Not exact matches
Already, researchers have used CRISPR / Cas9 to
edit genes in human
cells grown in lab dishes, monkeys (SN: 3/8/14, p. 7), dogs (SN: 11/28/15, p. 16), mice and
pigs (SN: 11/14/15, p. 6), yeast, fruit flies, the worm Caenorhabditis elegans, zebrafish, tobacco and rice.
Genomic RNA
editing and its impact on Ebola virus adaptation during serial passages in
cell culture and infection of guinea
pigs
With gene -
editing tools such as CRISPR, scientists can now eliminate immune - provoking sugars from the surface of
pig cells, introduce human genes that regulate blood coagulation to prevent dangerous clots, and snip out viral sequences that some fear could infect a human host.
Researchers used the CRISPR / Cas9 gene
editing technique to introduce a segment of a human gene causing Huntington's, with a very long glutamine repeat region, into
pig fibroblast
cells.
In the new study, a team led by Harvard University's George Church — one of the pioneers of the CRISPR technique — used gene
editing to remove all the copies of porcine endogenous retroviruses (or PERVs) from their
pig cells» DNA.
To further facilitate genome
editing in
pigs, we report here establishment of a
pig line with Cre - inducible Cas9 expression that allows a variety of ex vivo genome
editing in fibroblast
cells including single - and multigene modifications, chromosome rearrangements, and efficient in vivo genetic modifications.