Sentences with phrase «early drug development»

Lead Optimization improvement of compounds that have been identified as «leads» in early drug development.

The early drug development process often takes several years to produce drug leads.

The new San Francisco Bay Area facility will focus on drug discovery and early drug development for diseases like neurodegeneration and cancer.

Experience with DMPK and early drug development in metabolic disease, inflammation and oncology

In early drug development efforts, Longmore and his colleagues have done some preliminary work looking for small molecules that may inhibit DDR2 binding to collagen.

CHDR provides consultancy to pharmaceutical industries, with special emphasis on early drug development.

Not exact matches

Early Monday, Allergan plc Ordinary Shares (NYSE: AGN)-- one of the world's largest pharmaceutical companies that produces branded and generic drugs, and performs pharmaceutical research and development — announced its recent acquisition of Zeltiq Aesthetics.

MaRS Innovation (MI) and the Centre for Drug Research and Development (CDRD) are pleased to announce that they have entered into an agreement to collaborate on projects of mutual interest with a goal to advance and commercialize early - stage health - related discoveries.

According to the Greens, since these drugs interfere with implantation in the womb, they destroy human life in the earliest stage of development.

By reaching children at an early age and providing positive activities and encouragement, we offer successful youth development programs that addresses youth crime, gang membership, drugs, and other negative influences that affect our children daily.

A licensed Marriage and Family Therapist, Agnes spent several years working with AADAP (Asian American Drug Abuse Program), the Asian Pacific Mental Health Clinic and Shanti (Aids counseling) before coming to ECPC in 1995 for training in early childhood development.

less than or equal to lamivudine Acquired Immune Deficiency Syndrome Antiretroviral therapy, usually means 1 - 2 drugs, used in early studies Antiretroviral zidovudine (also known as ZDV) Breastfeeding Baby Friendly Hospital Initiative Breastfeeding and HIV International Transmission Study Combined antiretroviral therapy Centers for Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral Therapy, 3 or more drugs for more effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same drug as AZT)

Their first visit was to CytoCybernetics, where CEO Glenna Bett explained how her company has developed a system that uses computers and live human cells to screen drugs in their early stages of development, to determine whether they may cause any potentially deadly side effects.

They also believe that by measuring a patient's dark adaptation response time they have developed a tool that can help track the onset or progression of the disease as well as measure the effectiveness of drugs that are in development to treat the disease early on.

At least four experimental Ebola drugs were in early stages of development.

«There are significant opportunities in outsourcing to China and India, particularly in respect to drug discovery, early development, and the preclinical and clinical sectors,» Burrill says.

Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

Although these studies are only proofs of principle — many more trials must happen before a drug could be approved — they suggest that oxytocin, if delivered soon after a diagnosis of autism, could help sway early social interactions in favor of more normal development.

Furthermore, the shifts in the industry may herald a new, more fluid division of labor where nontraditional partnerships take on the earliest stages of drug development.

Namita Gandhi, director of clinical sciences, joined Regeneron in 2007, when the drug that became the immune modulator dupilumab was in early development.

Written by 25 authors, it described the collaboration between government, academic researchers, and disease advocacy groups that led to the ICV trial as a model of the teamwork that can speed drugs through early development, boosting their chances of being commercialized.

Nevertheless, Canadian job opportunities in drug discovery are on the rise, Harack declares, as the local biotechnology industry enters its «early teen» phase, growing from early stage R&D to development and commercialization.

It could in future allow the PARP inhibitor olaparib to become a standard treatment for advanced prostate cancer, by targeting the drug at the men most likely to benefit, picking up early signs that it might not be working, and monitoring for the later development of resistance.

The bill also contains $ 50 million for the Cures Acceleration Network, a drug - development program added to the health reform bill earlier this year by Senator Arlen Specter (D — PA).

«If modifying cholesterol levels in the brain early in life turns out to reduce amyloid deposits late in life, we could potentially make a significant difference in reducing the prevalence of Alzheimer's, a goal of an enormous amount of research and drug development effort.»

As early as 1969, these collaborations led to important products - directly, as with the development of diagnostics for drugs of abuse, Abuscreen; or indirectly, through the development of technologies, which later played a key role in the first isolation and characterization of the a-interferons and to Roche's patents for Roferon.

