Sentences with phrase «early lesions of»

Clinical Findings and Lesions: Early lesions of interdigital furunculosis may appear as focal or generalized areas of erythema and papules in the webbing of the feet that, if left untreated, rapidly develop into single or multiple nodules.

It was even lower in the early lesions of I10 mice than in those of age - matched virgin mice, suggesting that the molecular network activated in normal epithelia at involution to arrest the cell cycle (Figure 1 — figure supplement 3B) also operates in these premalignant cells.

Not exact matches

Early diagnosis of high risk lesions permits more effective and less traumatizing treatments.

Evidence of placental abruption as a chronic process: Associations with vaginal bleeding early in pregnancy and placental lesions.

This pilot research builds on an earlier study by Milovancev and collaborators that examined the ability of MRIs and CT angiograms to detect cancerous lesions related to FISS, and another study that looked at three methods for assessing margins for canine mast cell tumors and soft tissue sarcomas.

An earlier study used reversible lesions in the BNST and CeA to block the function in these two areas and then examined their effects in a unique animal model of cocaine self - administration.

«The identification and initial validation of a highly accurate 5 - gene pancreatic cancer biomarker panel that can discriminate late and early stages of pancreatic cancer from normal pancreas and benign pancreatic lesions could facilitate early diagnosis of pancreatic cancer,» said co-senior author Roya Khosravi - Far, PhD, Associate Professor of Pathology at BIDMC.

After demonstrating and independently validating that a 5 - gene pancreatic cancer predictor discriminated between cancerous and healthy tissue, the researchers applied the predictor to datasets that also included benign lesions of the pancreas, including pancreatitis and early stage cancer.

The analysis by our unique collaboration indicates that the cancer risk in these relatively benign early lesions is determined by the number of abnormal clones that has been established in the Barrett's mucosa, rather than by specific gene abnormalities.»

Genetically analysing lesions in the food pipe could provide an early and accurate test for esophageal cancer, according to research led by Queen Mary University of London (QMUL), Academic Medical Center in Amsterdam and Arizona State University.

When performed in tandem, two molecular biology laboratory tests distinguish, with near certainty, pancreatic lesions that mimic early signs of cancer but are completely benign.

Moradian - Oldak will couple the MMP - 20 discovery with another study published Nov. 2 in the Journal of Biomedical Engineering and Informatics, which concluded an amelogenin - chitosan hydrogel could repair early tooth decay by growing an enamel - like layer that reduces lesions by up to 70 percent.

An initial clinical trial of simvastatin in people with early - stage MS showed reductions in brain lesions, suggesting an effect on the underlying disease process.

The results showed that all nine patients lost identical regions of chromosome 17, where the cancer - linked p53 gene is located, in each of the cancer samples, including the early - stage STIC lesions, suggesting that the «misprinted» or flawed p53 gene is an early step in ovarian cancer development.

They say the results led them to conclude that each of the women's cancers began with mistakes in STIC or earlier lesions located in the fallopian tubes.

Midwestern corn growers know the symptoms of northern corn leaf blight all too well: greenish - gray lesions on the leaves that can add up to major yield losses if not detected and treated early.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

By improving lower extremity blood flow, early percutaneous revascularization of the target lesion gives an impulse to patient mobility and quality of life in the short - term.

Screening colonoscopy reduces colorectal cancer death risk through detection and treatment of early cancerous or precancerous lesions (adenomas) but its effectiveness depends on examination quality, which is measured by adenoma detection rates (ADRs).

In a study of 51 patients, researchers used a state - of - the art microfluidic device to capture circulating pancreas epithelial cells in 33 percent of patients with early pancreatic lesions and no clinical diagnosis of cancer.

CFSs now appear as preferential targets for oncogene - induced replication stress in precancerous lesions, which suggests that their instability promotes oncogenesis from early stages of the process.

Diagnosis of early Lyme disease by polymerase chain reaction amplification and culture of skin biopsies from erythema migrans lesions

The autopsy study revealed that an additional 8 % of children in late childhood or early adolescence had progressed beyond the fatty - streak stage and had developed more advanced, focal lesions.

is a translational program whose goal is to integrate prevention, screening, early diagnosis and effective treatment of oral cancer and its precursor lesions into a province - wide seamless network.

It can pick up early lung cancers and can reduce mortality from lung cancer by about 20 %, but a large number of the early lesions that are seen probably never would go on to being lethal cancer and being able to discriminate between those that will cause trouble and those that won't make a huge difference in cancer therapy.

Harold Varmus: Well the simplistic way to think about that is and I'm not sure this is the way it will be worked out, is to be able to take just a few cells from those early lesions and examine them genetically or for other kinds of marks on the DNA that would predict whether or not this is some - this is a lesion which might or an early stage growth that might never be able to progress, but it is also possible that every early tumor of that kind has some probability of expanding and invading and growing to become a medical problem, so getting that right will obviously be crucial because it's very difficult to say when you've diagnosed something that is an early stage tumor that it won't progress.

