 are the
embryos of
early animals and argues that the peanut - shaped fossils represent a different, unrelated organism.
But scientists have not managed to isolate such cells from farm
animals, and must rely instead on injecting genes randomly into
early embryos.
Researchers led by Professor Eckhard Wolf, Chair of Molecular
Animal Breeding and Biotechnology at the Gene Center and the Department of Veterinary Sciences at LMU, now report in the journal PNAS, that
early phases of the development of bovine
embryos, might offer a better system for the understanding of the
earliest differentiation steps.
But we do know that, like other
animals, the human
embryo in its
earliest stages consists of three main components known as germ layers: the ectoderm, the endoderm and the mesoderm.
Instead, NIH had seen «indications» that «scientists are considering exploring the use of human pluripotent cells in
early stage
animal embryos,» including to grow human tissues or organs.
That and other concerns led the National Institutes of Health to announce in 2015 that it would not fund experiments that put human pluripotent stem cells, those with the ability to morph into almost any kind of tissue or organ, into the
early embryos of other
animals.
If approved after a 30 - day comment period, the new policy would allow the National Institutes of Health to fund researchers who want to put stem cells in
early - stage
animal embryos to study disease, possible therapies and organ transplants.
Summary: Extremely powerful genes that govern the shape of an
embryo from the
earliest stages of development have been tinkered with by nature over the course of evolution to create the enormously wide range of
animal forms, scientists report in the August 14, 1997 issue of Nature.
Extremely powerful genes that govern the shape of an
embryo from the
earliest stages of development have been tinkered with by nature over the course of evolution to create the enormously wide range of
animal forms, scientists report in the August 14, 1997 issue of Nature.
There are also putative bilateral
animal embryos, some of which appear to be in an
early stage of cellular division.
Some of these possible
animal embryos apparently record the
early stage of cellular division.
Under the proposed NIH policy, taxpayer funds would be allowed for experiments in which human cells are added to
early - stage
embryos of all
animals except nonhuman primates, such as chimpanzees and monkeys, because they are so similar to humans.
August 14, 1997 Evolution re-sculpted
animal limbs by genetic switches once thought too drastic for survival Extremely powerful genes that govern the shape of an
embryo from the
earliest stages of development have been tinkered with by nature over the course of evolution to create the enormously wide range of
animal forms, scientists report in the August 14, 1997 issue of Nature.
A coalition of Britain's leading medical charities had
earlier urged MPs to approve stem cell research using human -
animal hybrid
embryos.