Sentences with phrase «early phase clinical»

American Healthcare Investors negotiated the nine - year lease for the tenant, which performs early phase clinical research of drugs and devices for diabetes, obesity, and cardiometabolic diseases in cooperation with the pharmaceutical industry.

As the Director of the Early Phase Clinical Trials Program at Roswell Park, I am responsible for developing novel therapies for many types of cancer, including melanoma.

To further develop genetically directed early phase clinical trials — in part through Center for Cancer Targeted Therapeutics (C2T2), Early Cancer Therapeutics Consortium (ECTC), National Clinical Trials Network (NCTN) with Molecular Analysis for Therapy Choice (MATCH).

The Brain and Spinal Tumor Program at the Kimmel Cancer Center is a member of the Adult Brain Tumor Consortium (ABTC), a group of 16 medical centers dedicated to improving treatments for adults with malignant brain tumors by initiating early phase clinical trials and collaborations with researchers and other clinical trials groups.

CDP is a joint initiative between Cancer Research UK's Drug Development Office and Cancer Research Technology, to progress promising anti-cancer agents which pharmaceutical companies do not have the resources to progress through early phase clinical trials.

The Johns Hopkins Kimmel Cancer Center is one of 11 Lead Academic Organization sites of the National Cancer Institute's Experimental Therapeutics Clinical Trials Network (ETCTN), which supports the evaluation of early phase clinical trials on experimental therapies.

Overall, SR - Tiget represents a multi-disciplinary research environment, which provides a unique blend of scientific expertise in the development of innovative gene and cell therapy strategies, access to relevant preclinical models to evaluate their efficacy and safety, as well as competence in conducting early phase clinical trials.

C2T2 studios bring together a multidisciplinary group of investigators to discuss new ideas for early phase clinical trials.

To address the challenges involved in this process, the C2T2 brings together our early phase clinical trials program, precision cancer medicine initiatives, and non-invasive imaging core.

The drug is ready to be taken into early phase clinical trials.

Research at SR - Tiget spans from basic research to pre-clinical studies to early phase clinical trials according to the following major aims:

The scientific goal of the Developmental Cancer Therapeutics Program is to discover and characterize unique agents and pathways that will impact the development of more effective cancer therapies and to translate these discoveries into clinical applications by using proof - of - principle, early phase clinical and correlative science studies.

The clinical biostatistics team has strong connection with the Biometry department (Head A. Savignoni), the early phase clinical trial and precision medicine unit where patients are treated with drugs in development (Head C. Le Tourneau), the translational research department in particular the Circulating Tumor Biomarkers laboratory (Charlotte Proudhon), and of course the other teams of the U900.

Chief of Melanoma; Director, Early Phase Clinical Trials Program; and Co-Leader, CCSG Experimental Therapeutics Program

So far, JQ1 has been relatively well tolerated in both preclinical studies and in early phase clinical trials for cancer patients.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

Together with the research and clinical resources of the nation's leading cancer hospital, we have the ability to take a program from a research hypothesis all the way to a clinical candidate supported by robust preclinical data, and into early phase clinical studies in well - defined patient populations.

In August 2014, KalVista Pharmaceuticals Ltd. launched an early phase clinical trial of a PKal inhibitor to treat DME, with Jennifer Sun, M.D., Ph.D., of Joslin's Beetham Eye Institute as principal investigator.

In my role as a Clinical Professor of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Professor of Medicine and Director of Early Phase Clinical Trials Program in the Department of Medicine at Roswell Park Comprehensive Cancer Center, I am developing novel therapies for patients with cancer.

He is working closely with a team of physicians at the UNM Cancer Center to conduct these trials: M. Omar Chohan, MD, a neurosurgeon who specializes in surgery for tumors of the brain and spinal cord; Gregory Gan, MD, PhD, a radiation oncologist who is an expert in the radiation therapy of brain tumors; and Yanis Boumber, MD, PhD, a newly recruited medical oncologist to the UNM Cancer Center who is an expert in cancers of the lung, brain and spinal cord, and early phase clinical trials.

While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system for large - scale efficient culture of lymphocytes that has proved to be the foundation for over 35 early phase clinical trials of adoptive immunotherapy.

Early phase clinical trials in Australia are 28 % cheaper than the USA before tax incentives, and 60 % cheaper after tax incentives.

«In an earlier phase I clinical study, our group has shown that increasing the dose of radiation delivered daily with high precision and using image guidance may offset the need for chemotherapy in improving survival, and it may also improve quality of life measures by reducing treatment periods in half.

Not exact matches

WA's only early phase unit, Linear Clinical Research Ltd, which is a wholly owned subsidiary of the Harry Perkins Institute of Medical Research, is contributing to medical breakthroughs via a technologically focused research facility with 37 beds.

