Sentences with phrase «effect of a single gene»
Teasing out the effect of single genes in deafness is difficult.
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That pattern of inheritance would suggest the strong effect of a single gene mutation, and it would most likely crop up in families that had a lot of shared genes through the intermarriage of first cousins.
«So there could be a large effect of a single gene, but there is some other factor necessary for developing disease,» says Richard Lifton at Yale University, Connecticut, US, who led the new research.
Gene targeting makes it possible to study the effects of single genes, including those that don't occur naturally in mice.
The recent Nobel Prize winner explains how the technology of studying the effects of single genes has revolutionized the study of mammalian biology of human medicine.
Not exact matches
Some morphogenic gradients apparently yield but a single effect: If the concentration of a morphogen in a particular place is above a critical threshold, a target gene is activated; otherwise, it is not.
«It's important they've found this gene, but it took a sample of 20,000 people to find it, precisely because the effect is so small,» says Robert Plomin at the Institute of Psychiatry in London, and lead author of a groundbreaking study in 2007 which failed to find any single genes of disproportionate importance in intelligence.
Pinker says that the findings are a first step in demonstrating that intelligence relies on large numbers of genes, each with a tiny effect, rather than on single genes that have moderate or large effects, but which are so rare that none has yet been identified.
For each gene, the researchers compared the number of single letter mutations that alter the encoded protein versus silent mutations that have no effect.
«But it's remarkable that lowering levels of a single gene could have such a strong effect on the disease.
The power of the knockout is particularly evident with mental disorders in which a single gene has a large, obvious effect.
This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.
«There are hundreds of candidate genes to sort through, and a single genetic variant may have different effects even within the same family.
In this session, students will use pom - poms to investigate the effects of multiple genes on a single trait - in this case, height.
Years after receiving a single dose of gene therapy, patients on the hemophilia B trial continued to produce their own clotting factor from the normal transferred gene with minimal side effects.
Single loci with major effects in fire ants: the effects of the complementary sex - determining locus and the green beard supergene on gene expression
Due to the polygenic nature of the endurance phenotype3, it is highly unlikely that a single gene would have any greater magnitude of effect.
It is well known that purebred dog breeds are associated with differing susceptibility to specific malignancies, suggesting that selected breeds of dog are inheriting «at risk» alleles for very few genes, perhaps even a single gene, with a profound effect.
It is, therefore, no surprise that a number of genetic studies have been performed in this breed, with results proposing a single major gene with a large effect on seizures 8, 24 - 26.
Ultimately he discovered that the recessive nature of the disease is due to a single gene of major effect that causes choroidal hypoplasia, the primary CEA defect.
The discovery that concordance (similarity between siblings) for divorce among adults is higher among identical than fraternal twins suggests that genes may predispose some people to engage in behaviors that increase the risk of divorce.58 If parents» personality traits and other genetically transmitted predispositions are causes of single parenthood as well as childhood problems, then the apparent effects on children of growing up with a single parent are spurious.
The moderating effects of three single nucleotide polymorphisms (SNPs)(rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task.