Sentences with phrase «early endosome»

Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.

Here we show that the internalized IFNAR1 and IFNAR2 subunits of the IFNAR complex are differentially sorted by the retromer at the early endosome.

Cbl Controls EGFR Fate by Regulating Early Endosome Fusion.

Akhila Chandrashaker (Zerial, MPG)-- «Systems analysis of early endosome motility through identification of molecular motors» (2010)

The early endosome contains the Rab GTPase Vps21 (yellow) and the CORVET tethering complex.

Our studies on the molecular mechanisms of endocytosis led to the discovery that the small GTPase Rab5 is a master regulator of early endosome biogenesis.

Identification of the expressed form of human cPLA2β: cPLA2β3 is a novel variant localized to mitochondria and early endosomes.

Protein kinase C$ ẹlta $ and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2 / 3 complex and cortactin.

We now aim at unraveling molecular and functional links between endocytic sorting at the plasma membrane and retrograde sorting on early endosomes.

The Johannes group has made two major contributions in this context: the discovery of a membrane trafficking interface between early endosomes and the Golgi apparatus, and the demonstration that dynamic protein - induced glycosphingolipid reorganization acts as a driving force for membrane invagination in clathrin - independent endocytosis.

In the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.

Not exact matches

Rink, J., Ghigo, E., Kalaidzidis, Y., and Zerial, M. Rab conversion as a mechanism of progression from early to late endosomes.

The molecular mechanisms underlying early / recycling endosomes - to - TGN transport are still not understood.

Thus, our study shows that membrane exchange between the early endocytic and the biosynthetic / secretory pathways involves specific components of the Rab and SNARE machinery, and suggests that retrograde transport between early / recycling endosomes and the endoplasmic reticulum is critically dependent on the sequential action of two members of the Rab6 subfamily.