Sentences with phrase «early stage clinical»

Most recently, CRI has launched a new «venture philanthropy» program called the Cancer Vaccine Acceleration Fund (CVAF) as a means to catalyze development of next - generation therapeutic cancer vaccines and other immunotherapies by helping to address the critical shortage of capital available for early stage clinical trials.

A malaria vaccine has shown promising results in early stage clinical trials, a study suggests.

Several early stage clinical trials using autologous infusions of ZFN - generated CCR5 - modified CD4 + T cells are currently underway (clinicaltrials.gov identifiers NCT00842634, NCT01252641, NCT01044654).

The new drug will now be tested in patients with chronic lymphocytic leukemia and non-Hodgkin lymphoma in an early stage clinical trial.

An early stage clinical trial in humans, run by firm NoNO in Ontario has also seen positive results.

Established by AllerGen in 2005, the Clinical Investigator Collaborative is globally unique in its ability to undertake early stage clinical trials to evaluate the efficacy of new molecules and compounds that treat inflammation in the lung.

Not exact matches

BioNTech hit the headlines in July when its experimental personalized cancer vaccine, tailored to the tumors of individual patients, kept disease in check in an early - stage clinical trial.

Clinical experience has made it clear to me that there are several different Child sides from different stages of our early lives.

These included clinical assessment skills in the antenatal period, documentation of instructions given to clients to ensure that midwives could arrive at the birth in a timely fashion, early transport after identification of thick meconium in the amniotic fluid and active management of the third stage of labour for women at risk for postpartum hemorrhage.11

«More people need to be tested at an early stage, without clinical symptoms,» says Papa Salif Sow, who helps oversee Gilead's efforts to improve access to treatments in Africa.

He cautions, however, about drawing too many conclusions from animal studies and early - stage clinical trials.

The researchers gave cefoperazone, a commonly - used antibiotic, to mouse mothers in the late stages of pregnancy through the period that they nursed their pups, i.e. to mimic a common clinical scenario of early antibiotic exposure in humans.

«We also know from Novartis» early - stage clinical trials that the drug exhibits few documented side effects in people.»

Results from this early - stage clinical trial have not yet been published or reported at medical meetings.

The finding suggests that treatment strategies for Huntington's that aim to shut off the huntingtin gene in adults — now in early clinical stages — could be safe.

The neuroprotective effects of nicotine were studied in a randomized clinical trial involving 67 subjects in the early stages of Alzheimer's disease, where memory was slightly impaired but decision - making and other cognitive abilities remained intact.

Professor Arnie Purushotham, Cancer Research UK's senior clinical adviser, said: «One of the challenges when treating early stage breast cancer is trying to minimise the side effects that can have a real impact on a woman's life, without affecting the chances of curing her.

As Scientific American reported earlier this year, more than half of the current cancer clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the early stages of understanding how to use such treatment on a larger scale.

Chlorotoxin's performance through the early stages of clinical trials has not gone unnoticed.

HB 661 would permit people with chronic illness to get therapies in early - stage clinical trials — not just terminally ill patients, as the state's current «right - to - try» law does.

An early - stage clinical study by another institution, published in the Lancet Oncology in May 2016, combined chemotherapy with an experimental drug that blocks CCR2, a receptor on monocytes and macrophages whose activation stimulates these cells to infiltrate tumors.

With the initial contract of $ 24.9 million over the next 18 months, Mapp Pharmaceutical will manufacture a small amount of the drug for early - stage clinical studies to demonstrate its safety and efficacy in people.

Clinical trials should be performed to evaluate if postoperative chemotherapy would benefit these patients who typically may not receive chemotherapy because of their early stage.»

«Early identification of patients more likely to experience end - stage kidney disease is an urgent, unmet clinical need,» Kretzler says.

An experimental vaccine to prevent the mosquito - borne viral illness chikungunya elicited neutralizing antibodies in all 25 adult volunteers who participated in a recent early - stage clinical trial conducted by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

In current clinical practice, no biomarkers exist for diagnosing early - stage disease.

So now, with late - stage clinical failures piling up, the U.S. Food and Drug Administration (FDA) has set off down a path to adapt those standards as researchers are pushed inexorably into earlier and earlier forms of the disease, ahead of the brain damage inflicted by Alzheimer's.

