Sentences with phrase «early gene expression»

Provided data analysis that included statistics package development with staff statisticians, and high throughput assay advent and development (immediate early gene expression); Taq - man primer - probe research and design using primer express.

Jordan Francke: Using Immediate Early Gene Expression to Investigate Rapid, Non-Genomic Effects of Testosterone on Carassius auratus Visual Processing in the Optic Tectum

Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon - alpha2b stimulation.

Not exact matches

The evidence for epigenetic effects on emotion regulation is quite solid: Early caregiving experiences can affect the expression of the genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.

The researchers discovered that both major living lineages of birds (the common neognaths and the rarer paleognaths) differ from the major lineages of non-bird reptiles (crocodiles, turtles, and lizards) and from mammals in having a unique, median gene expression zone of two different facial development genes early in embryonic development.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

The trick is to run the tape of evolution over again: to intervene in the development of a chicken embryo, for instance, to reverse evolution, rolling back the clock to manifest earlier patterns of gene expression.

When his team looked at gene expression changes in the mice, then applied them to humans with early stage cancer, the results revealed a breakdown of which patients have a high or low chance of survival.

When the researchers started taking weeds out of the corn at early points, such as when the corn had as few as two and four leaves, they still saw differences in gene expression when compared to corn without weeds.

Booij and her colleagues hope that this study will shed more light on the specific role of early environmental influences on brain development, gene expression and emotional regulation.

Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner.

A necklace of early stage developing wings, each labeled fluorescently to reveal a different pattern of gene expression.

In the new study, the team genetically inactivated HIV - 1 in transgenic mice, reducing the RNA expression of viral genes by roughly 60 to 95 percent, confirming their earlier findings.

Lead author Johan den Boon, associate scientist with the Morgridge Institute for Research at the University of Wisconsin - Madison, says the research team used gene expression profiling on 128 specimens from the Study to Understand Cervical Cancer Early Endpoints and Determinants, or SUCCEED.

«New major gene expression regulator in fungi: Researchers report prevalent DNA base modification in the earliest fungal lineages.»

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

Indeed, this is true in some cases such as eye color, a characteristic that is determined by gene expression early in development.

The variant lies near a gene called telomerase RNA component, or TERC, and earlier studies in animals have shown that low TERC expression is associated with shorter telomeres, and faster biological aging.

«These findings raise the possibility that by determining the gene expression profile of a patient's tumor, physicians may be able to identify aggressive disease at the outset of diagnosis and start treatment earlier,» said Sungyong You, PhD, an instructor in the Cedars - Sinai Department of Surgery and the first author of the study.

«This is the first example of how early environment can alter gene expression without mutating the gene itself,» Jirtle says.

A study carried out by the Laboratoire Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS / Aix - Marseille Université), in collaboration with clinicians from Marseilles Public Hospitals (AP - HM) and scientists from the Salk Institute in San Diego (US), has revealed a new gene that plays a crucial role during early development in humans and whose under - expression may induce certain autistic traits.

In a Cell paper published on April 7, Lanner's team analysed gene expression in 88 early human embryos and is using those data to identify genes to disrupt in embryos using CRISPR — Cas9.

«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»

For example, the researchers were able to identify previously unknown gene expression differences between the neural stem cells that give rise to the brain's deep structures versus its neocortical surface, and to show that molecular signatures of different neural cell types arise much earlier in brain development than previously realized.

Through analyzing several datasets of prostate cancer cases and patient outcomes, the researchers found that a high level of expression of two genes, TOP2A and EZH2, was associated with early recurrence of prostate cancer and metastatic spread, leading to an increased risk of death.

The Center for RNA Research at the Institute for Basic Science has succeeded in revealing, for the first time, the mechanism of how miRNAs, which control gene expression, are regulated in the early embryonic stage.

Analysis of the most aggressive of these cells revealed a pattern of gene expression distinct from that known to occur in breast - to - bone metastasis, as described in an earlier paper by Massagué.

They remained activated long after the gene expression had turned off or gone down in the control animals, thus confirming the earlier observation that the virus causes the immune system to overreact.

Oncologists welcome gene expression profiling tests as an added tool in deciding whether women with early - stage breast cancer should have chemotherapy, a new study has found.

The researchers hope that these assays will be used by many laboratories that are studying the events associated with early embryonic development and the effect of repeat length and methylation status on gene expression and differentiation.

While expression levels of all marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the expression profile induced by caACVR1 Q207D displayed evidence of advanced chondrogenic differentiation as shown by decreased levels of the early differentiation stage marker collagen type II together with enhanced expression of the later - stage markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).

The serum response factor and a putative novel transcription factor regulate expression of the immediate - early gene Arc / Arg3.1 in neurons.

Early investigations into the nature of genetic evolution proposed two potential mechanisms for the origin of new features: gene duplication and divergence, and regulatory changes in gene expression.

This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.

Ectopic expression of retinoic acid early inducible - 1 gene (RAE - 1) permits natural killer cell - mediated rejection of a MHC class I - bearing tumor in vivo.

Patricia Heyn (Neugebauer, MPG)-- «Nuclear architecture and gene expression during early zebrafish development» (2013)

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

Earlier this year, expression of 1 of 5 anti-CRISPR genes were found to inactivate the Type I - F CRISPR / Cas system of

Early in vitro analyses of gene expression revealed that the cell lines were germ - cells, our target cell type.

Changes in the manipulation medium, as well as a move from late to early stages after first appearance of pronuclei, produced blastocysts which were statistically indistinguishable from those produced in normal IVF by measures of morphology, ploidy and gene expression.

In collaboration with Margarita Salas (CBM - CSIC), in bacteriophage φ29 we examine the transcriptional regulator p4 that functions as a switch between early and late gene expression during the infection cycle.

Pozhitkov et al. 29 described an increased expression of epigenetic regulatory genes, hypothesizing that the activation of these genes reveals the nucleosomes and allows for the later transcription of developmental genes that have no early expression.

Some tissues (e.g., muscle) exhibit an early response, with most genes that change expression doing so right after death (Supplementary Fig. 6).

Mesoderm invagination, the first morphogenetic movement of gastrulation in the early Drososphila embryo, is controlled by the expression of the twist and snail genes.

I would like to research how chromatin modulation alters gene expression during early stages of differentiation using computational biology and experimental approaches.

Alterations to local chromatin insulation strength at TAD borders represented an early reprogramming event and often preceded changes to gene expression

Consistent with our earlier findings analyzing OCT3 / 4 and NANOG gene expression, both promoters were hypermethylated and hypomethylated in hNSCs and hESCs, respectively (Figure 3B).

High - density oligonucelotide arrays were designed to target the computationally predicted 3 ′ UTRs of OR and VR genes and probe the expression of all receptors annotated in an early genome assembly [9], [31].

Among the early germ cell markers examined, VASA is a candidate gene for detecting pre-meiotic germ cell differentiation from monkey ES cells, because its expression is detected earlier in the primordial stage of germ cell development in comparison to that of PIWI family genes in vivo in mice and humans [11], [36]--[38], [49].

Venus positive cells experiencing low - level transcription at the Hex locus, but still expressing the ES cell markers SSEA - 1 and Oct4, show elevated levels of PrEn gene expression and reduced levels of early ICM markers such as Nanog.