Sentences with phrase «early cell cycle»

Papagiannakis et al. performed metabolite and cell - cycle measurements in single cells to show that the cell cycle is a higher - order function, which emerges from the collective synchrony between an autonomous metabolic oscillator, a biomass formation oscillator (early cell cycle), and a biomass segregation oscillator (late cell cycle).

Not exact matches

By copying the gene for Spo0F (purple) early in the cell - division cycle and the gene for KinA (green) later in the cycle, the bacteria assure that the decision to form a spore or divide is made when DNA replication has completed.

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

But in addition to these factors, Hunt, who won a share of the 2001 Nobel Prize in physiology or medicine (along with Leland Hartwell and Paul Nurse) for his discovery of cyclin, a key regulator of the cell cycle, emphasizes early independence and playfulness.

Earlier this year, Kiyomitsu, working in Cheeseman's lab, saw that during the metaphase cell cycle step a dividing cell uses the motor protein dynein and two signals to perfectly align the cell's mitotic spindle structure in the middle of the cell.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

Upregulated genes clustered into at least 7 functional groups, including immediate early genes or transcription factors, cell - cycle related genes, stress - responsive protein genes, cell signaling protein genes, cell adhesion and cell surface protein genes, genes involved in translation and protein turnover, and genes encoding metabolic proteins.

We show that DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle.

It was even lower in the early lesions of I10 mice than in those of age - matched virgin mice, suggesting that the molecular network activated in normal epithelia at involution to arrest the cell cycle (Figure 1 — figure supplement 3B) also operates in these premalignant cells.

This issue has confounded earlier conclusions regarding timing of ISC cell cycles.

When this cycle happens over and over again, our cells become tired and stop listening to insulin, which leads to insulin resistance, an early warning sign of diabetes.

Moreover, models of experimental carcinogenesis in animals have shown the potential to modify a number of metabolic actions and steps in the cell cycle in a way that early events in the cascade of cancer development may be counteracted while stages of progression may be slowed down.