Coordinated misexpression of the EFTFs (pax6, tbx3, rx1, nr2e1, six3, and six6) and otx2 in developing embryos results in formation of
ectopic eye tissue [7].
Similarly, EFTF - expressing pluripotent cells formed
ectopic eye - like structures when transplanted to the embryonic flank.
Similar paths are taken by RGC axons exiting
ectopic eyes generated by transplantation of eye primordia [13]--[15].
Not exact matches
Ectopic cilia are one or several hairs that grow abnormally through the conjunctiva and come into contact with the surface of the
eye (cornea).
Clinical signs of
ectopic cilia include squinting, rubbing of the
eye, ocular tearing / discharge, and / or redness.
Breed health concerns may include progressive retinal atrophy, pyloric stenosis, sebaceous gland tumors, keratocanthoma, hydrocephalus, intervertebral disc disease, entropion (usually lower lids), distichiasis,
ectopic cilia, caruncular trichiasis, keratoconjunctivitis sicca («dry
eye»), prolapse of the gland of the nictitating membrane («cherry
eye»), refractory corneal ulceration and pigmentary keratitis and urolithiasis (calcium oxalate, struvite, silica).
Ulcers can also occur secondary to «rolling in» of the eyelids (entropion) causing the lashes to rub on the surface of the
eye, extra eyelashes (
ectopic cilia), or inadequate tear production (dry
eye syndrome).