Early signs of antitumor activity at 14 weeks after initiation of treatment have been observed in metastatic visceral and nonvisceral lesions, according to a case report.

New discoveries in early detection and molecular oncology, including the creation of the Lung Nodule Clinic, a translational laboratory for early detection and Early Detection Research Network funded research which allows for increased collection and analysis of early lesions and indeterminate pulmonary nodules (IPNs) and provides a platform for interventional stuearly detection and molecular oncology, including the creation of the Lung Nodule Clinic, a translational laboratory for early detection and Early Detection Research Network funded research which allows for increased collection and analysis of early lesions and indeterminate pulmonary nodules (IPNs) and provides a platform for interventional stuearly detection and Early Detection Research Network funded research which allows for increased collection and analysis of early lesions and indeterminate pulmonary nodules (IPNs) and provides a platform for interventional stuEarly Detection Research Network funded research which allows for increased collection and analysis of early lesions and indeterminate pulmonary nodules (IPNs) and provides a platform for interventional stuearly lesions and indeterminate pulmonary nodules (IPNs) and provides a platform for interventional studies.

The most clinically desirable biomarkers are those associated with early stage tumor development as they enable surgical removal of lesions before widespread metastasis.

When these Stat5a − / − mice were bred to MMTV - tva mice, infected with RCAS - caErbb2, impregnated 4 days post infection, and analyzed at I10, the resultant early lesions exhibited significantly lower levels of pSTAT5 than did the lesions in Stat5a + / + mice (Figure 5A) confirming the predominance of STAT5a in the mammary gland.

Of note, AG490 did not affect pSTAT1, pSTAT3 or pSTAT6 positivity in either parous or virgin early lesions (Figure 6 — figure supplement 1B).

In addition, in any virgin mouse, some of the early lesions had relatively high percentage of pSTAT5 cells, and they correspondingly showed reduced levels of apoptosis (Figure 4 — figure supplement 2).

Indeed, the inactivated form of GSK3β, pS9 - GSK3β, was readily detected by immunohistochemistry in caErbb2 - initiated early lesions in parous mice while it was not found in normal mammary cells (Figure 3E).

Apoptosis levels were inversely correlated with levels of pSTAT5 in early lesions from these two groups of mice (Figure 4 — figure supplement 2B).

For example, while almost half (about 46 percent) of married patients presented with a very treatable, early stage melanoma lesion, that number fell to 43 percent for patients who'd never married, 39 percent for divorced patients, and 32 percent for widowed patients, the findings showed.

The blood test also was able to detect 77 percent of pre-cancerous lesions indicating early stage disease.

One thing is certain: low - protein diets depressed normal growth, increased the suceptibility to many toxins, killed toxin - exposed animals earlier, induced fatty liver, and increased the development of pre-cancerous lesions when fed during the initiation period of chemical carcinogenesis.

It has been proven that animal protein can literally turn on and off the development of tumors or early lesions that lead to tumors.

Imlygic (talimogene laherparepvec), a first - of - its - kind therapy, showed promise against lesions in the skin and lymph nodes in an early trial, the FDA said Tuesday.

Lipid peroxidation in insulin - dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation.

An annual examination will help determine whether (or when) dental prophylactic cleaning will be needed, and will permit early identification of common, but often painful, cervical neck lesions on teeth.

Conservative treatment may be indicated for dogs that have early mild symptoms of OCD or where a specific lesion can not be identified on radiographs.

When hookworm larvae enter the host cat, they often leave small lesions on the foot pads and between the toes — early symptoms of the disease.

Squamous cell carcinoma can be diagnosed in its earliest stages by a biopsy of the lesion, which can be performed by your veterinarian or veterinary ophthalmologist.

Temperature - sensitive mutants with lesions in the vaccinia virus F10 kinase undergo arrest at the earliest stage of virion morphogenesis.

Magnetic resonance imaging (MRI) and computed tomography (CT) have an increased sensitivity for the diagnosis of discospondylitis and can be useful in revealing early lesions.

Early spaying may therefore, reduce occurrence of malignant lesions because the procedure removes the source of the hormones that cause some mammary cells to lose growth control, which puts these dividing cells at high risk for mutation and malignant transformation by environmental carcinogens.In fact, recent reports have identified activation of a specific oncogene in a number of canine mammary tumors.

«Many cats with severe hypertensive ocular damage present with blindness and bilateral mydriasis resulting from complete retinal detachments and / or intraocular haemorrhage; the changes are often irreversible... Lesions that are not associated with an impaired menace response or pupillary light deficits... are much more amenable to anti-hypertensive treatment... highlighting the importance of early diagnosis and management.

Starting at an early age, you should touch and examine your pet's mouth, looking for abnormal lesions or areas of pain.

The goal is to determine whether diffusion tensor imaging can detect early spine lesions in dogs with symptoms of DM.