Sentences with word «ectodomain»

To achieve this, Crosnier and colleagues recently developed a method of expressing the entire ectodomains of functional recombinant Plasmodium proteins and used it to compile a large library of 42 proteins [27].

Increasing evidence suggests that the synaptic functions of the amyloid precursor protein (APP), that is key to Alzheimer (AD) pathogenesis, may be carried out by its secreted ectodomain.

This resource of extracellular P. falciparum merozoite proteins, which now contains 62 full - length ectodomains, will be a valuable tool in elucidating the function of these proteins during the blood stages of infection, and facilitate the comparative assessment of blood stage vaccine candidates.

Briefly, full - length secreted molecules and the entire ectodomains of membrane - embedded proteins were identified using transmembrane [28], GPI - anchor [29], and signal peptide [30] prediction software.

A band consistent with the entire ectodomain was observed by immunoblotting for the majority of the proteins and their expression levels were quantified.

FMP2.1 is a lyophilized preparation of the ectodomain of the 3D7 clone of P. falciparum AMA1 [21].

Consequently, the functional characterization of extracellular parasite proteins has typically been restricted to smaller subfragments that can be expressed rather than the full - length protein or entire ectodomain, which is more likely to be representative of the native protein.