Sentences with phrase «early phase clinical trials of»

While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system for large - scale efficient culture of lymphocytes that has proved to be the foundation for over 35 early phase clinical trials of adoptive immunotherapy.

In August 2014, KalVista Pharmaceuticals Ltd. launched an early phase clinical trial of a PKal inhibitor to treat DME, with Jennifer Sun, M.D., Ph.D., of Joslin's Beetham Eye Institute as principal investigator.

Not exact matches

ACT is now performing early - phase clinical trials testing the safety of implanting retinal cells derived from human ES cells into the eye to treat certain types of blindness.

Promising results of an earlier, initial, multicenter clinical trial of nivolumab, first reported in 2013 and directed by Brahmer, led to the current phase III trial of 260 patients treated at hospitals across the world.

Samuel Weiss, PhD, Professor and Director of the HBI, and Research Assistant Professor Artee Luchman, PhD, and colleagues, published their work today in Clinical Cancer Research, which is leading researchers to start a human phase I / II clinical trial as early as SpriClinical Cancer Research, which is leading researchers to start a human phase I / II clinical trial as early as Spriclinical trial as early as Spring 2015.

An advisory panel to the FDA recommended approval of Provenge on the basis of good early clinical results, but the FDA instead requested more information last May after a second phase III clinical trial seemed more equivocal.

While the last decade has seen many potential new agents for hepatocellular carcinoma fail in clinical trials, phase I and II data from early regorafenib trials were promising, and led to the initiation of this international, multi-center phase III trial.

He is working closely with a team of physicians at the UNM Cancer Center to conduct these trials: M. Omar Chohan, MD, a neurosurgeon who specializes in surgery for tumors of the brain and spinal cord; Gregory Gan, MD, PhD, a radiation oncologist who is an expert in the radiation therapy of brain tumors; and Yanis Boumber, MD, PhD, a newly recruited medical oncologist to the UNM Cancer Center who is an expert in cancers of the lung, brain and spinal cord, and early phase clinical trials.

The research, part of a phase I clinical trial to test the safety of the treatment, was published as a letter to the editor in The New England Journal of Medicine earlier this week and will be in the September issue of Human Gene Therapy.

Learn more about how we are delivering on our commitment to leading medicine from the earliest phase of discovery in a lab to the testing new drugs or therapies in clinical trials.

The targeted antibody bevacizumab (Avastin ®) is already approved for ovarian cancer patients, and a number of immune - based therapies are being investigated in early - phase clinical trials for patients with ovarian cancer.

In my role as a Clinical Professor of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Professor of Medicine and Director of Early Phase Clinical Trials Program in the Department of Medicine at Roswell Park Comprehensive Cancer Center, I am developing novel therapies for patients with cancer.

GenIbet's core activity is the manufacture and supply of materials for use in early stage drug development, pre-clinical studies and cGMP manufacturing from Phase I to Phase III clinical trials.

Andy has over 10 years of experience in clinical trial management, specializing in early phase, first - in - human, global studies.

As of early 2012, clinical trials of IL - 17 antibodies against psoriasis have shown promising results in Phase II.

The results of a multi-institutional, phase 3 clinical trial of apalutamide — led by investigators from Massachusetts General Hospital (MGH) and University of California San Francisco (UCSF)-- are receiving early release publication in the New England Journal of Medicine to coincide with a presentation today at the American Society for Clinical Oncology Genitourinary Cancers (ASCO - GU) Syclinical trial of apalutamide — led by investigators from Massachusetts General Hospital (MGH) and University of California San Francisco (UCSF)-- are receiving early release publication in the New England Journal of Medicine to coincide with a presentation today at the American Society for Clinical Oncology Genitourinary Cancers (ASCO - GU) SyClinical Oncology Genitourinary Cancers (ASCO - GU) Symposium.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

Phase 1 clinical trials give patients at University of Michigan access to pivotal early - stage studies, connecting families to novel treatment therapies to patients before they are widely available.

The drug was approved based on efficacy and safety results from a phase III trial presented earlier this year at the 2015 American Society of Clinical Oncology Annual Meeting.

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Chief of Melanoma; Director, Early Phase Clinical Trials Program; and Co-Leader, CCSG Experimental Therapeutics Program

«This drug has already made it through all of that early toxicity testing,» said Dr. Strange, «and it's also been in what are called FDA Phase 1a and 1b clinical trials.

Texas Children's Cancer Center is a member of the COG Phase I Consortium, a small and select group of institutions that administer Phase I clinical trials of drugs in early development.

The clinical biostatistics team has strong connection with the Biometry department (Head A. Savignoni), the early phase clinical trial and precision medicine unit where patients are treated with drugs in development (Head C. Le Tourneau), the translational research department in particular the Circulating Tumor Biomarkers laboratory (Charlotte Proudhon), and of course the other teams of the U900.

C2T2 studios bring together a multidisciplinary group of investigators to discuss new ideas for early phase clinical trials.

Overall, SR - Tiget represents a multi-disciplinary research environment, which provides a unique blend of scientific expertise in the development of innovative gene and cell therapy strategies, access to relevant preclinical models to evaluate their efficacy and safety, as well as competence in conducting early phase clinical trials.

The Johns Hopkins Kimmel Cancer Center is one of 11 Lead Academic Organization sites of the National Cancer Institute's Experimental Therapeutics Clinical Trials Network (ETCTN), which supports the evaluation of early phase clinical trials on experimental thClinical Trials Network (ETCTN), which supports the evaluation of early phase clinical trials on experimental therTrials Network (ETCTN), which supports the evaluation of early phase clinical trials on experimental thclinical trials on experimental thertrials on experimental therapies.

A combination of complementary immunotherapy drugs brentuximab vedotin (Adcetris ®) and nivolumab (Opdivo ®) destroyed most cancer cells in 64 percent of patients with recurrent Hodgkin lymphoma, according to the results of an early - phase clinical trial led by Catherine M. Diefenbach, MD, assistant professor of medicine and director of the Clinical Lymphoma clinical trial led by Catherine M. Diefenbach, MD, assistant professor of medicine and director of the Clinical Lymphoma Clinical Lymphoma Program.

Promising animal studies of this method of delivering anticancer drugs, known as intraductal chemotherapy, has led to Phase I clinical trials in women with very early breast cancer.

The Center for Cancer Targeted Therapies (C2T2) integrates a phase I - Ib / early clinical trials program, a precision cancer medicine infrastructure with expertise on tumor tissue - based state - of - the - art molecular methods, and a core resource with novel non-invasive functional imaging methods.

Thanks to an experimental drug from Isis Pharmaceuticals that Vivienne received six weeks earlier as part of a phase 1 clinical trial, her parents now say she has more strength, more poise and more self - assurance.

The Brain and Spinal Tumor Program at the Kimmel Cancer Center is a member of the Adult Brain Tumor Consortium (ABTC), a group of 16 medical centers dedicated to improving treatments for adults with malignant brain tumors by initiating early phase clinical trials and collaborations with researchers and other clinical trials groups.

As the Director of the Early Phase Clinical Trials Program at Roswell Park, I am responsible for developing novel therapies for many types of cancer, including melanoma.