Sentences with phrase «effect in normal mice»

Not exact matches

They then injected the protein into elderly mice with normal immune systems, and found this reproduced the beneficial effects of cord plasma on both memory performance and LTP in the hippocampus whereas mice engineered to lack TIMP2 showed reduced LTP.

The drug had a potent effect — it prevented FOP extra-skeletal bone formation and also preserved limb motion and normal bone growth in young mice.

The researchers also administered a compound to normal mice that blocked TRPV4, and found that inhibiting TRPV4 also led to smaller reductions in bite force, similar to the effects of the mice engineered without the Trpv4 gene.

To determine what effect this had on fertility, Cook - Andersen's team set up an equal number of fertile male mice with 10 females lacking L2 in their eggs and 10 normal females.

In the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal micIn the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal micin osteoblasts from normal mice.

Notably, they also achieved the same effects on p300 and Tregs in mice by using a drug that inhibits p300 in normal mice.

Next, Liao and his colleagues compared the effects of cardiac stress on normal mice and on those lacking KLF4 in their hearts.

Intrigued, Turek joined with endocrinologist Joseph Bass, also at Northwestern, to study the effects of regular and high - fat diets in normal mice and mice with a dysfunctional Clock gene.

To test the effect of the change, Tsien and colleagues at the East China Normal University in Shanghai gave mice a slight shock in a training chamber while playing a loud tone.

The researchers, funded by the Medical Research Council (MRC), the Wellcome Trust and Cancer Research UK, compared the effects of two cancer - causing chemicals in normal mice and mice with the barrier defect (the knock - out mice).

Monitoring groups of mice, one group receiving normal levels of protein in the diet and the other group nourished with low levels of protein for five weeks, researchers were able to uncover the damaging effect a reduction of protein can cause to the structure of this vital organ.

To see if the effect also works in reverse, the team asked whether mice grown in a germ - free environment would express genes encoding complement components differently than mice grown under normal conditions.

In normal mice, ginkgo halved the volume of brain tissue injured after a stroke, but it had little effect on mutant mice that lacked heme oxygenase.

The researchers also showed that DENV NS1 caused similar levels of blood vessel leak in normal mice as in mice bred to have inhibited cytokine activity, suggesting that cytokines were not necessary for this effect.

In order to better understand the liabilities associated with reducing normal htt in adult mice, we evaluated the effects of a robust knock down of WT htt both in CNS and periphery in a conditional htt knock - down (KD) model induced by doxycyclinIn order to better understand the liabilities associated with reducing normal htt in adult mice, we evaluated the effects of a robust knock down of WT htt both in CNS and periphery in a conditional htt knock - down (KD) model induced by doxycyclinin adult mice, we evaluated the effects of a robust knock down of WT htt both in CNS and periphery in a conditional htt knock - down (KD) model induced by doxycyclinin CNS and periphery in a conditional htt knock - down (KD) model induced by doxycyclinin a conditional htt knock - down (KD) model induced by doxycycline.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

In both mice with Alzheimer's and normal mice, caffeinated coffee treatment significantly improved GCSF blood levels; neither decaffeinated coffee nor caffeine alone had this effect.

* Oddly enough, however, the experiments with fresh pancreatic islets and fat cells taken from the mice suggested that the positive effects of uncarboxylated osteocalcin on insulin only occurred at concentrations extremely low compared to those of undercarboxylated osteocalcin normally present in mice, while the effects on adiponectin and energy expenditure only occurred at normal to high concentrations.

The researchers also showed that regular feeding with the Lactobacillus strain caused changes in the expression of receptors for the neurotransmitter GABA in the mouse brain, which is the first time that it has been demonstrated that potential probiotics have a direct effect on brain chemistry in normal situations.

This study has examined the effect of alpha - lipoic acid on glucose uptake by cultured L6 muscle cells and different types of skeletal muscles in normal lean (+ / +) and severely insulin - resistant, obese - diabetic (ob / ob) mice.

Which do you prefer to use in normal conversation, Global Warming, Enhanced Greenhouse Effect, Climate Change, Climate Disruption, Carbon Pollution or Mickey Mouse?