Sentences with phrase «early stages of drug»

Debora Konz Makino, Lab Head at CRELUX / WuXi AppTec, explains:» Our long - standing collaboration with ESRF has greatly contributed to the success of most of our client's projects in the early stages of drug discovery.

In the early stages of drug development, new compounds are tested on cell cultures, with the cells» responses closely monitored.

And, to some extent, pharmaceutical companies are already moving in the direction proposed by Bountra, explicitly outsourcing more and more of the early stages of drug discovery.

They are hugely important in the early stages of drug testing, before clinical trials in humans can begin.

Furthermore, the shifts in the industry may herald a new, more fluid division of labor where nontraditional partnerships take on the earliest stages of drug development.

But while LDDN focuses on the earliest stages of drug development — identifying compounds and confirming their biological activity — PharmaStart may take the process much further before signing on with a drug company.

«Although the drug target - selection guidelines that we suggest can not replace expensive experiments, they can help at the earliest stage of a drug - development project.»

Not exact matches

Darzalex, however, has not yet reached its peak potential as the drug moves into earlier stages of the disease and is being tested on solid tumours like lung cancer.

Are you worried about the future of new drug creation, given the relative lack of early - stage pharma investing?

However, industry insiders and market participants warn of risks in the sector, saying that many biotechs are reliant on a handful of early - stage new drugs, making them vulnerable if one fails.

The main focus of acquisitions will be early - stage assets that can add to the pipeline of experimental drugs, Walmsley said, adding she was not interested in entering a $ 64 billion bidding war with Takeda Pharmaceutical for Shire.

That's a big deal because Alnylam's drug is based on an extremely early - stage kind of medical technology called RNAi, or RNA interference, which uses basic biological building blocks to tackle problematic genetic discrepancies.

COPENHAGEN, April 10 Genmab plans to own a bigger share of drugs in its early - stage pipeline as Europe's biggest biotechnology company prepares to reduce its reliance on a blockbuster cancer drug, marketed by partner Johnson & Johnson.

MaRS Innovation (MI) and the Centre for Drug Research and Development (CDRD) are pleased to announce that they have entered into an agreement to collaborate on projects of mutual interest with a goal to advance and commercialize early - stage health - related discoveries.

What: Shares of Alkermes (NASDAQ: ALKS) shed up to 43 % of their value on extraordinary volume in early morning trading today after the company announced that its orally administered drug ALKS - 5461, indicated for major depressive disorder (MDD), failed to meet its primary endpoints in two late - stage studies.

According to the Greens, since these drugs interfere with implantation in the womb, they destroy human life in the earliest stage of development.

The early stages of labour when you are confident you will be able to breathe your way through the pain of labour and will have no need for any drugs, this can change later on!

Thousands of people suffering from early stage Alzheimer's will be denied drugs on the NHS following a ruling by the health watchdog today.

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These methods range from the administration of drugs at early stages, through to «vacuum aspiration» and medical induction at the latter stages of the pregnancy.

Their first visit was to CytoCybernetics, where CEO Glenna Bett explained how her company has developed a system that uses computers and live human cells to screen drugs in their early stages of development, to determine whether they may cause any potentially deadly side effects.

24 Love and Other Drugs, a film by Edward Zwick, director of the 2006 film Blood Diamond, depicts an artist named Maggie (Anne Hathaway) in the early stages of Parkinson's disease.

At least four experimental Ebola drugs were in early stages of development.

Being a young doctor during the early stages of HIV in western Europe, it was amazing the change that occurred both in lives, but also in attitudes toward HIV, when we developed antiretroviral drugs.»

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

In a report, the commission argues that «[g] lobal governments should unite to offer multibillion - dollar incentives for drug developers, and pharmaceutical companies should pool their billions in support of early - stage research,» as Kelly Servick wrote Thursday at ScienceInsider.

This lecture illustrates the early stages in the planning and discovery of propranolol, an adrenaline beta - adrenergic receptor antagonist, and cimetidine, a histamine H2 - receptor antagonist — the first examples of clinically useful drugs from each of these classes.

As well as revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain disease.

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

Professor Michael Seckl, lead author from the Department of Surgery and Cancer at Imperial said: «Although these are very early - stage results, and are yet to be applied to patients in trials, they suggest the addition of a very cheap diuretic may extend the amount of time we can use the cancer drug erlotinib.

For most of these early - stage drugs, developers haven't assessed just how selectively they trigger the painkilling pathway over respiratory suppression.

With the initial contract of $ 24.9 million over the next 18 months, Mapp Pharmaceutical will manufacture a small amount of the drug for early - stage clinical studies to demonstrate its safety and efficacy in people.

So now, with late - stage clinical failures piling up, the U.S. Food and Drug Administration (FDA) has set off down a path to adapt those standards as researchers are pushed inexorably into earlier and earlier forms of the disease, ahead of the brain damage inflicted by Alzheimer's.

Should doctors treat patients in early stages of Parkinson's disease, when drug side effects may be worse than the symptoms they alleviate?

Flies exposed continuously to the drug from an earlier stage in life lived longer than those who began dosing later in life, possibly indicating a cumulative effect of the drug.

Detection of dementia at the earliest stages has become a worldwide priority, because drug treatments, prevention strategies and other interventions will likely be more effective very early in the disease process, before extensive brain damage has occurred.

A test for the early stages of the condition would be helpful in efforts to develop drugs that can slow its progression.

Therefore, FDA is encouraging industry to use existing knowledge to do earlier stage simulations of the absorption, metabolism, and excretion of drug candidates.

Since small, early - stage cancers are the most responsive to drug treatments, screening is an important aspect of follow - up care for breast cancer patients, and early detection is critical in tailoring appropriate and effective therapeutic interventions.

A recently developed drug was significantly better at detecting recurring prostate cancer in early stages, in research published in the August 2015 issue of The Journal of Nuclear Medicine.

Later this year early - stage human trials will begin for the drug, a collaboration of CSHL and clinicians at the Monter Cancer Center of North Shore - Long Island Jewish Hospital.

Giving the drug at a different dose, or treating patients for longer or at an earlier stage of Alzheimer's might yield better results, but «the jury is still out,» Hale says.

He used a drug to inhibit the early stage production of internal glutamine while also limiting the uptake of external glutamine.

As part of drug discovery, one of the earlier stages is you take a huge library of chemical compounds and you screen them with an assay for malaria or TB and you see if that chemical compound kills the parasite or bacteria.

The response to the drug is typically good in the early stages of the disease but diminishes over time for reasons that are not understood.

«DATATOP subjects were recruited at early disease stages, without apparent signs of dementia and prior to needing dopamine - supplementing drugs, making this cohort ideal for studying PD progression,» explains Jing Zhang, MD, PhD, Department of Pathology at the University of Washington School of Medicine (Seattle).

Professor Geoff Pilkington, study co-author and Head of the Brain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the brain.

«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

The drug, bexarotene, was found to reduce levels of the neurotoxic protein amyloid - beta in experimental mice with late - stage Alzheimer's but to increase levels during early stages of disease.