Sentences with phrase «effect drive levels»

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The state's ride - hailing law, which is set to take effect June 29, blocks Level 2 and 3 sex offenders from driving for the companies, which allow users to summon a driver with the push of a button on their smartphone.

ALBANY - New York lawmakers voted this week to block low - level sex offenders from driving for companies like Uber and Lyft, closing a loophole in the state's soon - to - take - effect law regulating ride - hailing.

Because they can't ethically subject youth to alcohol to study its effects, researchers use the developing brains of rats to understand the effects of «intermittent alcohol exposure» — the equivalent of drinking to a blood - alcohol level of.08 (the legal limit for driving while impaired) three or four nights a week.

First, the study is based on data from only six states where this information is captured; secondly, the effects of drugs on driving performance and crash risk vary by drug type, dosage, and the driver's physiological response and tolerance level.

The immune system naturally drives down viral levels, making it difficult to separate the effects of the drug, he noted.

The analysis assumes that the climate - driven human contribution to sea level rise is spread evenly across global oceans, discounting localized effects.

The increase in the Aβ42 / Aβ40 ratio (driven by a decrease in plasma Aβ40 levels) could also be related to the observed decrease in expression of CLU as part of the relaxation effect (P = 0.00045).

If the insulin resistance is now driving the high insulin levels, even dietary changes may have a very modest effect on reducing the insulin levels.

An increase in levels of estrogen can also cause a reduction in testosterone, leading to fatigue, increased body fat, lower sex drive, loss of muscle, and enlarged prostate - all undesirable side effects.

Then cozy up with Parsley Health founder Robin Berzin and Parsley Health LA Director of Medicine Jeff Egler for an interactive discussion on how hormones effect your sex drive, stress levels, and how well you're sleeping.

Aside from directly impacting your immune function, another explanation for why poor sleep can have such varied detrimental effects on your health is that your circadian system «drives» the rhythms of biological activity at the cellular level.

Then cozy up with some tea as Parsley Health founder Robin Berzin and Fern Olivia lead an interactive discussion on how hormones effect your sex drive, stress levels, and how you feel every day.

That has the effect of increasing insulin sensitivity, which in turn drives down blood sugar levels.

Many researchers are studying the potential effects of Mucuna pruriens which range from being able to increase levels of human growth hormone (and other potentially anabolic hormones) to increasing testosterone and improving sexual drive and promoting positive feelings.

The effect of this natural decline in HGH levels leads to consequences for our bodies and minds that include what we usually think of as the results of aging: increased body fat and cholesterol, greater risk of heart and liver disease, depression, and diabetes, disturbed sleep, brittle bones, wrinkled skin, thin, greying hair, loss of muscle mass, and reduced sexual drive.

When levels are low, an adverse effect can occur where you have loss of strength, mood swings, lack of interest in things you once did, low sex drive and general fatigue.

While striving to be a family driven adventure film, Jumanji is a moderately successful teen drama but too dependent on special effects to thrill at a predictable and mediocre level.

A rigorous 2011 random - assignment study by researchers from the University of Wisconsin — Madison examined the effects of a district - level intervention to support data - driven decision making in more than 500 schools in 59 school districts across seven states.

Using its four - wheel steering, active roll bars, air springs, torque vectoring, four - wheel drive and colossal Pirellis to full effect, the Turbo can generate levels of lateral acceleration you'd simply not credit for a car of this size.

«They are very comprehensive and finely tuned systems designed to provide a higher level of performance without a significant effect on the overall driving experience,» said Dickens.

All too often a powerful front - drive hatchback loses the plot when it comes to traction out of corners but the Civic Type R uses its limited - slip differential to great effect, providing a level of grip and handling composure usually reserved for far more expensive rear - wheel drive machinery.

The application of Toyota Optimal Drive across the Toyota Auris range in 2009 has already effected a significant improvement in the model's environmental performance, lowering CO2 emissions to segmentbest levels.

The initial value of the ratio determines the reference growth level, from which the actual stock price may deviate as an effect of random external disturbances, and c) a driving component ensuring the diffusive behaviour of stock prices.

The initial value of the ratio determines the reference growth level, from which the actual stock price may deviate as an effect of random external disturbances, and iii) a driving component which ensures the diffusive behaviour of stock prices.

As a story - driven action RPG, what would Dead Effect 2 be without a leveling system?

The original Mass Effect was something special for us at Screen Rant, a brilliant story and character driven space opera that brought the RPG elements and gameplay style of BioWare's previous similar game (Knights of the Republic) to another new level.

The warming trends in looking at numerous 100 year temperature plots from northern and high elevation climate stations... i.e. warming trends in annual mean and minimum temperature averages, winter monthly means and minimums and especially winter minimum temperatures and dewpoints... indicate climate warming that is being driven by the accumulation of greenhouse gases in the atmosphere — no visible effects from other things like changes in solar radiation or the levels of cosmic rays.

