Sentences with phrase «editing approaches»

Suk See De Ravin and colleagues applied an ex vivo gene editing approach using the CRISPR - Cas9 platform to chronic granulomatous disease (CGD), a genetic disorder with limited treatment options that leads to life - threatening infections and often requires long - term antibiotics.
2) If ES cell clones are not available from the IKMC / IMPC resource, mouse models will be generated using genome editing approaches such as CRISPR / Cas9 nuclease technology (on C57BL / 6N genetic background only) and may cover constitutive knock - outs or point mutations.
We have deliberately built a broad pipeline of product candidates that leverage different editing approaches, delivery approaches and disease targets.
«To turn the new gene editing approach into a therapy for blood disorders, the British - 198 mutation would have to be introduced into blood - forming stem cells from the patient,» says Professor Crossley.
The track record of earlier gene - editing approaches suggests that the CRISPR companies pursuing medical therapies have a long road ahead.
«We used P53 and KRAS to demonstrate the principle that the CRISPR editing approach and the organoid transplantation approach can be used to very quickly model any possible cancer - associated gene.»
A new gene editing approach eases the effects of sickle cell disease in blood cells isolated from patients.
The study, which will be published in the June 3, 2011 issue of Cell Stem Cell, but is currently available online, demonstrates that the gene - editing approach developed by Salk professor Juan Carlos Izpisúa Belmonte, Ph.D., and his team, provides an efficient and safe tool for cell engineering, and opens the way for gene editing - based stem cell therapies suitable for clinical applications.
Since complex oligonucleotide treatment comes with many challenges, researchers have begun to explore genome editing approaches for exon skipping.
A lot of distinct editing approaches this year: the musical trance rhythms of memory (Ali, Millennium Mambo), carefully calibrated shocks and discordances (Mulholland Dr.), an excited buildup to an unexpectedly mellow climax (Spirited Away).
Conditional mouse models using genome editing approaches can not be generated within the frame of this call
That's attached to the progress of sequencing technology, the ability to edit cells, and other gene editing approaches have been transformative in the immunotherapy world in recent years.
The work is among the first to apply a genome editing approach to deafness in animals, Liu says.
They are now working toward human trials for the gene - editing approach.
The latest developments in CAR - T translation and manufacturing including alternate gene transfer methods to deliver CARs; novel gene editing approaches, advances in CAR design to improve safety and efficacy, and progress in creating an «off - the - shelf» allogeneic CAR - T therapy.
Mouse models can be developed using either genome editing approaches (C57BL / 6N genetic background only) or by injecting targeted ES cells of the IKMC resource.
In the very next fight, he drops that approach entirely and goes for the kinetic quick - editing approach, which he does as well as anybody.
On the one hand, most people seem to agree that he did an admirable job of translating Suzanne Collins» popular dystopian sci - fi thriller into cinematic form; on the other hand, some of Ross» stylistic choices with Hunger Games (specifically, the disorienting shaky cam / editing approach) left many viewers feeling disgruntled.
Your Resume Must Be Concise While length doesn't matter as much as it used to, you should still make every effort to maintain focus and an «if in doubt, cut it out» editing approach.
I love the simple clean lines and how you've taken an edited approach.
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