Sentences with phrase «early stage trials»

«This is an early stage trial, but we are encouraged by the fact that the cells got into the brain, proliferated, and reduced the level of antigen with very little toxicity to the patients,» O'Rourke said.

The Chicago team has already formed a company, called Coordination Pharmaceuticals, which has raised seed funds to launch an early stage trial in humans, likely sometime in the second half of this year.

Not exact matches

Chief Executive Tom Blomfield recently told CNBCthat the company is in the early stages of talks to expand to the U.S. Revolut recently launched a trial in America.

Still, more drugs are in late - stage trials that could have an impact on the disease, and researchers are pinning hopes on diagnosing the disease early, before symptoms even show up.

And while early results have been promising, some skeptics have held out on the hype due to concerns over side effects and whether results will persist in later - stage trials.

BioNTech hit the headlines in July when its experimental personalized cancer vaccine, tailored to the tumors of individual patients, kept disease in check in an early - stage clinical trial.

Social Capital kicked off a trial of Carroll's model last year with a referral program of sorts — the fund asked other venture capital firms to direct promising early - stage companies to apply through the system.

Although Anavex Life Sciences» Alzheimer's disease program should offer up plenty of data to digest this year, its research program is very early stage, and the company's balance sheet is worrisome enough for me to avoid it until placebo - controlled trial results are available.

While she alluded to the speedy - trial issue in an interview with the Troy Record, for now, Donnelly seems somewhat loath to critique her prospective opponent in detail, at least at this early stage of the campaign.

He cautions, however, about drawing too many conclusions from animal studies and early - stage clinical trials.

«We also know from Novartis» early - stage clinical trials that the drug exhibits few documented side effects in people.»

Results from this early - stage clinical trial have not yet been published or reported at medical meetings.

The trial has also included 10 HER -2-negative breast cancer patients, all of them in early stages of the disease.

Much of my team's work focuses on transgene technology from early - stage experiments in model plants all the way to field trials with crop plants such as corn.

Colleagues from the USA1 carried out a trial in which 83 patients with early stage HNSCC who were all scheduled to undergo neck dissection were injected with the novel tracer, tilmanocept.

The neuroprotective effects of nicotine were studied in a randomized clinical trial involving 67 subjects in the early stages of Alzheimer's disease, where memory was slightly impaired but decision - making and other cognitive abilities remained intact.

While recent human trials have shown tantalizing promise, they're still at an early stage.

As well as revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain disease.

As Scientific American reported earlier this year, more than half of the current cancer clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the early stages of understanding how to use such treatment on a larger scale.

The team is now planning a larger trial in people who have earlier stages of the disease.

Professor Michael Seckl, lead author from the Department of Surgery and Cancer at Imperial said: «Although these are very early - stage results, and are yet to be applied to patients in trials, they suggest the addition of a very cheap diuretic may extend the amount of time we can use the cancer drug erlotinib.

Mesoblast's earlier - stage trials, published in 2015 in Circulation Research, found that patients who received injections of its cell mixture had no further problems related to heart failure.

The results of the early - stage vaccine trial suggest that the preventive treatment should be developed further and that scientists are a step closer to being able to counter a potential H7N9 flu pandemic using a clinically tested vaccine, researchers argue April 30 in Science...

Chlorotoxin's performance through the early stages of clinical trials has not gone unnoticed.

HB 661 would permit people with chronic illness to get therapies in early - stage clinical trials — not just terminally ill patients, as the state's current «right - to - try» law does.

The company also tested the virus in a 23 - person, early - stage trial against colorectal, lung, ovarian and skin cancers.

Promising early - stage trial results led to ponatinib's application being fast - tracked, and it was approved in December 2012.

Clinical trials should be performed to evaluate if postoperative chemotherapy would benefit these patients who typically may not receive chemotherapy because of their early stage.»