More ground turns from white reflective snow to black, heat absorbant dirt.The same effect occurs as sea ice is lost.The corals blanch, and, as I stated last year on this site, the shutdown of the north Atlantic current will occur, since the salinity level studies I spoke of last year, off Greenland, continue to show that the upwelling mechanisms driving the North Atlanic current are in severe jeapordy, because the change in salinity levels effects the driver of the current, the upwelling and downwelling of different salinity levels off Greenland.

Steric sea level is driven by volume changes through ocean salinity (halosteric) and ocean temperature (thermosteric) effects, from which the latter is known to play a dominant role in observed contemporary rise of GSSL.

a) atmospheric CO2 from human activity is a major bause of observed warming in the 1980's and 1990's, c) that warming is overstated due to a number of factors including solar effects and measurement skew d) the data going back 150 years is of little reliability because it is clustered so heavily in northeast america and western europe rather than being global e) the global climate has been significantly shifting over the last thousand years, over the last ten thousand years, and over the last hundred thousand years; atmospheric CO2 levels did not drive those changes, and some of them were rapid.

Among them, to you Leonard, are: what do you think constitutes «small AGW» and catastrophic AGW, and to what extent have you reviewed the biological / ecological literature that address the ecosystem's functional sensitivity of different warming levels (sufficient CO2 - driven ocean acidification alone likely qualifies as «catastrophic» — or are you separating warming from the other effects of high CO2?)

As you are aware sea level rise also has the effect of moving the grounding line proximally, which reduces the friction on the ice shelf or valley glacier without reducing the gravitational force which is driving the ice from the slopes beyond the coastal plain.

And to even claim four inches form CO2 since 1950 one would have to make the astonishing claim that whatever natural effect was driving sea levels higher since the mid-19th century suddenly halted at the exact same moment man began burning fossil fuels in earnest.

CO2 isn't pollution and at the practical levels we can drive it too I'm not sure there is any risk of negative effects.

If you can do so without being driven by desire simply to mock viewpoints different from yours, look at the ultra-slow effect of the thermohaline current, in addition to questionable ice - core CO2 measurements; the evidence is in different sensitive comparisons of delta CO2 levels with delta emissions levels, as well as isotope studies; nothing watertight proven but a lot of highly suggestive coherent evidence that it's bad science to neglect.

At the time, we (correctly) pointed out that this result was going to be hard to reconcile with continued increases in sea level rise (driven in large part by thermal expansion effects), and that there may still be issues with way that the new ARGO floats were being incorporated into the ocean measurement network.

The greenhouse effect would then drive the planet's temperature a bit higher still, which would drive a further rise in the gas levels... and so forth.

The observed effects of cryosphere reduction include modification of river regimes due to enhanced glacial melt, snowmelt advance and enhanced winter base flow; formation of thermokarst terrain and disappearance of surface lakes in thawing permafrost; decrease in potential travel days of vehicles over frozen roads in the Arctic; enhanced potential for glacier hazards and slope instability due to mechanical weakening driven by ice and permafrost melting; regional ocean freshening; sea - level rise due to glacier and ice sheet shrinkage; biotic colonisation and faunal changes in deglaciated terrain; changes in freshwater and marine ecosystems affected by lake - ice and sea - ice reduction; changes in livelihoods; reduced tourism activities related to skiing, ice climbing and scenic activities in cryospheric areas affected by degradation; and increased ease of ship transportation in the Arctic.

However if you simply pay a ticket you are in effect admitting guilt and unless you attend level one traffic school you will receive a point on your driving record and your insurance rates will go up.

The size effect is relevant to lawyers because (a) there is credible, recent evidence that size is correlated with innovativeness in law firms; and (b) as Rogers acknowledges, the higher levels of innovativeness are, in most cases, substantially driven by the «covariants» of size, rather than size itself.

Most — not all — auto policies are written with a clause to the effect of «if you travel outside your state of residence, and the state in which you are driving requires more coverage than this policy provides, this policy may be construed to provide the minimum required level of coverage.»

RED Driving School CEO Ian McIntosh says: «It is shocking that so many UK drivers have admitted to driving on drugs and this shows a worrying level of complacency by drivers about the effects of drugs on their dDriving School CEO Ian McIntosh says: «It is shocking that so many UK drivers have admitted to driving on drugs and this shows a worrying level of complacency by drivers about the effects of drugs on their ddriving on drugs and this shows a worrying level of complacency by drivers about the effects of drugs on their drivingdriving.

To command a recruiter's or hiring manager's attention, you need an eye - catching, results - driven, executive - level resume that clearly shows the positive effect you've had on your team, your department, and your company.

Parenting sense of competence was slightly lower among intervention recipients (β level, − 0.92 [95 % CI, − 1.40 to − 0.44]-RRB-, an effect driven by lower scores on the satisfaction subscale rather than by differences in self - efficacy (Table 4).

Perhaps one of nicest side effects of being a driven entrepreneur is the level of community activism Squires has engendered.