Sentences with phrase «early lesions»
"Early lesions" refers to the initial stages or small signs of damage or illness in the body. It refers to the early development of health problems, which can be detected before they become more serious. Full definition
Of note, by 6 months post involution, as few pSTAT5 + cells (5.7 ± 2.2 %) could be detected in early lesions of parous mice, as in virgin mice (p = 0.3; n = 4 mice; data not shown), suggesting that with time, parity - induced elevated levels of pSTAT5 in parous mice subside.
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Since pSTAT5 + cells occur at 10-fold higher frequency than pSTAT3 + cells in early lesions from our mouse model (18 % vs 1.8 %), C188 - 9 is effectively a STAT5 inhibitor in this setting.
Apoptosis levels were inversely correlated with levels of pSTAT5 in early lesions from these two groups of mice (Figure 4 — figure supplement 2B).
and can be useful in revealing early lesions.
The analysis by our unique collaboration indicates that the cancer risk in these relatively benign early lesions is determined by the number of abnormal clones that has been established in the Barrett's mucosa, rather than by specific gene abnormalities.»
They say the results led them to conclude that each of the women's cancers began with mistakes in STIC or earlier lesions located in the fallopian tubes.
pSTAT5 is detected in human breast early lesions, especially in women who have had a pregnancy; therefore, prophylactic therapy targeting Jak2 - STAT5 signaling may lower breast cancer risk in high risk women.
When these Stat5a − / − mice were bred to MMTV - tva mice, infected with RCAS - caErbb2, impregnated 4 days post infection, and analyzed at I10, the resultant early lesions exhibited significantly lower levels of pSTAT5 than did the lesions in Stat5a + / + mice (Figure 5A) confirming the predominance of STAT5a in the mammary gland.
Of note, AG490 did not affect pSTAT1, pSTAT3 or pSTAT6 positivity in either parous or virgin early lesions (Figure 6 — figure supplement 1B).
Indeed, the inactivated form of GSK3β, pS9 - GSK3β, was readily detected by immunohistochemistry in caErbb2 - initiated early lesions in parous mice while it was not found in normal mammary cells (Figure 3E).
Clinical Findings and Lesions: Early lesions of interdigital furunculosis may appear as focal or generalized areas of erythema and papules in the webbing of the feet that, if left untreated, rapidly develop into single or multiple nodules.
Magnetic resonance imaging (MRI) and computed tomography (CT) have an increased sensitivity for the diagnosis of discospondylitis and can be useful in revealing early lesions.
«Cancer cells by definition have high mutation rates and genomic instability even at the very earliest stages, so you could imagine building a virus that could destroy even the earliest lesions and be used as a prophylactic,» says O'Shea.
It can pick up early lung cancers and can reduce mortality from lung cancer by about 20 %, but a large number of the early lesions that are seen probably never would go on to being lethal cancer and being able to discriminate between those that will cause trouble and those that won't make a huge difference in cancer therapy.
MRI scans show that the early lesions have stopped spreading.
The number and size of early lesions were also similar in parous vs virgin Stat5a − / − mice (Figure 5C, D).
It was even lower in the early lesions of I10 mice than in those of age - matched virgin mice, suggesting that the molecular network activated in normal epithelia at involution to arrest the cell cycle (Figure 1 — figure supplement 3B) also operates in these premalignant cells.
In addition, in any virgin mouse, some of the early lesions had relatively high percentage of pSTAT5 cells, and they correspondingly showed reduced levels of apoptosis (Figure 4 — figure supplement 2).
Among the experimental MMTV - tva virgin mice that were euthanized at 8.5 weeks post RCAS - caErbb2 infection (described in Figure 1C — E), a small subset (20 %) exhibited high baseline levels of pSTAT5 in both the normal mammary epithelium and early lesions, while the rest had barely detectable pSTAT5 in either (Figure 4 — figure supplement 2A).
Together, these findings suggest that Jak2 signaling is required for early lesion survival and progression and that blocking the upstream tyrosine kinase activity of STAT5 can prevent the progression of early lesions in parous mice.
However, despite their very low apoptotic rate, the early lesions of I10 mice harbored abundant numbers of cells positive for p53, Bax, and Bak (data not shown), suggesting that as in virgin mice oncogene - activated cells in parous glands are fully capable of activating p53 and its pro-apoptosis targets, but these precancerous cells nevertheless evade apoptosis.
(H) Early lesions in parous mice treated either with DMSO or C188 - 9 were identified by immunohistochemical staining for the HA tag of RCAS - caErbb2, and their areas were then quantified using ImageJ.
It has been proven that animal protein can literally turn on and off the development of tumors or early lesions that lead to tumors.
Early lesions can be removed by freezing or surgery.