Sentences with phrase «early progression in»
A reduced number of chemotherapy cycles (n = 1 — 5) were delivered to the remaining 24 patients due to poor performance status in 6, toxicity in 9 and early progression in 8 patients.
http://www.haematologica.org/ Not exact matches
Precision medicine is the «cure» piece, but even that isn't possible if we don't move the intervention curve closer and accurately predict and prevent early enough in the progression of disease.»
It also places it in continuity with the experiences of the early church, and within the continuing narrative of the development of Christian thought — as people have struggled to make sense of and articulate their lived experience of God — which produced the great ecumenical creeds (with their clear progression of understanding about God, Christ and the Holy Spirit)- and which continues on today.
Perhaps atheism isn't the hero of liberation the artist intends to convey, but it is true that religion tends to bind the mind and hinder the natural progression and development of cognition and reason, especially when one was indoctrinated in it at a very early age.
Well attitude can hinder progression is a fact but from what I've watched Chris is better and is more rated than his brother in Arsenal.Also attitude can change so there's still more hope.There a lot of players with bad attitude even in their early years but are still making it big.As for Bendtner having that talent well every one is entitled to his opinion.
As a striker Nsue had pace and skills to dazzle opposing defenders and an early goalscoring record that suggested a bright future at the head of Mallorca's formation, but his progression failed to materialise in the way many expected.
He could have gone on to say that in the early 2000s, Conservative councils were anything but covert in their open destruction of the party's free schools policy, which was a logical progression of the grant - maintained concept and a flagship policy of then leader William Hague and (before there are cries of «lurch to the right!»)
Progression in the party's polling was heightened from the early 1920s when the seat joined many wrested from the Liberal Party, enabling the formation of the first Labour government.
«This novel technique,» they said, «should help distinguish and monitor cancer stages and progression, aid in elucidation of basic mechanisms underlying tumorigenesis, and facilitate analyses of processes related to early detection of cancer, screening and / or cancer risk assessment.»
They also believe that by measuring a patient's dark adaptation response time they have developed a tool that can help track the onset or progression of the disease as well as measure the effectiveness of drugs that are in development to treat the disease early on.
«Moving to non-invasive and repeatable methods of nerve fiber measurements such as in vivo corneal confocal microscopy would enhance study of peripheral neuropathy by enabling early detection of damage, progression of nerve fiber deterioration, and enable assessment of therapeutic strategies in the SIV / macaque model,» explains Dr. Mankowski.
«Now that we have more evidence that serotonin is a chemical that appears affected early in cognitive decline, we suspect that increasing serotonin function in the brain could prevent memory loss from getting worse and slow disease progression,» says Gwenn Smith, Ph.D., professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine and director of geriatric psychiatry and neuropsychiatry at Johns Hopkins University School of Medicine.
Johns Hopkins physicians report success in a small study of a modified skin biopsy that hastens the earlier diagnosis of an inherited and progressively fatal nerve disease and seems to offer a clearer view of the disorder's severity and progression.
«With early diagnosis, appropriate treatments can be conducted in time and sepsis progression can be controlled,» Zhang said.
Redfield has a long history of publishing reports about his work: In 1988 he co-wrote a Scientific American feature article about early HIV research (available via subscription only), which emphasized the importance of studying the progression of HIV into AIDS, and of diagnosing the viral disease as early as possible.
Early diagnosis and therapy has been identified as a potentially crucial step in achieving optimal control of disease progression and prognosis in RA.
Findings indicate Alzheimer's starts in early childhood, and the disease progression relates to age, APOE 4 status and particulate exposure.
«Although still only in an early phase trial, brigatinib is showing an objective response rate in approximately 70 percent of ALK - positive patients post-crizotinib and it's showing about a year of progression - free survival.
A test for the early stages of the condition would be helpful in efforts to develop drugs that can slow its progression.
«It's early to speculate,» Kipnis says, «but I think that alteration in these vessels may affect disease progression in those neurological disorders with a prominent immune component, such as multiple sclerosis, autism and Alzheimer's disease.»
Ben Stanger, MD, PhD, a professor in the division of Gastroenterology, and first author Ravi Maddipati, MD, an instructor in the division of Gastroenterology, say that these results may prove useful in designing better targeted therapies to stop tumor progression and provide an improved non-invasive method for detecting early disease states in this highly lethal cancer.
The authors speculate the reasons for the prolonged survival in their study is that patients with MGUS are evaluated more often for signs of progression to MM and may be diagnosed and started on therapy for myeloma at an earlier stage.
They write, «Those patients with retained orbits, orbital nerve function, and early vision changes should be considered optimal candidates for allotransplantation in an effort to reverse the progression to blindness.»
The cause of early metastatic relapse in breast cancer has long been debated, with many ascribing these relapses to the natural progression of the disease.
Based on nationwide monitoring data, the study «offers valuable insight into the early identification of ASD and suggests some progression towards lowering the age of first evaluation in participating communities,» write Dr. Daisy Christensen of the National Center on Birth Defects and Developmental Disabilities and colleagues.
