Sentences with phrase «early endoderm»

Here we use a transgenic allele designed to detect low level transcription in the primitive endoderm lineage as a tool to identify an immediate early endoderm - like ES cell state.

Not exact matches

Two other members of this family, Ndr1 and Ndr2, are required to form the mesoderm and endoderm early in zebrafish development.

The researchers found that maternal gdf3 is required for Ndr1 and Ndr2 to signal at the levels necessary to properly induce the formation of mesoderm and endoderm cells in early zebrafish embryos.

The pluripotent cells of the embryo organize themselves at an early stage in germ layers: the endoderm, mesoderm and ectoderm.

But we do know that, like other animals, the human embryo in its earliest stages consists of three main components known as germ layers: the ectoderm, the endoderm and the mesoderm.

Endoderm cells are a type of cell found in the early embryo, and which eventually mature into the body's major organs — including the pancreas, the home of β - cells.

The researchers came upon their finding serendipitously, after working out the molecular pathway, or succession of genes, that prompt the early - stage formation of the endoderm, one of the three layers of cells that form the developing embryo.

Endoderm cells are a type of cell found in the early embryo, and which eventually mature into the body's major organs — including the pancreas, the home of ß - cells.

Taken together our data support the notion that the reversible and immediate early PrEn state marked by low - level transcription at the Hex locus is biased towards the formation of extra-embryonic endoderm.

The ability of Nanog to suppress early Hex positive endoderm states is consistent with both the mutually exclusive nature of Nanog and Gata6 expression in vivo [17] and the ability of Nanog to suppress Gata6 positive PrEn differentiation, in vitro [39].

One of these cells types, characterized by both the expression of the Venus transgene and the ES cells marker SSEA - 1 (V+S +), appears to represent an early step in primitive endoderm specification.

However, cells derived from the early epiblast are only able to contribute to embryonic lineages and not those derived from the PrEn [18]--[20], while PrEn cells can only contribute to their own lineage by colonizing the visceral and mostly parietal endoderm in chimera experiments [20]--[22].

Moreover, ES cell differentiation in vitro recapitulates events that take place during early embryonic development including the formation of the three germ layers of ectoderm, mesoderm and endoderm, and the emergence of endothelial, hematopoietic, cardiac, neuronal and hepatic or pancreatic cells [8], [9].

Differentiation into extraembryonic endoderm [21] or neural progenitors [33] are frequent early outcomes of spontaneous differentiation when human ES cells are cultured in the presence of a feeder cell layer, and it is interesting to speculate that the cells are being primed for these fates.

We have previously reported that our 26 - d protocol closely recapitulates key stages of biliary development, starting with the differentiation of hPSCs into endoderm and subsequently into foregut progenitor (FP) cells, followed by the generation of hepatoblasts (HBs), cholangiocyte progenitors (CPs) expressing early biliary markers and mature CLCs displaying cholangiocyte functionality.

Specifically the disputed question is whether Toddler acts early, to enhance Nodal signaling, and therefore to specify endoderm cells; or, alternatively, whether it acts later, to control the migration of mesendoderm.

This name refers to the fact that the early embryo of bilaterians (the blastula stage) is generally composed of three primary germ layers: the ectoderm (outer layer), the endoderm (inner layer), and the mesoderm (middle layer) between them.