An experimental vaccine to prevent the mosquito - borne viral illness chikungunya elicited neutralizing antibodies in all 25 adult volunteers who participated in a recent early - stage clinical trial conducted by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Dr. Sparano continued: «This is the first prospectively conducted clinical trial evaluating this assay — or any multigene expression assay for that matter — in which patients with early stage breast cancer were uniformly treated based on their assay results.

«The promising safety results of these early trials set the stage for additional HCQ trials in different cancers, and trials involving new autophagy inhibitors that are being developed by pharmaceutical companies,» said Amaravadi.

Initial results were announced from the Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, a multi-center prospectively conducted trial of more than 10,000 women with early stage breast cancer sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and led by the ECOG - ACRIN Cancer Research Group (ECOG - ACRIN) with support from Genomic Health, Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, a multi-center prospectively conducted trial of more than 10,000 women with early stage breast cancer sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and led by the ECOG - ACRIN Cancer Research Group (ECOG - ACRIN) with support from Genomic Health, trial of more than 10,000 women with early stage breast cancer sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and led by the ECOG - ACRIN Cancer Research Group (ECOG - ACRIN) with support from Genomic Health, Inc..

They are hugely important in the early stages of drug testing, before clinical trials in humans can begin.

«The good news is that this finding predicts that patients missing either gene should be sensitive to new therapies targeting focal adhesion enzymes, which are currently being tested in early - stage clinical trials,» says Shaw, who is also a member of the Moores Cancer Center and an adjunct professor at the University of California, San Diego.

Results released earlier this year from a clinical trial in mid - to late - stage Alzheimer's patients were «a bit of a mixed bag,» says Hale.

Later this year early - stage human trials will begin for the drug, a collaboration of CSHL and clinicians at the Monter Cancer Center of North Shore - Long Island Jewish Hospital.

When people with early - stage symptoms took omega - 3 supplements for three months, they had much lower rates of progression than those who did not, according to one small - scale trial.

High - intensity exercise three times a week is safe for individuals with early - stage Parkinson's disease and decreases worsening of motor symptoms, according to a new phase 2, multi-site trial led by Northwestern Medicine and University of Denver scientists.

But this is early laboratory research and the next stage is for clinical trials to confirm whether resveratrol has the same effects in people at high risk of bowel cancer.»

Established by AllerGen in 2005, the Clinical Investigator Collaborative is globally unique in its ability to undertake early stage clinical trials to evaluate the efficacy of new molecules and compounds that treat inflammation in the lung.

An initial clinical trial of simvastatin in people with early - stage MS showed reductions in brain lesions, suggesting an effect on the underlying disease process.

In the trial, co-led by Rachael Clark, MD, PhD, associate professor of Dermatology at Harvard Medical School, Alain Rook, MD, professor of Dermatology and director of the Cutaneous Lymphoma Program at Penn Medicine, and Joel M. Gelfand, MD, MSCE, associate professor of Dermatology and medical director of the Clinical Studies Unit at Penn Medicine, twelve patients who had previously undergone an average of six treatments for early stage CTCL were treated with topical resiquimod gel at varying doses and intervals.

An early stage clinical trial in humans, run by firm NoNO in Ontario has also seen positive results.

The new drug will now be tested in patients with chronic lymphocytic leukemia and non-Hodgkin lymphoma in an early stage clinical trial.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

Based on the study published, a larger randomized trial is underway in Tanzania to determine if DAR - 901 prevents the earliest stage of infection with tuberculosis, before symptoms are apparent.

Clinical trials have yielded some drugs which may be of help in the early stages of Alzheimer's disease.

In early - stage premenopausal breast cancer, for example, 10 - year survival rates were 68 % for African Americans versus 77 % for all other patients (mostly Caucasian) in the trials.

Several early stage clinical trials using autologous infusions of ZFN - generated CCR5 - modified CD4 + T cells are currently underway (clinicaltrials.gov identifiers NCT00842634, NCT01252641, NCT01044654).

FAK inhibitors are being tested on their own in early stage cancer clinical trials, but it will be some years before it is known if combining these drugs with BRAF inhibitors could help patients.