Sentences with phrase «early targeted treatments»

The ultimate goal of JPND is to find cures for neurodegenerative diseases and to enable early diagnosis for early targeted treatments.

Not exact matches

Furthermore, an early - stage study pumping up the dose of its hemophilia A treatment — which aims to be a one - time therapy for the rare blood clotting - related disease — appeared to hit its targets without serious side effects.

After many setbacks, researchers have been trying different approaches to treating the neurodegenerative disease, such as starting treatment earlier and finding new ways to target the brain.

In the drive to improve early detection and treatment of cancer, a pair of Toronto scientists has developed a unique technology that combines contrast agents with targeted, long - lasting nano - particles for use in multiple medical imaging platforms.

This early stage research will explore how the virus targets stem cells and provide the starting point to develop new treatments that seek out the tumour and spare the surrounding healthy brain tissue.

«With further validation, this radiotracer could also potentially be used to perform targeted biopsies for precise tissue analysis, which could lead to earlier, more appropriate treatment for prostate cancer patients.»

«Early diagnosis helps target appropriate treatments, including what medications not to give.

It could in future allow the PARP inhibitor olaparib to become a standard treatment for advanced prostate cancer, by targeting the drug at the men most likely to benefit, picking up early signs that it might not be working, and monitoring for the later development of resistance.

This understanding of cancer's evolution has key implications for treatment, he noted, «In addition to pointing out that we will need to target driver genes that are mutated early in cancer, this evolutionary approach provides a method that accurately characterizes which genes are being mutated early and late.

For all these early successes, biologists see targeted cancer therapy as a treatment rather than a cure.

Seed treatments for row crops, such as corn, cotton or soybean, target early - season pests that are in the soil when the seed is planted.

«Although it's still early days for this line of research, these findings provoke the hypothesis that MHCII + innate lymphoid cells may be an important pathway to therapeutically target in the treatment of some chronic inflammatory diseases,» suggests Sonnenberg.

The measurement of blood levels makes it possible to initiate individual, more targeted treatment at an early stage, thus preventing another flare - up of the disease.

For example, these factors might be useful for early detection of the diseases through a simple blood analysis, or even serve as new targets for possible treatment,» concludes the researcher.

The pair has invented a nanotech - based early - detection system that might one day deliver targeted treatments.

New research published today in Disease Models & Mechanisms indicates that early intervention should be a key target in the development of new therapeutics for Friedreich's ataxia, as current treatments may be administered too late to target the disease effectively.

These exercises use a «bottom - up» approach, targeting more basic cognitive processes early in the treatment to strengthen cognitive foundations, then moving on to training focused on more complex cognitive functions later in the program.

Early, consistent treatment of patients that also targets the bacteria is very important,» he stresses.

«The ability to identify, characterize and validate gene targets that strongly associate or correlate with disease development or metastasis will facilitate early detection and appropriate treatments to tackle the disease at an early stage or before metastasis occurs.»

The collection contains over 20,000 different samples of Salmonella, with half of the samples housed at the Cancer Research Center where researchers affiliated with MU focus on three areas of cancer research: early detection, targeted treatment and new, effective chemotherapy.

Thus, the results open the way to discover and test potential ALS therapies targeted at the early stages of the disease, when treatment is most likely to be effective.

Early radiation treatments caused severe side - effects because the energy beams would damage normal, healthy tissue, but technologies have improved so that beams can be more accurately targeted.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

This way, we can actually monitor and detect those really subtle changes that we're really targeting so that we can not only diagnose glaucoma earlier, but we hope to be able to adjust the treatment very precisely for the people who are being treated for glaucoma to minimize the vision loss that takes place.

Treatment with AFF 1 or vehicle control was initiated in mThy1 - AS mice at age 3 mo, when early sensorimotor deficits first appear — similar to the target population for the first rollout of the human vaccine.

Imagine a world where cancer could be easily prevented with a simple vaccination; where the earliest stages of cancer could be detected, treated and cured before they had a chance to spread; and where more advanced cancers had a reliably tested, genetically targeted treatment customized to each patient.

