Sentences with phrase «effect of cancer drugs»
Antibacterial drugs are sometimes prescribed to treat and prevent infection caused by bone marrow suppression, a side effect of cancer drugs.
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With support from pharma, we can refine these molecules over the next 10 - 20 years to develop anti-aging treatments which don't have the adverse effects of cancer drugs.»
Not exact matches
In addition to partnering with Celgene (celg) to better track negative drug side effects, IBM (ibm) is applying its cognitive computing AI technology to recommend cancer treatment in rural areas in the U.S., India, and China, where there is a dearth of oncologists, said Deborah DiSanzo, general manager for IBM Watson Health.
The drug has an unfortunate side effect of tricking the immune system into attacking healthy cells, but the relative damage was insignificant compared to what cancer would have done to them.
Many laboratory tests were performed and chemotherapy — requiring intravenous punctures — was resumed, even though studies had shown that this type of cancer does not respond significantly, if at all, to drug treatment, and even though complications and side effects from the drugs were expected.
This was before Mackey had won a single Iditarod, let alone four straight; before he used what he calls his marathon style — catnapping as his sled moves and covering 100 - mile chunks at a moderate pace without prolonged rest, instead of sprinting from rest stop to rest stop like most other racers — to win an unprecedented double (the Yukon Quest, the world's other 1,000 - mile dogsled race, and just weeks later the Iditarod) not once but twice; before he became so dominant that slower competitors complained they had no chance to finish within five days of him (the requirement for an official place and a commemorative belt buckle); and before a rival pushed for drug testing at the 2010 Iditarod, suspecting that Mackey's secret was his prescription for medical marijuana to alleviate the side effects of cancer treatment.
Disney said the precise binding of Targapremir - 18a to microRNA - 18a means a cancer drug that follows this strategy would be likely to kill prostate cancer cells without causing the broader side effects seen with many other cancer therapies.
Understanding the biological and genetic basis to drug resistance and cancer progression has enabled researchers to identify and develop a targeted drug that may prove to be beneficial in this type of cancer, without causing unmanageable side - effects.
If researchers could decrease the side - effects of liposome use, doctors could use higher doses of these drugs, perhaps leading to better cancer control.
Beyond the activity of the drugs, the plasmonic effects of the gold nanoparticles could heat the nanoparticles when they are subjected to light, attacking the cancer cells through a second route.
Abiraterone, approved in 2011 for the treatment of metastatic prostate cancer, has a «food effect» that is greater than any other marketed drug.
Other trials of this drug target in lung cancer have not worked, and the drugs» effects in colorectal cancer are also questionable, Stambolic says.
Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.
«Our preclinical data suggest that combining low doses of these inhibitors will enhance the clinical effects of both drugs as a potential treatment for patients with AML,» says the senior author, Feyruz V. Rassool, PhD, associate professor of radiation oncology at the University of Maryland School of Medicine (UM SOM) and a researcher at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC).
«But in mice, it has an unbelievably wide range of effects that you'd never think a single drug could possibly have, ranging from preventing Alzheimer's and cardiovascular disease to reducing cancer.»
This lack of data means that it is difficult to draw a firm conclusion on the effect that fertility drugs in donors may have on cancer risk.
The study also found that the effects of magnesium on pancreatic cancer did not appear to be modified by age, gender, body mass index or non-steroidal anti-inflammatory drug use, but was limited to those taking magnesium supplements either from a multivitamin or individual supplement.
Either way, says Scardino, the study needs to be followed up with others that evaluate the drug's effect in, say, men at higher risk of prostate cancer.
«Since epalrestat is already on the market and has no major adverse side effects, our study provides a proof of principle that it could become a valuable targeted drug for the clinical treatment of basal - like breast cancer,» Dong says.
«Drug used to combat pain medication side effects may help with gastrointestinal recovery: May shorten length of hospital stay following testicular cancer surgery.»
Initially used to protect against side - effects such as fractures, there is also some evidence that taking the drug extends the lives of women with breast cancer.
For example, light - activated switches can fine - tune anti-cancer drugs, so they target only cancer cells and not healthy ones, thereby eliminating the side effects of chemotherapy.