Future refinements should sharpen the method's ability to accurately identify Alzheimer's disease at an early stage — prior to the onset of clinical symptoms — in a primary care setting, with just a simple blood extraction.

Dr. Sparano continued: «This is the first prospectively conducted clinical trial evaluating this assay — or any multigene expression assay for that matter — in which patients with early stage breast cancer were uniformly treated based on their assay results.

The findings provide the highest level of evidence supporting expert - derived clinical practice guidelines which have recommended Oncotype DX in patients with early stage ER - positive breast cancer.

«The compelling results seen in this global study provide unequivocal evidence supporting the clinical utility of Oncotype DX to risk - stratify patients with early stage breast cancer, and indicate that the findings are generalizable to everyday clinical practice,» said lead author Joseph A. Sparano, MD, vice-chairman of medical oncology at Montefiore Einstein Center for Cancer Care, and professor of medicine and of obstetrics, gynecology, women's health at Albert Einstein College of Medicine.

They are hugely important in the early stages of drug testing, before clinical trials in humans can begin.

In the 1980s, both US - based and international randomized clinical studies found that BCT and mastectomy offered women with early stage breast cancer equal survival benefit.

«The good news is that this finding predicts that patients missing either gene should be sensitive to new therapies targeting focal adhesion enzymes, which are currently being tested in early - stage clinical trials,» says Shaw, who is also a member of the Moores Cancer Center and an adjunct professor at the University of California, San Diego.

A 2010 study by William Jarrold, a cognitive scientist at the University of California, Davis, suggests that an automated system that analyzes speech patterns on phone calls can potentially pick up on cognitive impairment and clinical depression or determine if someone is in the very early stages of Alzheimer's.

Results released earlier this year from a clinical trial in mid - to late - stage Alzheimer's patients were «a bit of a mixed bag,» says Hale.

But this is early laboratory research and the next stage is for clinical trials to confirm whether resveratrol has the same effects in people at high risk of bowel cancer.»

Liu, a faculty member in both bioengineering and mechanical engineering at Lehigh University, is in the early stages of testing his device in a clinical setting — and the results are promising.

AKI is largely asymptomatic, lacking warning signs such as pain, shortness of breath or other clinical symptoms, particularly in the early stages when intervention is most beneficial.

An initial clinical trial of simvastatin in people with early - stage MS showed reductions in brain lesions, suggesting an effect on the underlying disease process.

BWF Clinical Scientist Awards in Translational Research provide $ 750,000 over 5 years to faculty members in the late - assistant - professor or early - associate - professor stages of their careers.

In the trial, co-led by Rachael Clark, MD, PhD, associate professor of Dermatology at Harvard Medical School, Alain Rook, MD, professor of Dermatology and director of the Cutaneous Lymphoma Program at Penn Medicine, and Joel M. Gelfand, MD, MSCE, associate professor of Dermatology and medical director of the Clinical Studies Unit at Penn Medicine, twelve patients who had previously undergone an average of six treatments for early stage CTCL were treated with topical resiquimod gel at varying doses and intervals.

Clinical trials have yielded some drugs which may be of help in the early stages of Alzheimer's disease.

These data fit perfectly with the preclinical scheme of RA where an external event occurs at an early stage to promote emergence of so - called auto - immunity, followed years later by clinical RA,» she concluded.

They also point to the need for additional research on the earliest stages of AMD,» said Maryann Redford, D.D.S., M.P.H., a program director for Collaborative Clinical Research at NIH's National Eye Institute.

FAK inhibitors are being tested on their own in early stage cancer clinical trials, but it will be some years before it is known if combining these drugs with BRAF inhibitors could help patients.

Sperling is now enrolling people whose brain scans show they might be in the very early stages of Alzheimer's in a clinical trial to test an experimental drug treatment.

Adult mice don't need the gene that, when mutated in humans, causes the inherited neurodegenerative disorder Huntington's disease. The finding suggests that treatment strategies for Huntington's that aim to shut off the huntingtin gene in adults — now in early clinical stages — could be safe.

A major theme is translational research involving the rapid early - stage development and assessment of new vaccines in clinical trials.

In an article published in the Journal of Clinical Oncology (https://doi.org/10.1200/JCO.2017.74.6586), Laenkholm et al report on a study of 2,558 postmenopausal women identified as having HR positive / HER2 - negative, early - stage breast cancer, 1,395 of whom had one to three positive axillary nodes.