Sentences with phrase «early biomarkers of»

Jerskey's most recent research involved the utility of neuroimaging techniques in identifying early biomarkers of disease, in addition to research exploring the subtle neuronal changes either to differentiate patient populations or to track changes over time.

Distinct brain volume changes correlating with clinical stage, disease progression rate, mutation size, and age at onset prediction as early biomarkers of brain atrophy in Huntington's disease

• the identification and validation of early biomarkers of autoimmunity and their use to help identifying population at risk of developing autoimmunity;

She has been involved in the identification of early biomarkers of placental damage in cohorts of patients at high risk of pregnancy complications, with specific focus on the role of autoimmunity and of vascular inflammation.

Several large - scale, federally funded epidemiological studies are under way to pinpoint possible environmental triggers, as well as early biomarkers of autism.

«This confirms that while unique to each individual, some aspects of the family connectome are inherited and maintained throughout development and may be useful as early biomarkers of mental or neurological conditions,» said lead author Oscar Miranda - Dominguez, Ph.D., research assistant professor of behavioral neuroscience, OHSU School of Medicine.

Accordingly, the currently identified miRNA - like fragment may function as an early biomarker of EVD to advance the diagnosable window and reduce the difficulties in the isolation and treatment of patients who develop suspicious symptoms.

Not exact matches

Support a multi-year effort led by world - class scientists to develop a blood test for earlier detection of breast cancer when survival rates are the highest, known as the EIF Breast Cancer Biomarker Discovery Project.

Intake of rice early in childhood has not been well characterized in the United States, and there are only limited data from other regions of the world.5, 6 Moreover, biomarker concentrations of As among infants consuming rice are virtually unknown.

A benefit of greater sensitivity means earlier detection of biomarkers for disease, but it also brings up the issue of how to define baseline biomarker presence.

Recently, DNA shed from tumor cells has been identified as a noninvasive method of screening biomarkers for the early diagnosis and prognosis of cancer.

Through their analysis the researchers detected damaged proteins in characteristic patterns in the samples of those patients with early and advanced OA and RA, but were found at markedly lower levels in the samples of those in the control group — providing the researchers with the identifiable biomarkers necessary for early detection and diagnosis.

The research, «Protein oxidation, nitration and glycation biomarkers for early - stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease,» is published by Arthritis Research and Therapy.

Biomarkers could revolutionize the early detection of and therapy for Alzheimer's disease.

«Adding these two biomarkers provided statistically significant improvement for all early stage cancer versus healthy controls as well as other subcohorts when used with the current gold standard biomarker, CA 19 - 9,» said Ann Killary, Ph.D., professor of Translational Molecular Pathology.

Adding two blood - borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

With obesity rates climbing during the past 20 years within the United States and colon cancer being the second - leading killer of men and women in the nation, these facts compelled Fenton and her team to conduct research which could identify the specific biomarkers of obesity and early - stage colon cancer and help in prevention efforts.

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

Genetically reprogramming late - stage human cancer cells to a stem - cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.

«ASL is a promising alternative functional biomarker for the early diagnosis of Alzheimer's disease,» Dr. Meije Wink said.

The authors anticipate that health care providers will use the early - detection biomarkers to test for their presence and levels in blood from pancreatic cancer patients and blood drawn from individuals with a high risk of developing pancreatic cancer, including those who have a first - degree relative with pancreatic cancer, are genetically predisposed to the disease, or who had a sudden onset of diabetes after the age of 50.

A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research from the Perelman School of Medicine at University of Pennsylvania.

A team led by Ken Zaret, PhD, director of the Penn Institute for Regenerative Medicine and the Joseph Leidy Professor of Cell and Developmental Biology, and Gloria Petersen, PhD, from the Mayo Clinic, identified a pair of biomarkers that physicians could soon use to discover the disease earlier.

Many cancer researchers focus on biomarkers that could provide diagnostics for the early detection of cancer.

Scientific American spoke with geneticist and oncologist Amanda Paulovich, director of the Fred Hutchinson's Early Detection Initiative, about the work she and her team are doing to find biomarkers that can identify cancer in its most formative stages.

