Sentences with phrase «early cancer cells»

«One is that it sheds light on how premalignant and early cancer cells are able to withstand the assault of chemotherapy and other treatments,» he says.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

Not exact matches

A veteran of digital imaging technology, in 1999 he founded Quantitative Imaging Corp. (QImaging), a manufacturer of digital cameras for scientific and industrial uses — the kind, for example, that can detect microscopic, early - stage cancer cells.

She demonstrated that early experience leads to lasting changes in the molecular structure of the brain and discovered a gene involved in the spread of brain cancer cells into healthy brain tissue.

Vaz and Baylin say the results suggest that early epigenetic changes triggered by chronic cigarette smoke exposure can build up over time and make the airway cells increasingly sensitive to responding to mutations that initiate cancer.

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer develoCancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer develocancer development.

An implant of genetically engineered skin cells has been designed to grow darker in colour when it detects early breast, prostate and colon cancers

Shown here is an image of early stage - prostate cancer where the cancer cells lack the PTEN and INPP4B genes.

Recently, DNA shed from tumor cells has been identified as a noninvasive method of screening biomarkers for the early diagnosis and prognosis of cancer.

Seeking one mechanism to explain the induction of cancer by many different agents, Huebner and Todaro had suggested that retrovirus oncogenes are a part of the genetic baggage of all cells, perhaps acquired through viral infection early in evolution.

When researchers create «chimeric» mice by injecting iPS cells into early - stage mouse embryos, the resulting animals are unusually prone to cancer.

Earlier this year, Feinberg led a study that considered this view of epigenetics in metastatic pancreatic cancer cells.

Factors secreted by the locations containing non-pigmented melanocytes, such as melanocyte stem cells, appear to be able to suppress early cancer development.

If melanoma is caught early, before cancer cells leave the skin and move to lymph nodes and the rest of the body, patients have a 91.5 percent 5 - year survival rate.

The identification of the cancer cell of origin has important clinical implications, as it enables doctors to detect malignancies earlier and predict tumor behavior more accurately.

Natural killer cells — which destroy cancer cells and pathogens — also help early fetuses grow, a finding that may lead to treatments to prevent miscarriage

Scientists investigating the earliest stages of cancer development used an exquisitely sensitive sequencing method capable of detecting DNA mutations present in as few as 1.6 per cent of blood cells, to analyse 15 locations in the genome, which are known to be altered in leukemia.

Swollen lymph nodes are often the earliest sign of metastatic spread of cancer cells.

Bowel cancer, also called colorectal cancer, results from a series of genetic changes (mutations) that cause healthy cells to become progressively cancerous, first forming early tumors called polyps that can eventually become malignant.

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resisCancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resiscancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.

One earlier study investigated how cancer cells attempt to strike a balance in the density of the fibrous netting surrounding them.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

In the early 1990s, in vitro tests on cancer cells by Lane and his colleagues hinted that some compounds could restore mutant p53's normal function.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

Adding two blood - borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Instcancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Instcancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer InstCancer Center reports in the Journal of the National Cancer InstCancer Institute.

«Especially in early stages, normal cells can kill cancer cells,» says biologist Yasuyuki Fujita, who led the British team.

A paper he published early this year in the Journal of Clinical Oncology describes a dendritic cell vaccine in advanced glioma, an aggressive form of brain cancer.

Genetically reprogramming late - stage human cancer cells to a stem - cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.

«This means we can predict which of the cancer cells are getting aggressive and spread, at a much earlier stage than today.»

Just two weeks earlier Porter and his colleague Carl June had injected three leukemia patients with genetically modified versions of their own immune cells to seek and destroy their cancer.

Once stem cells can be grown and differentiated in a controlled way to replace degenerated cells and repair tissues, medical science may then be able to diagnose and cure many intractable diseases at their earliest stages, such as type 1 diabetes, Parkinson's disease, various cardiovascular diseases, liver disease, and cancer.

If a breast cancer line had silently contaminated Klonisch's cell culture early on, it would have been subject to the usual technique for immortalizing a normal cell (which involves applying enzymes, antibiotics and antibiotic - resistant genes).

It also means that the role of telomere biology at a very early step of cancer development is vastly underappreciated,» said senior author Dirk Hockemeyer, a UC Berkeley assistant professor of molecular and cell biology.

When cancer cells start dividing rapidly to form tumors, these cells are actually reverting to an earlier time in their development when they were supposed to divide rapidly.

In earlier studies, Ruggero found that myc not only drives protein production, but also that myc - driven cancer cells become absolutely dependent upon this ability to make abnormal amounts of protein.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

They elaborate on several focus areas described by the White House earlier: preventive vaccines, early detection, single cancer cell genomics, immunotherapy, pediatric cancer, and data sharing.

The work also reinforces the importance of finding tumor cell clusters in the blood as a mechanism of detecting cancer metastasis earlier.

Aifantis, the chair of the Department of Pathology at NYU Langone and a member of its Perlmutter Cancer Center, and an early career scientist at the Howard Hughes Medical Institute, says experiments in his laboratory had shown that leukemia - initiating cells concentrate in the bone marrow near CXCL12 - producing blood vessels.

The study builds on Polyak's earlier research finding that women already identified as having a high risk of developing cancer — namely those with a mutation called BRCA1 or BRCA2 — or women who did not give birth before their 30s had a higher number of mammary gland progenitor cells.

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

Several earlier studies have attempted to eliminate cancer cells from biopsy tissue, but they showed contradictory results.

By interfacing brain cells onto graphene, researchers at the University of Illinois at Chicago have shown they can differentiate a single hyperactive cancerous cell from a normal cell, pointing the way to developing a simple, noninvasive tool for early cancer diagnosis.

It is difficult to detect cancer cells in the blood at an early stage: About one malignant cell is encountered per billion of healthy cells.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

This shows promise for breast cancer patients as diagnosing and treating the breast cancer at early stages means there is a greater chance of preventing cancer cells spreading to other tissues, such as the lungs, brain and bone.

Cancer cells are known to circulate throughout the body even in early stage invasive disease.

Adds Liu: «With metastatic cancers accounting for around 90 % of deaths from solid tumors, the hope is that one day a device that can enable the analysis of single tumor cells circulating in the blood could make a big difference in early diagnosis, detection and monitoring of numerous types of cancer, without invasive biopsies.»

Inflammation also erodes telomeres, the «caps» at the ends of chromosomes that protect genes from degradation, which can lead to early cell death, premature aging and even cancer.