Sentences with phrase «early than mice»

Not exact matches

The mice died a few months earlier than untreated animals.

Yet, in mouse embryos the researchers found that the human enhancer was active earlier in development and more active in general than the chimpanzee enhancer.

The scientists exposed a group of mouse lemurs to moderate chronic caloric restriction (30 % fewer calories than their peers consuming a normal diet) from the outset of early adulthood (Restrikal cohort, see visuals below).

Then, he found that mice lacking Klotho died young, after developing arteriosclerosis and other age - related conditions much earlier than normal (Science, 7 November 1997, p. 1013).

Compared with earlier methods to tweak the genomes of bacteria, plants, laboratory mice and human cells, the Crispr - Cas9 gene - editing method is fast, precise and cheap, an order of magnitude better than the others.

The human early embryo is so different from the mouse that it is almost «like starting over on a process that took more than ten years».

Using these mice, the researchers found that if they triggered CHI3L1 production early after administering bleomycin, the mice fared well, experiencing less injury, less damage and less scarring than controls.

Spinal cord neuropathology showed higher pathology scores in demyelination, meningitis, perivascular cuffing (inflammation), and overall pathology in mice that had been given resveratrol during the early phase compared with mice fed a control diet, whereas mice treated with resveratrol during the entire treatment period had significantly higher pathology scores in meningitis and overall pathology than controls.

The authors also found abnormalities in the subthalamic nucleus occur earlier than in other brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington's disease.

Mice that were previously exposed to early - life stress performed worse than control animals and demonstrated poor learning and memory skills.

When the researchers introduced these microRNAs into mice prone to B - cell lymphoma, tumors formed far faster, and the mice died from their cancers earlier than those without the molecules.

Sagawa and colleagues compared mice whose mothers had received 30 % fewer calories during pregnancy with normal controls and found that the underweight pups experienced a shift in timing: the normal increase in blood leptin a week earlier than usual.

When investigators at the Stanford University School of Medicine applied light - driven stimulation to nerve cells in the brains of mice that had suffered strokes several days earlier, the mice showed significantly greater recovery in motor ability than mice that had experienced strokes but whose brains weren't stimulated.

Mice with the PER1 phosphorylation defects ate earlier than other mice — causing them to wake up and snack before their sleep cycle was over — and ate more food throughout their normal waking perMice with the PER1 phosphorylation defects ate earlier than other mice — causing them to wake up and snack before their sleep cycle was over — and ate more food throughout their normal waking permice — causing them to wake up and snack before their sleep cycle was over — and ate more food throughout their normal waking period.

As expected, mice with a mutated PER2 had sleep defects, dozing off earlier than usual.

In some ways, hAPP mice better model the earlier mild cognitive impairment stage of AD (MCI - AD) than the dementia stage (10).

In addition, this is not the only case in which the regulatory circuits that control early embryonic development in humans show greater similarity to those employed in bovine embryos than to those that operate in the mouse system.

The study confirms that house mice were already a fixture in the domiciles of eastern Mediterranean hunter - gatherer villages more than 3,000 years before the earliest known evidence for sedentary agriculture.

Earlier studies had suggested that animals — including fruit flies, dogs and mice — live longer when they ate about 25 percent fewer calories than normal.

Furthermore, whereas XpdTTD / TTD mice developed kyphosis earlier than wt animals (onset ~ 3 mo versus 12 — 20 mo), compound heterozygous XpdTTD / † XPCS mice did not (Figure 3B).

In an operant test R6 / 2 transgenic mice (240 - CAG repeats, B6 congenic background) were less able to acquire lever pressing than control animals at an age where motor function is only mildly affected (from 9 weeks), with this deficit being both more pronounced and detected earlier (from 5 weeks) where reinforcement was not solely contingent on responding.

They found that the mice developed earlier and more severe disease than mice that had normal Tob1 expression in all cells including CD4 +.

«Of course, it is not known when aging - associated changes in microglial activities begin in the human brain, but these results in mice suggest that it may be earlier than we had previously appreciated,» Watters says.

«We show in a mouse model that it may begin earlier than we thought,» Watters says.

Sullivan and her colleagues found that, on average, taste information began to influence the trajectory of the mouse cursor, and thus the choice process, almost 200 milliseconds earlier than health information.

This strain showed a highly virulent phenotype, with rapid multiplication during the early stage of infection in a murine model of TB with excessive lung inflammation, and infection with this strain resulted in more rapid death of mice than infection with the reference H37Rv strain.

When these Stat5a − / − mice were bred to MMTV - tva mice, infected with RCAS - caErbb2, impregnated 4 days post infection, and analyzed at I10, the resultant early lesions exhibited significantly lower levels of pSTAT5 than did the lesions in Stat5a + / + mice (Figure 5A) confirming the predominance of STAT5a in the mammary gland.

It was even lower in the early lesions of I10 mice than in those of age - matched virgin mice, suggesting that the molecular network activated in normal epithelia at involution to arrest the cell cycle (Figure 1 — figure supplement 3B) also operates in these premalignant cells.

Since pSTAT5 + cells occur at 10-fold higher frequency than pSTAT3 + cells in early lesions from our mouse model (18 % vs 1.8 %), C188 - 9 is effectively a STAT5 inhibitor in this setting.

Therefore, LMU researchers argue that bovine embryos might well be a better model for early human development than the mouse system.

The chronically stressed mice had decreased immune function and experienced tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.

This early game of cat - and - mouse is really fun, and had my heart racing more than the actual confrontation later in the match.

Of course, it's still very much early days for Intel's league, and the VR games involved, but virtual reality brings forth an interesting element in that it's closer to real sports in terms of being a more physical activity than traditional gaming — a «purer» sports experience compared to sitting at a mouse and keyboard.

With that Lightspeed technology mentioned earlier, Logitech says that the G603 should provide more than 500 hours of battery life and reliability that surpasses many wired mice.