Not exact matches
Early clinical trials indicate that restricting calorie intake seems to trigger similarly promising physical changes in people, which is why it's sometimes discussed
as a potential anti-aging intervention.
The PhD course focuses on various aspects of human (donor) milk, with
as main study a randomized
clinical trial towards the effects of human donor milk in very low birth weight infants (the
Early Nutrition Study).
Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use
as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized
clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of
early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined
as any breastfeeding), but
early pacifier use did not adversely affect exclusive breastfeeding duration.
One large
clinical trial known
as JUPITER reported in 2008 that rosuvastatin (Crestor) lowers the risk of heart attacks and other events by 44 percent in healthy subjects but experts have since raised questions about its methodology in part because the
trial was stopped
early, which might have created the effect of overestimating the drug's benefits.
Given these auspicious
early results, the team is already laying the groundwork for a
clinical trial to test RCGD 423 or a similar molecule
as a treatment for osteoarthritis or juvenile arthritis.
Fiers discovered a key protein on the influenza virus that could serve
as a target for a universal vaccine; the drug has shown promise in an
early clinical trial.
As Scientific American reported
earlier this year, more than half of the current cancer
clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the
early stages of understanding how to use such treatment on a larger scale.
«These very important
early clinical trials could provide hope for patients with all sorts of neurologic problems that involve paralysis such
as stroke, brain injury, ALS and even multiple sclerosis.»
HB 661 would permit people with chronic illness to get therapies in
early - stage
clinical trials — not just terminally ill patients,
as the state's current «right - to - try» law does.
Samuel Weiss, PhD, Professor and Director of the HBI, and Research Assistant Professor Artee Luchman, PhD, and colleagues, published their work today in
Clinical Cancer Research, which is leading researchers to start a human phase I / II clinical trial as early as Spri
Clinical Cancer Research, which is leading researchers to start a human phase I / II
clinical trial as early as Spri
clinical trial as early as Spring 2015.
Clinical trials that charge enrollees to participate are ostensibly aimed at giving patients
early access to promising therapies — often in the fields of stem cells or aging reversal — that are too unusual or have too little profit potential to get funding from traditional sources such
as companies, foundations, or the National Institutes of Health.
But Massachusetts's colleges and universities have had an eye on industry for more than a decade, Griesemer says, citing the addition of bioinformatics to computer science programs and
clinical trials training to medical school curriculums
as early examples.
In animal studies and
early clinical trials, the drug known
as Epo (for erythropoietin) appeared to counteract anemia caused by radiation and chemotherapy.
Despite lowering low - density lipoprotein (LDL), known
as «bad» cholesterol, while markedly increasing levels of high - density lipoprotein (HDL), or «good» cholesterol, a large
clinical trial to investigate the cholesterol drug evacetrapib was discontinued
early after a preliminary analysis showed it did not reduce rates of major adverse cardiovascular events, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.
Clinical trials of weight loss have been shown to improve participants» mood, but this could be a result of the supportive environment rather than the weight loss itself,
as the effects are seen very
early on in treatment and are not related to the extent of weight loss.
The research, part of a phase I
clinical trial to test the safety of the treatment, was published
as a letter to the editor in The New England Journal of Medicine
earlier this week and will be in the September issue of Human Gene Therapy.
In
early clinical trials of these drugs, we noticed that in some breast cancer patients the tumors didn't just remain the same size —
as would be expected with drugs that interfere with cell division — but began to recede, sometimes quite dramatically, said Goel.»
In my role
as a
Clinical Professor of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Professor of Medicine and Director of
Early Phase
Clinical Trials Program in the Department of Medicine at Roswell Park Comprehensive Cancer Center, I am developing novel therapies for patients with cancer.
In August 2014, KalVista Pharmaceuticals Ltd. launched an
early phase
clinical trial of a PKal inhibitor to treat DME, with Jennifer Sun, M.D., Ph.D., of Joslin's Beetham Eye Institute
as principal investigator.
For more information regarding Bristol - Myers Squibb
Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: •
Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such
as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply
As of
early 2012,
clinical trials of IL - 17 antibodies against psoriasis have shown promising results in Phase II.
PI3K inhibitors are the subject of some 100
clinical trials, including one that will test whether a cancer treatment's
early failure to reduce glucose uptake,
as measured by FDG PET, can predict whether the therapy will fail to shrink a patient's tumor.