Earlier last year, the PharmBio Growth fund — which is managed by the Economic Development Board * (EDB)-- Chiron Corporation (USA), and Blue Dot Capital Pte Ltd jointly started the nation's first drug discovery company, S'Bio.

It soon paid out about $ 1 million to support early research and development for new drugs.

Although there is no cure, drugs in development are likely to work better the earlier they are given.

Still, she cautions that in allowing patients to start the drug as late as 20 weeks into pregnancy the protocol may not have been ideal for exploring whether the drug helps prevent preeclampsia; experts in placental development often suggest starting with a blood thinner as early as eight weeks, she says.

«Since this gene has previously been identified as a target for the development of new drugs, in the future, it may be possible that early detection will facilitate better management of this disease.»

Professor Geoff Pilkington, study co-author and Head of the Brain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the brain.

Awarded $ 9,948 in Charger Innovation Fund support for further development and advised by Biology Department Chair Dr. Debra Moriarity, the device's creators aim to lower production costs of testing cultures to allow drugs to be screened for failure earlier, saving on the cost of drug development.

But while LDDN focuses on the earliest stages of drug development — identifying compounds and confirming their biological activity — PharmaStart may take the process much further before signing on with a drug company.

By revealing skin sensitisation or an adverse reaction that may not be identified by use of an animal or computer model, the assay can provide vital information which will allow a drug company to make informed decisions earlier saving significant development costs.

Animal models and clinical trials have shown that antioxidants and anti-inflammatory drugs could not only reduce symptoms associated with the disorders but also prevent the appearance of neurobiological abnormalities and transition to psychosis if given early during brain development.

«FDA's approach to evaluation of recent hepatitis C drugs underscores the Agency's flexibility in considering innovative or alternative trial designs for drugs that have demonstrated highly promising outcomes in early phase development,» said Dr. Poonam Mishra, deputy director for Safety, Division of Antiviral Products / Office of Antimicrobial Products in the FDA's Center for Drug Evaluation and Research and lead author of the Hepatology paper.

Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.

It is worthwhile to give patients expensive new drugs that can cure their hepatitis C much earlier than some insurers are now willing to pay for them, according to a UC San Francisco study that models the effects of treating the disease early versus late in its development.

Early treatment with the drug may allow it to correct some impairment in neural development that contributes to ASD - like behavior in mice, the researchers said.

«Consistently applied to the design of clinical development programs, the approach presented has the potential to early identify medical and economic risks of new drugs,» says study co-author Lars Kuepfer.

November 14, 2006 Anti-cancer drug shows early promise in pulmonary hypertension A drug used to treat kidney cancer can prevent the development of pulmonary hypertension (high blood pressure in the lungs) in rodents, report researchers from the University of Chicago at the 2006 annual meeting of the American Heart Association, November 12 to15, in Chicago.

A NIH National Cooperative Drug Discovery / Development grant funded the early basic science and discovery of this investigational drug and the Alzheimer's Drug Discovery Foundation and Harrington Discovery Institute helped support some of the key toxicity studies that FDA required, Conn sDrug Discovery / Development grant funded the early basic science and discovery of this investigational drug and the Alzheimer's Drug Discovery Foundation and Harrington Discovery Institute helped support some of the key toxicity studies that FDA required, Conn sdrug and the Alzheimer's Drug Discovery Foundation and Harrington Discovery Institute helped support some of the key toxicity studies that FDA required, Conn sDrug Discovery Foundation and Harrington Discovery Institute helped support some of the key toxicity studies that FDA required, Conn said.

In the early stages of drug development, new compounds are tested on cell cultures, with the cells» responses closely monitored.

Research Interests: Clinical pharmacology of anticancer agents; early phase drug development; drug tolerability in cancer patients with HIV / AIDS; drug tolerability in cancer patients with organ dysfunction; blood - brain barrier penetration of drugs.

The Woodlands, Texas — May 11, 2006 — Lexicon Genetics Incorporated (Nasdaq: LEXG) announced today that it was awarded a grant from the United States Army Medical Research & Materiel Command (USAMRMC) for the identification of targets that may be important in the development of drugs to prevent or treat spinal muscular atrophy (SMA), a neurodegenerative disorder and the leading genetic cause of death in early childhood.

In a paper published earlier this year in the Journal of Studies on Alcohol and Drugs, researchers from Penn State University pointed out a flaw in alcohol studies based on large longitudinal study in the United Kingdom called the National Childhood Development Study.