So far, JQ1 has been relatively well tolerated in both preclinical studies and in
early phase clinical trials for cancer patients.
Not exact matches
While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system
for large - scale efficient culture of lymphocytes that has proved to be the foundation
for over 35
early phase clinical trials of adoptive immunotherapy.
While the last decade has seen many potential new agents
for hepatocellular carcinoma fail in
clinical trials,
phase I and II data from
early regorafenib
trials were promising, and led to the initiation of this international, multi-center
phase III
trial.
He is working closely with a team of physicians at the UNM Cancer Center to conduct these
trials: M. Omar Chohan, MD, a neurosurgeon who specializes in surgery
for tumors of the brain and spinal cord; Gregory Gan, MD, PhD, a radiation oncologist who is an expert in the radiation therapy of brain tumors; and Yanis Boumber, MD, PhD, a newly recruited medical oncologist to the UNM Cancer Center who is an expert in cancers of the lung, brain and spinal cord, and
early phase clinical trials.
The targeted antibody bevacizumab (Avastin ®) is already approved
for ovarian cancer patients, and a number of immune - based therapies are being investigated in
early -
phase clinical trials for patients with ovarian cancer.
In my role as a
Clinical Professor of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Professor of Medicine and Director of
Early Phase Clinical Trials Program in the Department of Medicine at Roswell Park Comprehensive Cancer Center, I am developing novel therapies
for patients with cancer.
GenIbet's core activity is the manufacture and supply of materials
for use in
early stage drug development, pre-
clinical studies and cGMP manufacturing from
Phase I to
Phase III
clinical trials.
The results of a multi-institutional,
phase 3
clinical trial of apalutamide — led by investigators from Massachusetts General Hospital (MGH) and University of California San Francisco (UCSF)-- are receiving early release publication in the New England Journal of Medicine to coincide with a presentation today at the American Society for Clinical Oncology Genitourinary Cancers (ASCO - GU) Sy
clinical trial of apalutamide — led by investigators from Massachusetts General Hospital (MGH) and University of California San Francisco (UCSF)-- are receiving
early release publication in the New England Journal of Medicine to coincide with a presentation today at the American Society
for Clinical Oncology Genitourinary Cancers (ASCO - GU) Sy
Clinical Oncology Genitourinary Cancers (ASCO - GU) Symposium.
Clinical Trials Research and Billing First in Human /
Early Phase PET in Oncology Case - Based Dose Reduction in Pediatric Nuclear Medicine: Practical and Necessary Radioiodine Therapy
for Hyperthyroidism: The State of the Art Spondylodiscitis: Role of Imaging
for Diagnosis and Monitoring Treatment Response Current Status and Future Prospects: PET and SPECT Instrumentation Alternative Payment Models and Value - Based Health Care: Nuts and Bolts Maximal Tolerated Activity of Radioactive Iodine
for Metastatic Thyroid Cancer Teaching Old Radiopharmaceuticals New Tricks Intraoperative Detection Devices and Probes Molecular Imaging of Lung Inflammation Standardization of Advanced PET / SPECT Data Acquisition and Analysis Thyroid Cancer Management: Novel Therapeutics and Management Options Targeting Radionuclide Therapy in Various Non-Malignant Arthritic Conditions Using Radiosynoviorthesis (RSO) Are You Prepared
for a Radiation Accident?
C2T2 studios bring together a multidisciplinary group of investigators to discuss new ideas
for early phase clinical trials.
Phase 1
clinical trials are used in patients
for whom conventional treatment has not worked, providing access to pivotal first - in - children,
early - stage
clinical trials with novel treatments before they are widely available.
The Center
for Cancer Targeted Therapies (C2T2) integrates a
phase I - Ib /
early clinical trials program, a precision cancer medicine infrastructure with expertise on tumor tissue - based state - of - the - art molecular methods, and a core resource with novel non-invasive functional imaging methods.
The Brain and Spinal Tumor Program at the Kimmel Cancer Center is a member of the Adult Brain Tumor Consortium (ABTC), a group of 16 medical centers dedicated to improving treatments
for adults with malignant brain tumors by initiating
early phase clinical trials and collaborations with researchers and other
clinical trials groups.
To further develop genetically directed
early phase clinical trials — in part through Center for Cancer Targeted Therapeutics (C2T2), Early Cancer Therapeutics Consortium (ECTC), National Clinical Trials Network (NCTN) with Molecular Analysis for Therapy Choice (MA
early phase clinical trials — in part through Center for Cancer Targeted Therapeutics (C2T2), Early Cancer Therapeutics Consortium (ECTC), National Clinical Trials Network (NCTN) with Molecular Analysis for Therapy Choice
clinical trials — in part through Center for Cancer Targeted Therapeutics (C2T2), Early Cancer Therapeutics Consortium (ECTC), National Clinical Trials Network (NCTN) with Molecular Analysis for Therapy Choice (M
trials — in part through Center
for Cancer Targeted Therapeutics (C2T2),
Early Cancer Therapeutics Consortium (ECTC), National Clinical Trials Network (NCTN) with Molecular Analysis for Therapy Choice (MA
Early Cancer Therapeutics Consortium (ECTC), National
Clinical Trials Network (NCTN) with Molecular Analysis for Therapy Choice
Clinical Trials Network (NCTN) with Molecular Analysis for Therapy Choice (M
Trials Network (NCTN) with Molecular Analysis
for Therapy Choice (MATCH).
As the Director of the
Early Phase Clinical Trials Program at Roswell Park, I am responsible
for developing novel therapies
for many types of cancer, including melanoma.