«For those of us who saw the AIDS epidemic explode and who watched helplessly
as thousands died, the opportunity to try to develop an HIV cure is truly amazing,» said Paul Volberding, MD, a UCSF professor of medicine who started the Positive Health Program at Zuckerberg San Francisco General Hospital and Trauma Center in the
early days of the epidemic and was a leader in
early clinical trials to evaluate antiretroviral therapy.
Overall, SR - Tiget represents a multi-disciplinary research environment, which provides a unique blend of scientific expertise in the development of innovative gene and cell therapy strategies, access to relevant preclinical models to evaluate their efficacy and safety,
as well
as competence in conducting
early phase
clinical trials.
Based primarily on
clinical trials led by Arjun V. Balar, MD, assistant professor of medicine and director of the Genitourinary Medical Oncology Program, the FDA approved atezolizumab (Tecentriq ®) and pembrolizumab (Keytruda ®)
as first - line treatments for these particularly frail patients with advanced bladder cancer in
early 2017.
Promising animal studies of this method of delivering anticancer drugs, known
as intraductal chemotherapy, has led to Phase I
clinical trials in women with very
early breast cancer.
Thanks to an experimental drug from Isis Pharmaceuticals that Vivienne received six weeks
earlier as part of a phase 1
clinical trial, her parents now say she has more strength, more poise and more self - assurance.
The department has developed and produced 15 different formulations for
early clinical trials (e.g. vaccine antigens produced by heterologous expression) and has conducted more than 20
clinical trials as sponsor.
Most recently, CRI has launched a new «venture philanthropy» program called the Cancer Vaccine Acceleration Fund (CVAF)
as a means to catalyze development of next - generation therapeutic cancer vaccines and other immunotherapies by helping to address the critical shortage of capital available for
early stage
clinical trials.
As the Director of the
Early Phase
Clinical Trials Program at Roswell Park, I am responsible for developing novel therapies for many types of cancer, including melanoma.
«We are very excited about using VSV
as researchers have seen promising results using other similar viruses, such
as the polio virus, in
early clinical trials.»
People in the
early stages of dementia may be able to enroll in
clinical trials,
as well, to gain access to experimental new treatments.
Circulating testosterone levels decline with increasing age but do not appear to be significantly affected by the menopausal transition.8
As early as the 1940s, testosterone was reported not only to alleviate menopausal symptoms but also to restore libido.9 In recent years, evidence has accumulated supporting the hypothesis that the decline in endogenous testosterone levels is associated with menopausal symptoms, including decreased libido, worse moods, and poorer quality of life.10 Clinical trials have demonstrated that exogenous androgens in conjunction with estrogens can ameliorate symptoms affecting sexual function and general well - being.11, 12 In addition, studies have found beneficial effects of androgen therapy on bone mineral density.13 -
As early as the 1940s, testosterone was reported not only to alleviate menopausal symptoms but also to restore libido.9 In recent years, evidence has accumulated supporting the hypothesis that the decline in endogenous testosterone levels is associated with menopausal symptoms, including decreased libido, worse moods, and poorer quality of life.10 Clinical trials have demonstrated that exogenous androgens in conjunction with estrogens can ameliorate symptoms affecting sexual function and general well - being.11, 12 In addition, studies have found beneficial effects of androgen therapy on bone mineral density.13 -
as the 1940s, testosterone was reported not only to alleviate menopausal symptoms but also to restore libido.9 In recent years, evidence has accumulated supporting the hypothesis that the decline in endogenous testosterone levels is associated with menopausal symptoms, including decreased libido, worse moods, and poorer quality of life.10
Clinical trials have demonstrated that exogenous androgens in conjunction with estrogens can ameliorate symptoms affecting sexual function and general well - being.11, 12 In addition, studies have found beneficial effects of androgen therapy on bone mineral density.13 - 15
The press release quotes the Vice Chairman, Richard Mulligan, Ph.D,
as saying «While we may evaluate PEG - SN38 in
earlier lines of colorectal cancer treatment in future
clinical trials, at this time, resources associated with such
trials are better directed toward areas of study with nearer - term commercial potential.»
The IHDP began in 1985 and was designed
as a eight - site, randomized
clinical trial evaluating
early childhood development, center - based education, and home - based family support services,
as well
as pediatric surveillance in an attempt to reduce the risk for developmental delay, behavioral issues and health problems LBW, PT (≤ 37 weeks gestational age) infants.