Sentences with phrase «effect of cancer cell»
How long between application of sulforaphane and effect of cancer cell reduction.
https://nutritionfacts.org/ Not exact matches
Instead of being injected into the bloodstream and exposed to the rest of the body's tissue — with all the unpleasant side effects, as is the case with chemotherapy — these agents only target cancer cells.
As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?
The drug has an unfortunate side effect of tricking the immune system into attacking healthy cells, but the relative damage was insignificant compared to what cancer would have done to them.
As a physics teacher, I teach the therapeutic effects of gamma radiation in radiotherapy, along with the associated dangers (radiation can cause cells to become cancerous as well as kill cells that are already cancerous), but a common misconception among students is that cancer cells are rather like viruses or bacteria, a sort of alien cell that has entered the body, growing out of control with little relation to the surrounding cells.
Anthocyanins, the antioxidants responsible for giving blueberries their color, protect cells from the damaging effects of oxidation, which is often linked to chronic conditions like heart disease and cancer.
Phytic acid's chelating effect may serve to prevent, inhibit, or even cure some cancers by depriving those cells of the minerals (especially iron) they need to reproduce.17 The deprivation of essential minerals like iron would, much like other broad treatments for cancer, also have negative effects on non-cancerous cells.
Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).
A particularly effective treatment against many cancers, platinum - based chemotherapy, has the unfortunate side effect of damaging the hair cells in the ear that are responsible for sensing sound waves, Goldrich said.
You have probably heard a number of rumors about the effects of technology on your health; that having a cell phone next to your head can cause brain cancer, for example, or that pregnant women shouldn't stand near a microwave that is running because it may harm the fetus.
He also investigates the effects of 2HG inhibitors on cancer cells.
Disney said the precise binding of Targapremir - 18a to microRNA - 18a means a cancer drug that follows this strategy would be likely to kill prostate cancer cells without causing the broader side effects seen with many other cancer therapies.
Beyond the activity of the drugs, the plasmonic effects of the gold nanoparticles could heat the nanoparticles when they are subjected to light, attacking the cancer cells through a second route.
For a cancer with very high genetic diversity (like AML) however, the unintended effect of treatment is often to select for the most aggressive, resistant cells, clearing away their competitors and furnishing them with all the resources they need to flourish.
On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.
The problem is that when T cells are allowed to attack, they can destroy both cancer cells and healthy cells, leading to a wide array of side effects.
Fostamatinib's effect on microtubules seems to increase the stabilizing effect of paclitaxel, even in resistant cells, which in turn may prevent cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School of Medicine and co-author of the study.
Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.
Researchers at Nagoya University have been studying the therapeutic effect of T cells, vital disease - fighting components in our body's immune system, for fighting cancer.
The research, conducted in cell lines and mouse models, explored enhancing the cancer - killing effects of PARP inhibitors not only in regard to AML but also triple - negative breast cancer.
Another advantage is the very selective effect of the substance, which ensures that the cancer cells are killed off efficiently but healthy body cells remain unharmed.
Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.
Future research should not only compare how embryonic stem cells, iPS cells and adult stem cells differentiate, but focus on what effects the niche in which these cells will reside, when transplanted, will have on their characteristics, including tendencies to mutate into cancer cells, notes cell and stem cell biologist Olga Genbacev at the University of California, San Francisco, (U.C.S.F.) School of Medicine.
While testing the effect of many normal, non-cancerous, human cells on the sensitivity of cancer cells to chemotherapy, they found a specific sample of normal human skin cells that rendered pancreatic cancer cells resistant to gemcitabine.
The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.
This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.
In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.
To date, it was assumed that chloroquine increases the sensitivity of cancer cells to chemotherapy by means of a direct effect on the cancer cells.
By cutting gelsolin down to a specific fragment and putting it into chemo - resistant cancer cells, the international team discovered they could make these cells susceptible to the cancer - killing effects of cisplatin.
For example, light - activated switches can fine - tune anti-cancer drugs, so they target only cancer cells and not healthy ones, thereby eliminating the side effects of chemotherapy.
Different cancer cells might bear any number of variations that let them escape the drug's effects.
Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.
Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.
The study found that combining the two drugs had an increased effect of killing of cancer cells, while individually, the drugs have considerably less impact on cell viability.
The researchers looked at the synergistic effects of the two drugs on packaged DNA inside cancer cells.
Ana Soto, professor of cellular biology at Tufts University School of Medicine, and her colleagues were studying the effects of estrogen on a breast cancer cell line.
Hyder further tested luteolin and its effects on subduing the migration of triple - negative breast cancer cells throughout the body.
Because some of these neighbour proteins are as central and as global as the cancer - related proteins themselves, and link to so many other processes in the cell, there's a strong likelihood that drugs targeting them may have strong side - effects.
However, the use of NF - kB inhibitors in treating cancer is complicated by severe side effects related to immunosuppression caused by indiscriminate inhibition of NF - kB in normal immune cells.
Accordingly, depleting Numb - 1 and -2 from breast cancer cells reduced the levels of p53, whereas depleting Numb - 3 and -4 had no effect.
This could be a good way to test new types of drugs that target cancer cells specifically and spare patients the side effects from treatments if they are not working.»
She set up a lab dedicated to studying the effects of chemokines on cell death and cancer.
In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.
The common theory is that the cancer cell develops «internal resistance to treatment,» and overrides the toxic effects of the drug.
But there seems to be a powerful force in all cells that operates on its own clock, and understanding that force could give us a lot of insight into minimizing the effects of both cancer and aging.»
The phenomenon, known as Warburg effect, is typical for cancer cells and the mechanism behind is believed to benefit cancer cells by switching biochemical engines from energy manufacturing reactions to anabolic reactions, which primarily support growth of the cell size and proliferation.
The effects of the pactamycin analogs, called TM - 025 and TM - 026, were characterized in head and neck cancer cell lines, which cause the eighth most common cancer in the world.
«Cancer doesn't sleep: MYC oncogene disrupts clock, metabolism in cancer cells: Findings inform time - dependent treatment for reducing side effects, increasing effectiveness of cancer medications.&Cancer doesn't sleep: MYC oncogene disrupts clock, metabolism in cancer cells: Findings inform time - dependent treatment for reducing side effects, increasing effectiveness of cancer medications.&cancer cells: Findings inform time - dependent treatment for reducing side effects, increasing effectiveness of cancer medications.&cancer medications.»
«Ultimately, the virus is suppressing the immune system for its own benefit, and promoting the formation and proliferation of cancer cells may be just a side effect of that,» says Sharon Kuss - Duerkop, PhD, research instructor working in the lab of CU Cancer Center investigator Dohun Pyeoncancer cells may be just a side effect of that,» says Sharon Kuss - Duerkop, PhD, research instructor working in the lab of CU Cancer Center investigator Dohun PyeonCancer Center investigator Dohun Pyeon, PhD.
Next, the researchers tested the effects of RK - 33 and radiation in mice that had been injected with human prostate cancer cells that highly express DDX3.