Join the Sibley breast cancer team to learn the latest on breast imaging, chemotherapy and hormonal therapy, Her2 targeted therapy with early stage breast cancer, making sense of breast cancer genetics, demystifying radiation treatment and fertility preservation.

City of Hope patients have access to a wide variety of clinical trials looking into early - detection for lung cancer, the newest chemotherapy treatments, targeted therapies and surgical and radiation approaches — all with the goal of helping extend life.

Clinical Trials Research and Billing First in Human / Early Phase PET in Oncology Case - Based Dose Reduction in Pediatric Nuclear Medicine: Practical and Necessary Radioiodine Therapy for Hyperthyroidism: The State of the Art Spondylodiscitis: Role of Imaging for Diagnosis and Monitoring Treatment Response Current Status and Future Prospects: PET and SPECT Instrumentation Alternative Payment Models and Value - Based Health Care: Nuts and Bolts Maximal Tolerated Activity of Radioactive Iodine for Metastatic Thyroid Cancer Teaching Old Radiopharmaceuticals New Tricks Intraoperative Detection Devices and Probes Molecular Imaging of Lung Inflammation Standardization of Advanced PET / SPECT Data Acquisition and Analysis Thyroid Cancer Management: Novel Therapeutics and Management Options Targeting Radionuclide Therapy in Various Non-Malignant Arthritic Conditions Using Radiosynoviorthesis (RSO) Are You Prepared for a Radiation Accident?

They are seeking ways to target the disease at its earliest stages, so that innovative treatments might be developed to significantly delay disease progression even in patients who do not respond to current medical and surgical treatments that only lower pressure in the eye.

The operationalization of mild cognitive impairment (MCI) led to targeting earlier symptomatic cases of the illness and treatment strategies based less on pathology and more on a chance to halt or slow decline than there would be earlier in the disease.1 With the development of amyloid imaging, MCI due to AD diagnosis was refined, 2 and early - stage AD was extended further to include preclinical AD, 3 wherein a positive amyloid positron emission tomography (PET) scan or diagnostic low levels of cerebrospinal fluid β - amyloid (Aβ) indicated the presence of pathology in people who were cognitively normal.

A finding that opens the door to improving retinal prosthetic devices, targeting treatments to restore damaged retinal circuits, and improving early detection of retinal diseases.

Our aim is to enable earlier disease detection and more targeted treatment, which ultimately helps prevent heart attack, stroke, and other cardiovascular events.

At first Dean's doctors couldn't believe he was asking for more, but Dean had calculated that it would take him seven days to get through a batch of treatment in hospital, and made it his target to reduce that by a day and «go home early».

Treatment specifically targeting circulating microfilariae may be started as early as 3 - 4 wk following adulticide administration.

The ASPCA believes that this approach — promoting education in the appropriate care, training and supervision of dogs as well as state and local laws that address licensing, reproductive status, chaining / improper confinement, cruel treatment and at - large dogs; imposing civil and criminal liability on guardians for their negligent and reckless behavior; and targeting problematic dogs and guardians early with progressively escalating penalties — constitutes the most compassionate, fair, efficient and ultimately effective means of resolving concerns related to dangerous dogs in the community.

The American Association of Equine Practitioners (AAEP) recommends targeted tapeworm treatment once a year, in the late fall or early winter after tapeworm transmission ends due to cold weather.10 With just a single dose, Quest ® Plus Gel treats and controls bots, encysted small strongyles and roundworms.

Indeed, it says its technology will allow doctors to access early - stage lung cancer without incisions, allowing for more accurate diagnosis, as well as more targeted treatment.

The asks focus on setting targets and includes issues such as incarceration, early childhood, food access and security and specifically calls on governments to invest in a holistic approach to the social and emotional wellbeing for Aboriginal and Torres Strait Islander people that supports prevention, treatment and opportunities to strengthen cultural identity and social inclusion.

