Sentences with phrase «early embryonic development in»

We show that DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle.

«New methods such the CRISPR - Cas9 system for gene editing now make it possible to carry out functional studies in other species, and this will in turn lead to decisive advances in our understanding of early embryonic development in mammals.»

In addition, this is not the only case in which the regulatory circuits that control early embryonic development in humans show greater similarity to those employed in bovine embryos than to those that operate in the mouse system.

The mechanisms that underlie early embryonic development in humans and cattle are very similar.

Not exact matches

But the great and encouraging consequence of this breakthrough is that the humanity of the unborn child, even at the earliest embryonic stage of development, is now a subject of polite conversation even in the circles that so fanatically resisted acknowledging the facts of life.

The decision whether the maternal or the paternal version is shut down occurs early in embryonic development — one reason, why for long it was thought that the pattern of active alleles is nearly homogeneous in the various tissues of the organism.

The researchers discovered that both major living lineages of birds (the common neognaths and the rarer paleognaths) differ from the major lineages of non-bird reptiles (crocodiles, turtles, and lizards) and from mammals in having a unique, median gene expression zone of two different facial development genes early in embryonic development.

«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.

Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.

Facial asymmetries and minor physical anomalies begin to appear early in embryonic development, mainly the first trimester of pregnancy, and can be a sign of instability during this growth.

Changes in cellular metabolites have been shown to regulate embryonic stem cell development at the earliest stages of life.

«Changes in metabolites can regulate earliest stages of development: Findings may offer insights into a variety of disorders, advance embryonic stem cell research.»

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

But the new research suggests that these symptoms may be a late manifestation of a disease that originates much earlier, in the first steps of embryonic development.

She's now working on a new game, «Suddenly Cute,» in which players learn how small changes early in a vertebrate's embryonic development can lead to big differences in adults.

They hope to study APOBEC's importance in fighting off mutations early in the development of embryonic life, and in the development of the eggs and sperm that carry our genes to the next generation.

Other speakers proposed that all of these traits, from hormone levels to craniofacial features, have a common root in early embryonic development.

Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory - generated stem cells comes to mimicking embryonic cells seen in the very earliest stages of human development, known as naïve stem cells.

Scientists use OCT4 protein to reprogram adult cells into embryonic - like cells, an indication that it is involved in early development (SN: 11/24/07, p. 323).

The technique marks a major development in genetic diagnoses, which previously could not be conducted this early in embryonic development and required much larger amounts of biological material.

The researchers speculate that some cases of schizophrenia afflicting only one of a pair of identical twins could be due to mutations causing the expansion of trinucleotide repeats in the affected twin during the early embryonic development.

Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing.

Caspary's lab studies the Hedgehog pathway in early embryonic development.

During early embryonic development, XpdTTD is dominant over the Xpd † XPCS and Xpd † XP alleles, whereas later in the ontogenesis of skin, hair - shaft, and blood cells, the situation is reversed.

The gene, known as gata5, acts in embryonic cells, which are primordial, unspecialized cells that form in the earliest stage of embryonic development and are genetically programmed to evolve into one of many specialized cell types, such as skeletal muscle cells, nerve cells, blood cells, skin cells, and liver cells.

In a developing embryo PGC's can be isolated from the germinal crescent, a region in the early stage embryo where the cells form, or from the gonads at a later stage in embryonic developmenIn a developing embryo PGC's can be isolated from the germinal crescent, a region in the early stage embryo where the cells form, or from the gonads at a later stage in embryonic developmenin the early stage embryo where the cells form, or from the gonads at a later stage in embryonic developmenin embryonic development.

In the future, these cells could be molecularly manipulated to better grasp their interactions and the early embryonic development stages, hypothesizes Dr. Christos Coutifaris, president - elect of the American Society for Reproductive Medicine and a professor at the University of Pennsylvania.

Early in embryonic development, the neural crest — a transient group of stem cells — gives rise to parts of the nervous system and several other tissues.

The potential for early embryonic events to impact on adult physiology remains an important question in health and development.

Unlike embryonic stem cells from earlier in development, fetal stem cells from umbilical cord blood are multipotent - they can develop into a limited number of cell types.

Lanner is attempting to edit genes in human embryos to learn more about how the genes regulate early embryonic development.

These findings on gene expression in single embryonic stem cells are in concert with recent studies of early mammalian development, which reveal molecular heterogeneity and a stochasticity of gene expression in blastomeres.

Moreover, ES cell differentiation in vitro recapitulates events that take place during early embryonic development including the formation of the three germ layers of ectoderm, mesoderm and endoderm, and the emergence of endothelial, hematopoietic, cardiac, neuronal and hepatic or pancreatic cells [8], [9].

For example, clusters containing genes that are upregulated during the course of ES cell differentiation (Table 3) include in order of time of expression: cluster 30 that represents genes which take part in the formation of the three embryonic germ layers during gastrulation, i.e., Goosecoid, Cerberus like 1 homolog, Wnt3, Mesp1, Mixl1, mEomes and Even - skipped 1; cluster 15 containing molecular regulators of early mesoderm development including Bmp2, Bmp5, Msx1, Msx2, Cripto, Tbx20, Hey2, Smad6, Vegfr2 (Kdr), Foxf1 and Hand1; cluster 20, which comprises regulatory and structural genes linked to hemopoiesis such as Gata1, Nfe2, Klf1, Tie1, hemoglobins (Hba - x, Hbb - b1) and Glycophorin A; cluster 12, which is rich in genes involved in cardiac development, e.g., Mef2c, Myl4, cardiac Troponin T2, Tropomodulin 1, myosin binding protein C, Bves, Angiopoietin 1 and Angiopoietin 2; and, cluster 4, which consists mostly of genes associated with neuronal development and differentiation, for example, Neurog1, Neurog2, Olig2, Nkx6.1, Neurod4, Pou3f2, Pou3f4, Cacna2d3, Cacng4, Kcnq2 and EphA5.

These genes have been also implicated in the gastrulation phase of embryogenesis [55] indicating that «Time Series» clusters provide a comprehensive collection of genes expressed at specific stages of ES cell differentiation and early embryonic development.

It has also been reported that Kap1 controls endogenous retroelements during early embryonic development and in embryonic stem cells but not in adult fibroblasts [45].

The neural tube is formed early in the embryonic development — before some women even know they are pregnant.

In the luteal phase, progesterone differentiates the endometrial stroma, increases glandular secretions, and changes the pattern of uterine proteins to produce an environment supportive of early embryonic development.

In a developing embryo PGC's can be isolated from the germinal crescent, a region in the early stage embryo where the cells form, or from the gonads at a later stage in embryonic developmenIn a developing embryo PGC's can be isolated from the germinal crescent, a region in the early stage embryo where the cells form, or from the gonads at a later stage in embryonic developmenin the early stage embryo where the cells form, or from the gonads at a later stage in embryonic developmenin embryonic development.