Amazingly, if these Phase III companies can secure funding, they typically require less than $ 10 million for early clinical data to prove whether something is worth pursuing.

ACT is now performing early - phase clinical trials testing the safety of implanting retinal cells derived from human ES cells into the eye to treat certain types of blindness.

Investigators now are considering conducting an early - phase clinical trial in which healthy participants would consume a low - asparagine diet.

Promising results of an earlier, initial, multicenter clinical trial of nivolumab, first reported in 2013 and directed by Brahmer, led to the current phase III trial of 260 patients treated at hospitals across the world.

Under the new organizational structure, Genentech Research and Early Development program, dubbed gRED, which essentially comprises basic research up to Phase 2 clinical trials, will maintain its autonomy.

Samuel Weiss, PhD, Professor and Director of the HBI, and Research Assistant Professor Artee Luchman, PhD, and colleagues, published their work today in Clinical Cancer Research, which is leading researchers to start a human phase I / II clinical trial as early as SpriClinical Cancer Research, which is leading researchers to start a human phase I / II clinical trial as early as Spriclinical trial as early as Spring 2015.

White and colleagues will work with other collaborators at the Cancer Institute to develop early - phase patient clinical trials based on the findings from this study in the near future.

«The next step is to figure out how to bring this finding into early - phase clinical trials with patients, and we're partnering with pharmaceutical companies to explore this,» Goga said.

Women in the early phases of menopause are more likely to have trouble sleeping during certain points in the menstrual cycle, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

These results support Afferent's current development strategy to initiate a Phase 2b clinical trial early in 2015.

An advisory panel to the FDA recommended approval of Provenge on the basis of good early clinical results, but the FDA instead requested more information last May after a second phase III clinical trial seemed more equivocal.

While the last decade has seen many potential new agents for hepatocellular carcinoma fail in clinical trials, phase I and II data from early regorafenib trials were promising, and led to the initiation of this international, multi-center phase III trial.

The research, part of a phase I clinical trial to test the safety of the treatment, was published as a letter to the editor in The New England Journal of Medicine earlier this week and will be in the September issue of Human Gene Therapy.

The next phase of the research will see this team, in collaboration with clinical colleagues in the Netherlands, identify early life clinical markers of the future renal and cardiovascular health of these children.

Learn more about how we are delivering on our commitment to leading medicine from the earliest phase of discovery in a lab to the testing new drugs or therapies in clinical trials.

Research Interests: Clinical pharmacology of anticancer agents; early phase drug development; drug tolerability in cancer patients with HIV / AIDS; drug tolerability in cancer patients with organ dysfunction; blood - brain barrier penetration of drugs.

Phase I trial - an early clinical trial designed to study an experimental vaccine in humans.

The targeted antibody bevacizumab (Avastin ®) is already approved for ovarian cancer patients, and a number of immune - based therapies are being investigated in early - phase clinical trials for patients with ovarian cancer.

GenIbet's core activity is the manufacture and supply of materials for use in early stage drug development, pre-clinical studies and cGMP manufacturing from Phase I to Phase III clinical trials.

Andy has over 10 years of experience in clinical trial management, specializing in early phase, first - in - human, global studies.

My translational research interests involve clinical trials evaluating targeted biologic agents, particularly early phase trials with targeted antibodies.

As of early 2012, clinical trials of IL - 17 antibodies against psoriasis have shown promising results in Phase II.

165 patients with early - stage Alzheimer's disease were treated in the phase 1b clinical trial.

Early phase trials with anti-PD-L1 and anti-PD-1 antibodies have shown clinical activity in RCC and early biomarker assessment suggests PD - L1 tumor expression may influence respEarly phase trials with anti-PD-L1 and anti-PD-1 antibodies have shown clinical activity in RCC and early biomarker assessment suggests PD - L1 tumor expression may influence respearly biomarker assessment suggests PD - L1 tumor expression may influence response.

The results of a multi-institutional, phase 3 clinical trial of apalutamide — led by investigators from Massachusetts General Hospital (MGH) and University of California San Francisco (UCSF)-- are receiving early release publication in the New England Journal of Medicine to coincide with a presentation today at the American Society for Clinical Oncology Genitourinary Cancers (ASCO - GU) Syclinical trial of apalutamide — led by investigators from Massachusetts General Hospital (MGH) and University of California San Francisco (UCSF)-- are receiving early release publication in the New England Journal of Medicine to coincide with a presentation today at the American Society for Clinical Oncology Genitourinary Cancers (ASCO - GU) SyClinical Oncology Genitourinary Cancers (ASCO - GU) Symposium.

Phase 1 clinical trials give patients at University of Michigan access to pivotal early - stage studies, connecting families to novel treatment therapies to patients before they are widely available.