The members of the initiative hope to improve early detection of cancer by making an impact in a variety of areas, including doing epidemiologic studies on risk factors, developing new and improved methods of diagnostic imaging, discovering and verifying new biomarkers as indicators of cancer, and developing new technologies to aid early detection.

The next stage of the research will involve examining the signals that the placenta sends to the mother to affect the way she uses the nutrients she ingests, potentially providing important clues about biomarkers which provide an early warning of pregnancy complications.

Two other big initiatives fared better: a proteomics effort to identify proteins in blood and other biomarkers that might work as early warning signs of cancer, and the most recent: a human Cancer Genome Atlas.

This abnormality specific to autistic children may therefore constitute a biomarker for the disease that could enable their earlier diagnosis and management, as from the age of two years.

Blood biomarkers appear to be an early - warning signal for the accelerated loss of lung function and airway obstruction in firefighters who responded to the World Trade Center disaster, according to new research published online in the Annals of the American Thoracic Society.

By identifying and profiling molecules that differ between different forms of dengue, the researchers lay the foundations for finding biomarkers present at early - stage dengue that are able to predict disease development.

«Biomarkers may provide early warning of lung problems in 9/11 firefighters.»

«Specifically, we are looking at the effects of these early factors on later levels of C - reactive protein (CRP), a biomarker associated with risk for cardiovascular and metabolic disease,» Metzger said.

«If we can find biomarkers informing us that the most vulnerable parts of the lung have already been infected by RSV, then it could be possible to identify much more quickly the children at more risk for developing severe lung disease and to get those babies in a treatment protocol at an earlier time,» Pickles said.

Early attempts to measure biomarkers or analytes in spit were hampered by inconsistent results and lack of recognized economic benefit to companies developing immunodiagnostics.

«Using innovative data normalization and gene selection approaches, we combined the statistical power of multiple genomic studies and masked their variability and batch effects to identify robust early diagnostic biomarkers of pancreatic cancer,» said first author Manoj Bhasin, PhD, Co-Director of BIDMC's Genomics, Proteomics, Bioinformatics and Systems Biology Center and Assistant Professor of Medicine at HMS.

In order for early intervention of addiction to be possible, the study has deemed it essential to identify the biomarkers which may make a person more vulnerable to drug addiction, due to these particular areas of the brain affecting decision making and impulsivity.

«The identification and initial validation of a highly accurate 5 - gene pancreatic cancer biomarker panel that can discriminate late and early stages of pancreatic cancer from normal pancreas and benign pancreatic lesions could facilitate early diagnosis of pancreatic cancer,» said co-senior author Roya Khosravi - Far, PhD, Associate Professor of Pathology at BIDMC.

However, in the early stages of disease these «biomarkers» can be difficult to detect, as they are relatively rare.

Detecting important biomarkers in lower concentrations will allow patients to be treated earlier for diseases such as some cancers and neurological disorders, which could increase the chance of survival rate.

In previous studies, the same group along with others had demonstrated that microRNAs (miRNAs) produced by eukaryotic cells and viruses are present in human blood in highly stable, cell - free forms and these so called circulating miRNAs can serve as non-invasive biomarkers for the early diagnosis of various diseases, including viral diseases.

New protein biomarkers would ideally show specific brain pathologies and act as early indicators of disease.

«These splicing signatures could potentially be used as clinical biomarkers to detect blood stem cells that show signs of early aging or leukemia, and to monitor patient responses to treatment,» said Crews.

If the findings hold up across different autoimmune diseases, it's possible that the characteristic patterns of Xist localization could be used as a disease biomarker, enabling earlier diagnoses and treatment.

Our findings provide potential targets and new biomarkers for intervening or blocking early spread of viral infection,» she said.

High levels of two novel urinary biomarkers early in critical illness are associated with adverse long - term outcomes in patients with acute kidney injury (AKI), according to an international, multi-center study led by University of Pittsburgh School of Medicine Researchers.

Such biomarkers raise the possibility of early diagnosis, since levels of certain compounds differ between healthy people and patients with NPC, even before the onset of symptoms.

The majority of evidence fell into three categories: biological indicators or biomarkers, such as leukocyte telomere length (LTL), earlier occurrence or higher prevalence of medical conditions associated with advanced age and premature mortality.

«New biomarker of brain inflammation in early - stage Alzheimer's disease.»

«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»