In fact, in this case, two common side effects of the BRAF inhibitor — rashes and a different type of skin cancer — were rare in patients taking the drug cocktail.
Different cancer cells might bear any number of variations that let them escape the drug's effects.
Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.
The study found that combining the two drugs had an increased effect of killing of cancer cells, while individually, the drugs have considerably less impact on cell viability.
The researchers looked at the synergistic effects of the two drugs on packaged DNA inside cancer cells.
«Although the effects of the drug were modest, we now know that we can influence the course of the disease, and we expect to build on this success with other drugs, including some already in development,» said senior author, Gary K. Schwartz, MD, professor of medicine and chief of hematology / oncology at NewYork - Presbyterian / Columbia University Medical Center and associate director of its Herbert Irving Comprehensive Cancer Center.
«Not only does this shed light on how to potentially improve the effectiveness of triple negative cancer treatments, but it also sheds light on the full effect that these common drugs have on our bodies.»
Because some of these neighbour proteins are as central and as global as the cancer - related proteins themselves, and link to so many other processes in the cell, there's a strong likelihood that drugs targeting them may have strong side - effects.
«We first tried a histone methylation inhibitor — a promising new class of cancer drugs — but that did not restore p16 or had any effect on tumor growth.
Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.
This could be a good way to test new types of drugs that target cancer cells specifically and spare patients the side effects from treatments if they are not working.»
The program works by connecting computer - generated drug profiles — including mechanisms of action, clinical efficacy, and side effects — with information about how a molecule may interact with human proteins in specific diseases, such as ovarian cancer.
The common theory is that the cancer cell develops «internal resistance to treatment,» and overrides the toxic effects of the drug.
When hydrochlorothiazide induces cancer, this is because hydrochlorothiazide belongs to a group of drugs with a so - called photosensitising effect.
«After screening a natural compound library, we developed an unbiased look at combinations of nutrients that have a better effect on prostate cancer than existing drugs,» says corresponding author Stefano Tiziani, assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at UT Austin.
But the dogs had no major side effects from taking low doses of the drug, a worry because rapamycin impairs immune system function and could make animals (including people) who take it more vulnerable to infection or cancer.
In the case of the cancer drug L - asparaginase type 2 (L - ASN2), whose primary effect is depleting asparagine, side effects are generally attributed to the corresponding depletion of a chemically similar molecule called glutamine.
Toxic side - effects of a drug used to treat liver cancer could be reduced with a filtration system developed by surgeons in the US.
«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.
And so the challenge is matching drugs with many effects to cancers with many causes in a way that best maps the drugs» effects onto the intended targets,» says Aik Choon Tan, PhD, investigator at the University of Colorado Cancer Center and associate professor of Bioinformatics at the CU School of Medicine.
Professor Sadler comments that this research could lead to new cancer treatments: «Cancer drugs with new mechanisms of actions which can combat resistance and have fewer side - effects are urgently ncancer treatments: «Cancer drugs with new mechanisms of actions which can combat resistance and have fewer side - effects are urgently nCancer drugs with new mechanisms of actions which can combat resistance and have fewer side - effects are urgently needed.
This renders them as sensitive to the effects of the drug as cancer cells, and results in their death.
The Wyss team has unveiled not only a novel design of their «targeted EPO,» but also «targeted interferon alfa,» a cancer drug that can otherwise cause side effects including flu - like symptoms, mood fluctuations, and depression.
«Not only is this new pathway exciting from a discovery perspective, it could ameliorate some of the side effects of cancer and cardiovascular drugs to make them safer and more effective.»
«Since doxorubicin is one of the cheapest drugs that is effective against many types of cancer but rarely used in colon cancer, the combination therapy could be highly effective in combating colon cancer while drastically lowering risk of cardiotoxic side effects.»
«If successful, I envisage it can be a good alternative treatment in the future, one which is low cost and yet effective for the treatment of cancers involving solid tumours, as it might minimise the side effects of drugs.»
The synergistic effect of the two drugs completely eliminated Stat3 expression in pancreatic cancer cells.
Immunosuppressant drugs can have severe side effects, increasing the risk of heart disease, infection, cancer and diabetes.