In addition, many of the early intervention programs that have been shown to have positive treatment effects are resource intensive and target high - risk families, on the basis of socioeconomic status, childhood disabilities, parental substance use, or child maltreatment.1

Preventing Early Child Maltreatment: Implications from a Longitudinal Study of Maternal Abuse History, Substance Use Problems, and Offspring Victimization Appleyard, Berlin, Rosanbalm, & Dodge (2011) Prevention Science, 12 (2) View Abstract Presents the findings of a study focused on improving child maltreatment prevention science in terms of specific implications for child maltreatment prevention, including the importance of assessment and early intervention for maternal history of maltreatment and substance use problems, targeting women with maltreatment histories for substance use services, and integrating child welfare and parenting programs with substance use treatEarly Child Maltreatment: Implications from a Longitudinal Study of Maternal Abuse History, Substance Use Problems, and Offspring Victimization Appleyard, Berlin, Rosanbalm, & Dodge (2011) Prevention Science, 12 (2) View Abstract Presents the findings of a study focused on improving child maltreatment prevention science in terms of specific implications for child maltreatment prevention, including the importance of assessment and early intervention for maternal history of maltreatment and substance use problems, targeting women with maltreatment histories for substance use services, and integrating child welfare and parenting programs with substance use treatearly intervention for maternal history of maltreatment and substance use problems, targeting women with maltreatment histories for substance use services, and integrating child welfare and parenting programs with substance use treatment.

MSPCC targets its children's mental health public policy goals to support proven efforts, improving capacity for early identification and treatment, and reforming practices that inhibit school success.

The presentation addresses the empirical foundations of schema theory by shedding light on the role of early maladaptive schemas in depression etiology and reviews the clinical evidence of schema therapy as a possible treatment option for (chronic) depression: Limited evidence suggests that ST by targeting self - referential cognitive schemas (EMS) which mediate the effects of early life adversity on vulnerability towards and maintenance of depressive disorders in the sense of distal risk factors could be an effective treatment for depression and a feasible alternative to CBT (Brewin et al. 2009; Carter et al. 2013; Malogiannis et al. 2014; Renner et al. 2016).

Treatment needs to be targeted at major modifiable risk factors and its outcome measured objectively.26 It should preferably be at an early age as conduct disorder can be reliably detected early, 5 has high continuity, 27 is amenable to treatment at a young age, 4 and is very hard to eradicate in older children.28 In this section I discuss interventions for general aggressiveness only in children under 12; interventions targeting youth crime have been excellently reviewed by FarrTreatment needs to be targeted at major modifiable risk factors and its outcome measured objectively.26 It should preferably be at an early age as conduct disorder can be reliably detected early, 5 has high continuity, 27 is amenable to treatment at a young age, 4 and is very hard to eradicate in older children.28 In this section I discuss interventions for general aggressiveness only in children under 12; interventions targeting youth crime have been excellently reviewed by Farrtreatment at a young age, 4 and is very hard to eradicate in older children.28 In this section I discuss interventions for general aggressiveness only in children under 12; interventions targeting youth crime have been excellently reviewed by Farrington.29

The intervention group received usual care plus 5 sessions of cognitive behavioural therapy during the first 12 weeks and further targeted cognitive behavioural therapy (2 to 3 sessions per week) if early signs of relapse were present (e.g. racing thoughts, suspiciousness; assessed by fortnightly questionnaires or by the treatment team).

Type of prevention consisting of activities targeted to families in which abuse has already occurred and include early intervention and targeted services, such as individual, group, and family counseling; parenting education - such as Parent - Child Interactive Therapy (PCIT); community and social services referrals for substance abuse treatment, domestic violence services, psychiatric evaluations, and mental health treatment; infant safe - haven programs; family reunification services (including follow - up care programs for families after a child has been returned); temporary child care; etc..

We urgently need early identification of eating disorders and the delivery of quality, targeted treatments at evidence - supported durations.

Anxiety sufferers are best helped by understanding emotional conflicts, environmental and genetic factors with treatment that may include talk therapy, CBT, stress reduction techniques, Somatic Experiencing (SE) and EMDR Therapy to target early trauma, memories and present - day distress.

Although significant progress has been made in recent years in relation to the identification and treatment of anxiety in preschool children, it remains unclear which children should be targeted for early intervention and what the focus of early intervention should be.

[3] If the aim of early intervention is to decrease the presence of long - term anxiety disorders, then it is important to identify which factors lead to increased anxiety over time and, therefore, which variables should be targeted in treatment.