«The probe may potentially be useful to monitor patient's response to medication,» said Associate Professor Louis Tan, Senior Consultant, Department of Neurology at the National Neuroscience Institute, whose team has recently shown in a separate study that long term use of a MAO - B inhibitor reduces the progression of early Parkinson's disease.
In the study of people with early ADPKD and healthy kidneys, researchers also tested if decreasing blood pressure below usual targets would slow progression of ADPKD and preserve kidney function.
Earlier studies suggested the possible involvement of these support cells in ALS development and progression, but the new research is believed to be the first to directly measure the effects of aging on the ability of astrocytes to sustain motor neurons.
The biomarkers also point to other underlying mechanisms that contribute to the progression of CF and could lead to better therapeutic interventions earlier in life.
It is our hope that defining this link between central corneal thickness and glaucoma will aid in early detection of glaucoma and eventually treatments to halt the progression of this disease.»
It is difficult to detect the early onset of the disease and if undetected or misdiagnosed has a rapid rate of progression in the first few years.
«Historically, when treating early lung cancer with radiotherapy, progression at the site of the primary tumor was the most common failure resulting in suffering and death,» said lead study author Robert Timmerman, MD, professor and vice chair of the department of radiation oncology at the University of Texas Southwestern Medical Center in Dallas.
Scientists have found that miRNAs regulate early development, for example, and may play a role in cancer progression.
Studying these symptoms earlier in the animal model gives researchers more time to monitor the progression of the disease as well as assess the efficacy of potential therapeutics and to determine if and when the course of the disease could be altered.
«What we see is an association between shorter periods of progression - free survival and overall survival in patients whose blood has higher levels of hypermethylated DNA, and we can see this very early on, after just four weeks of treatment,» says Sara Sukumar, Ph.D., professor of oncology at the Johns Hopkins University School of Medicine and member of the Kimmel Cancer Center, who developed the test with Johns Hopkins scientist Mary Jo Fackler, Ph.D., and others.
«We could reduce the dependency on intravitreal injections and perhaps consider treating patients earlier in the progression of the disease.»
Christophe Benoist, M.D., professor of Microbiology and Immunobiology at Harvard Medical School, (who spoke on behalf of Diane Mathis, Ph.D., also a professor in the same department) discussed a molecule called I - BET that, when used as a treatment in animals during pre-diabetes or in the early stages of clinical type 1 diabetes, seemed to slow the progression of the disease.
Levels of a small non-coding RNA molecule called let - 7 appear to define different stages of cancer better than some of the «classical» markers for tumor progression, researchers from the University of Chicago report in the June 25, 2007, early online edition of the Proceedings of the National Academy of Sciences.
Early studies provided the initial correlative suggestion that loss of alpha2 beta1 integrin expression might play an important role in cancer progression.
They found that early phenformin treatment causes increased survival and slower tumor progression in tumors lacking LKB1, but had no significant benefit for tumors with alterations in other lung cancer genes.
And we are now taking advantage of the different skills that we have in the consortium to try to interpret these and see how they evaluate the potential to be a biomarker of either progression or an early diagnostic tool.
Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.
These biomarkers can then be applied in glaucoma suspects or glaucoma patients to detect disease earlier as well as to detect progression much earlier at a stage where it can be prevented through appropriate treatments.
Scientists at Helmholtz Zentrum München have discovered a mechanism that amplifies the autoimmune reaction in an early stage of pancreatic islet autoimmunity prior to the progression to clinical type 1 diabetes.
Early Intervention with an Estrogen Receptor β - Selective Phytoestrogenic Formulation Prolongs Survival, Improves Spatial Recognition Memory, and Slows Progression of Amyloid Pathology in a Female Mouse Model of Alzheimer's Disease.
In early stages of HIV infection, HIV predominantly uses the CCR5 co-receptor, whereas during the disease progression HIV uses either CXCR4 alone or in combination with CCR5 in about 50 % of the infected individuals [18, 19In early stages of HIV infection, HIV predominantly uses the CCR5 co-receptor, whereas during the disease progression HIV uses either CXCR4 alone or in combination with CCR5 in about 50 % of the infected individuals [18, 19in combination with CCR5 in about 50 % of the infected individuals [18, 19in about 50 % of the infected individuals [18, 19].
Maybe there won't be a cure, or even a reversal once major damage is done, but the possibility remains that if the disease could be identified much earlier, when its effects are still minor, drugs now in the testing phase might be able to halt the disease's progression.
Early disease progression for chronic lymphocytic leukemia was a robust prognostic factor for worse overall survival in patients treated with chemoimmunotherapy.
They are seeking ways to target the disease at its earliest stages, so that innovative treatments might be developed to significantly delay disease progression even in patients who do not respond to current medical and surgical treatments that only lower pressure in the eye.
The current project utilized an array of immunochemical and molecular tools to perform a characterization of retinal pathology in the early stages of disease progression using a well - validated mouse model of AD (APPSWE / PS1ΔE 9).